Can blocking a nerve signal help insulin work better?

NCT ID NCT03318094

Ongoing Knowledge-focused Sponsor: Vanderbilt University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase study at Vanderbilt University Medical Center is looking at how certain nerve signals (called sympathetic vasoconstriction) might interfere with insulin's ability to widen blood vessels and take up sugar. The researchers will give a drug called phentolamine into the arm to temporarily block those signals, then measure changes in blood flow and insulin sensitivity. The study involves 36 adults aged 18-60 who are obese and have insulin resistance or well-controlled type 2 diabetes.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Phentolamine (alpha-adrenergic blocker)
What this could lead to: If successful, this study could point toward new ways to improve insulin sensitivity in people with obesity and insulin resistance.
What could go wrong: This is a very early, small study (36 people) testing a short-term drug infusion in the arm. It is not designed to prove a treatment works, only to understand the body's response.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEALTHY INSULIN RESISTANCE OBESITY

Contacts and locations

Locations

Autonomic Dysfunction Center

Nashville, Tennessee, 37232, United States

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