Could a fiber supplement boost Metformin's power in obese teens?

NCT ID NCT04578652

Recruiting now Disease control Sponsor: University of Alberta Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a daily fiber supplement to metformin helps improve insulin resistance and weight loss in teenagers aged 12-18 with severe obesity and a family history of type 2 diabetes. 90 participants will be randomly assigned to receive metformin alone, fiber alone, or both for 12 months. The goal is to see if the combination works better than either treatment alone.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: metformin and a fiber supplement (oligofructose, resistant maltodextrin, acacia gum, PGX)
What this could lead to: If it works, this could point toward a simple, low-cost way to improve insulin sensitivity and reduce weight in adolescents with obesity.
What could go wrong: This is a relatively small, single-center trial. The combination may not be more effective than metformin alone, and the high fiber dose could cause digestive discomfort.

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Conditions

The condition(s) this trial relates to.

Insulin Resistance obesity disorder Pediatric Obesity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INSULIN RESISTANCE OBESITY, CHILDHOOD

Contacts and locations

Locations

University of Alberta
RECRUITING

Edmonton, Alberta, T6G 2E1, Canada

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