Old arthritis drug shows promise for Obesity-Related health problems

NCT ID NCT05017571

First seen Sep 30, 2025 · Last updated May 12, 2026 · Updated 34 times

Summary

This study tested whether colchicine, a common anti-inflammatory medicine, could improve metabolism in people with obesity who have high inflammation and high insulin levels but not yet high blood sugar. About 152 adults and teens took colchicine or a placebo daily for 12 weeks. The goal was to see if the drug could lower insulin resistance and inflammation, which are linked to serious health issues like diabetes.

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Contacts and locations

Locations

  • National Institutes of Health Clinical Center

    Bethesda, Maryland, 20892, United States

Conditions

Explore the condition pages connected to this study.