Could a fiber supplement boost Metformin's power in obese teens?
NCT ID NCT04578652
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether adding a daily fiber supplement to metformin helps improve insulin resistance and weight loss in teenagers aged 12-18 with severe obesity and a family history of type 2 diabetes. 90 participants will be randomly assigned to receive metformin alone, fiber alone, or both for 12 months. The goal is to see if the combination works better than either treatment alone.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
metformin and a fiber supplement (oligofructose, resistant maltodextrin, acacia gum, PGX)
What this could lead to
If it works, this could point toward a simple, low-cost way to improve insulin sensitivity and reduce weight in adolescents with obesity.
What could go wrong
This is a relatively small, single-center trial. The combination may not be more effective than metformin alone, and the high fiber dose could cause digestive discomfort.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University of Alberta
RECRUITINGEdmonton, Alberta, T6G 2E1, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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