Lack of sleep may trigger diabetes through hormone changes
NCT ID NCT02256865
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study looked at how not getting enough sleep changes hormones like cortisol and testosterone, and whether that leads to insulin resistance—a key step toward type 2 diabetes. Forty healthy men aged 22-45 took part. Researchers used drugs to mimic or block these hormone changes to understand the connection.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Ketoconazole, Hydrocortisone, Testosterone, and placebos
What this could lead to
If successful, this study could help explain why poor sleep increases diabetes risk, pointing toward ways to prevent it.
What could go wrong
This is a very early, small study with only 40 men. It is designed to understand mechanisms, not to test a treatment, so direct health benefits are not expected.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for INSULIN RESISTANCE are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
Los Angeles Biomedical Research Institute
Torrance, California, 90509, United States