New drug aims to cool inflammation in heart arteries after attack

NCT ID NCT06927739

Recruiting now Disease control Sponsor: Abcentra Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests a drug called orticumab in 240 people who had a heart attack and still have high inflammation in their heart arteries. Participants receive either orticumab or a placebo for 24 weeks. The main goal is to see if orticumab lowers inflammation measured by a special CT scan. The trial is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

orticumab

What this could lead to

If it works, this could lead to a new treatment that reduces dangerous inflammation in heart arteries after a heart attack, potentially lowering the risk of future heart problems.

What could go wrong

This is an early phase 2 trial with only 240 participants, so results may not apply to everyone. The drug may not reduce inflammation better than placebo, and side effects are still being studied.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

acute coronary syndrome coronary artery disorder coronary atherosclerosis heart disorder Inflammation inflammatory disease myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE CORONARY SYNDROMES ATHEROSCLEROTIC CORONARY VASCULAR DISEASE CORONARY ARTERIAL DISEASE (CAD) HEART DISEASE INFLAMMATION MYOCARDIAL INFARCT

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Abcentra Investigational Site
NOT_YET_RECRUITING

Los Angeles, California, 90048, United States
Abcentra Investigational Site
RECRUITING

Torrance, California, 90502, United States
Abcentra Investigational Site
RECRUITING

Boca Raton, Florida, 33434, United States
Abcentra Investigational Site
RECRUITING

Richmond, Indiana, 47374, United States
Abcentra Investigational Site
NOT_YET_RECRUITING

Louisville, Kentucky, 40202, United States
Abcentra Investigational Site
RECRUITING

Baltimore, Maryland, 21215, United States
Abcentra Investigational Site
RECRUITING

Midland, Michigan, 48670, United States
Abcentra Investigational Site
RECRUITING

Ostrava, Moravian-Silesian Region, 728 80, Czechia
Abcentra Investigational Site
RECRUITING

Pilsen, Plzeň Region, 323 00, Czechia
Abcentra Investigational Site
RECRUITING

Prague, Praha 2, 128 08, Czechia
Abcentra Investigational Site
RECRUITING

Prague, Praha 4, 140 21, Czechia
Abcentra Investigational Site
RECRUITING

Brno, South Moravian, 602 00, Czechia
Abcentra Investigational Site
RECRUITING

Pécs, Baranya, 7635, Hungary
Abcentra Investigational Site
RECRUITING

Budapest, Central Hungary, 1036, Hungary
Abcentra Investigational Site
RECRUITING

Budapest, Central Hungary, 1094, Hungary
Abcentra Investigational Site
RECRUITING

Budapest, Central Hungary, 1132, Hungary
Abcentra Investigational Site
RECRUITING

Nyíregyháza, Szabolcs-Szatmár-Bereg, 4400, Hungary
Abcentra Investigational Site
RECRUITING

Caserta, Campania, 81100, Italy
Abcentra Investigational Site
RECRUITING

Ferrara, Ferrara, 44124, Italy
Abcentra Investigational Site
RECRUITING

Brescia, Lombardy, 25123, Italy
Abcentra Investigational Site
RECRUITING

Milan, Lombardy, 20162, Italy
Abcentra Investigational Site
RECRUITING

Pavia, Lombardy, 27100, Italy
Abcentra Investigational Site
RECRUITING

Krakow, Lesser Poland Voivodeship, 30-082, Poland
Abcentra Investigational Site
RECRUITING

Wroclaw, Lower Silesian Voivodeship, 50-556, Poland
Abcentra Investigational Site
RECRUITING

Warsaw, Masovian Voivodeship, 03-505, Poland
Abcentra Investigational Site
RECRUITING

Baia Mare, Maramureş, 430031, Romania
Abcentra Investigational Site
RECRUITING

Târgu Mureş, Mureș County, 540124, Romania
Abcentra Investigational Site
RECRUITING

Timișoara, Timiș County, 300060, Romania
Abcentra Investigational Site
RECRUITING

Córdoba, Andalusia, 14004, Spain
Abcentra Investigational Site
RECRUITING

Madrid, Madrid, 28034, Spain
Abcentra Investigational Site
RECRUITING

Madrid, Madrid, 28046, Spain
Abcentra Investigational Site
RECRUITING

El Palmar, Murcia, 30120, Spain
Abcentra Investigational Site
RECRUITING

Seville, Sevilla, 41009, Spain
Abcentra Investigational Site
RECRUITING

Danderyd, Stockholm County, 182 88, Sweden
Abcentra Investigational Site
RECRUITING

Solna, Stockholm County, 171 76, Sweden
Abcentra Investigational Site
RECRUITING

Gothenburg, Västra Götaland County, 413 45, Sweden
Abcentra Investigational Site
RECRUITING

London, Greater London, EC1M 6BQ, United Kingdom
Abcentra Investigational Site
RECRUITING

Manchester, Greater Manchester, M23 9LT, United Kingdom
Abcentra Investigational Site
RECRUITING

Oxford, Oxfordshire, OX3 9DU, United Kingdom
Abcentra Investigational Site
RECRUITING

Bath, Somerset, BA1 3NG, United Kingdom
Abcentra Investigational Site
RECRUITING

Sheffield, South Yorkshire, S57AU, United Kingdom