Can a tailored diet unlock better metabolic health?
NCT ID NCT04131166
First seen Jul 06, 2026 · Last updated Jul 07, 2026 · Updated 1 time
Summary
This study investigates why some people with obesity develop heart and metabolic problems while others do not, and which diet—Mediterranean, low-carb, or low-fat—best supports metabolic health. Researchers will follow 300 participants, including lean and obese individuals, over several years, measuring insulin sensitivity and glucose levels. The goal is to understand how to personalize dietary recommendations for better long-term health.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Mediterranean diet, low-carbohydrate ketogenic diet, low-fat diet
- What this could lead to
- If successful, this could identify which diet works best for different individuals, paving the way for personalized nutrition plans to improve metabolic health.
- What could go wrong
- This is an observational and behavioral study, not a treatment trial. Results may not apply to everyone, and dietary adherence can vary widely.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Washington University School of Medicine
St Louis, Missouri, 63110, United States
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