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Could mimicking the body's natural insulin pulses improve diabetes testing?

NCT ID NCT06216665

Knowledge-focused Sponsor: Pennington Biomedical Research Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

The body releases insulin in pulses, but the standard test for insulin sensitivity uses a steady drip. This study compares the usual continuous insulin infusion with one given in pulses every five minutes, using the same total amount of insulin. Researchers want to see if the pulse pattern changes the measured insulin sensitivity. The study enrolls a small group of people who have already completed a prior study.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Insulin given either continuously or in pulses every five minutes during a glucose clamp test
What this could lead to
If pulsing insulin changes the measured insulin sensitivity, it could lead to more accurate ways to assess insulin resistance and diabetes risk.
What could go wrong
This is a very small study with only 4 participants, and it measures a lab test, not real-world health outcomes. Results may not apply broadly.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

4 people

The number who actually took part.

Started

Mar 2024

Finished

May 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Completion of the Motivate Study (NCT05649176) Exclusion Criteria: * Non-completion of the end-of-study hyperinsulinemic euglycemic clamp test of the Motivate study

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Conditions

The condition(s) this trial relates to.

Insulin Resistance obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Insulin sensitivity

Contacts and locations

Locations

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana, 70808, United States

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