CORONARY ARTERIAL DISEASE (CAD)

This study tests whether a drug-coated balloon can be a safe and effective alternative to stents for treating new blockages in heart arteries. About 1,616 people will be randomly assigned to receive either the balloon or standard stent treatment. The goal is to see if the balloon…

This study tests a new device that uses sound waves to break up calcium deposits in heart arteries before placing a stent. About 408 adults with coronary artery disease will receive this treatment. The goal is to see if the device is safe and effective at clearing blockages to im…

This first-in-human study tests a new device called Pulse IVL that uses sound waves to break up calcium buildup in heart arteries. Up to 15 people with coronary artery disease will receive the treatment before getting a stent. The goal is to see if the device is safe and helps op…

This study tests a new type of heart stent that dissolves over time, unlike permanent metal stents. The trial will enroll 117 people with stable coronary artery disease to see if the new stent, placed with special imaging guidance, works safely and effectively. The goal is to red…

This study looks at whether adjusting the dose of the blood thinner cangrelor based on individual test results can better control clotting in people with coronary artery disease who are waiting for surgery. About 50 adults will receive either a standard or tailored dose to find t…

This study compares two medical devices used to break up hard calcium deposits in heart arteries before placing a stent. It involves 50 adults with coronary artery disease who will be randomly assigned to receive either orbital atherectomy or intravascular lithotripsy. The goal i…

This study tests a new device that freezes dangerous plaque in heart arteries to see if it can reduce blockages and prevent future heart problems. About 30 people with stable angina or recent heart events will receive the freezing treatment during a planned procedure. Researchers…

This study tests two ways to break up heavy calcium buildup in heart arteries before placing a stent: a super high-pressure balloon versus a special shockwave balloon (lithotripsy). About 78 adults with severe coronary artery disease will be randomly assigned to one method. The g…

This study tests whether a reduced dose of the blood thinner prasugrel (5 mg), taken alone without aspirin, is safe and effective for patients who have had a stent placed for heart disease. Researchers will compare this approach to standard dual antiplatelet therapy (aspirin plus…

This study is testing a special balloon coated with the drug sirolimus to treat blocked heart arteries. The balloon is inflated inside the artery to push the blockage aside and release the drug, which helps prevent the artery from narrowing again. Researchers will follow over 1,1…

This study tests whether a genetic score (ABCD-GENE) can help doctors choose the right blood thinner for patients after a heart stent. Currently, patients take two blood thinners for months. The score would guide whether to switch to a milder drug or drop one of the two. The tria…

This study tests a temporary heart pump called the Supira System in 45 people with heart failure and severe coronary artery disease who need high-risk angioplasty. The pump is inserted through a leg artery to help the heart pump blood during and after the procedure. Researchers w…

This study tests a drug called orticumab in 240 people who had a heart attack and still have high inflammation in their heart arteries. Participants receive either orticumab or a placebo for 24 weeks. The main goal is to see if orticumab lowers inflammation measured by a special …

This study looks at 120 people with diabetes who have blocked heart arteries. It compares using a drug-coated balloon together with a drug-eluting stent versus using either device alone. The goal is to see which approach keeps arteries open best after 6 months.

This study tests whether placing stents in non-blocking but unstable heart plaques, along with intensive medication, reduces heart attacks and other cardiac events better than medication alone. About 2,190 adults with acute coronary syndrome will be randomly assigned to either st…

This study looks at whether switching from a standard blood thinner (clopidogrel) to a lower-dose version of another (prasugrel) can better control blood clotting in heart patients who have both high bleeding and high clotting risks after getting a stent. About 40 adults who have…

This study tests whether adding a simple breathing exercise (inspiratory muscle training) to standard cardiac rehab helps people with narrowed heart arteries recover better. 72 adults who had a heart procedure (angioplasty) will be split into two groups: one does standard rehab, …

This study compares a new balloon coated with sirolimus to an existing balloon coated with paclitaxel for treating blocked heart arteries. About 250 adults with coronary artery disease will be randomly assigned to receive one of the two balloons during a procedure to open their a…

This study tests a new, less invasive way to perform coronary artery bypass grafting (CABG) that avoids touching the aorta. The new method uses a small incision in the left chest, while the standard approach opens the chest fully. Researchers will compare how well the bypass graf…

This study tests whether taking spirulina (a microalgae) or seaweed (Gelidium corneum) supplements for 20 weeks can improve markers of heart health and change gut bacteria in people at high risk for heart disease. The trial includes 150 adults aged 50 or older with conditions lik…

This study is testing whether a special heart scan (SPECT) can detect problems in the heart's smallest blood vessels, called microvascular dysfunction. Researchers will measure how the heart muscle moves and pumps blood in 75 people with and without coronary artery disease. The g…

This study tests whether keeping a special chest tube in place for up to 3 days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get the tube p…

This study tests whether applying shockwaves to leg wounds after vein harvesting can reduce healing problems in people undergoing coronary artery bypass surgery. About 120 participants will receive either real shockwave treatment or a sham (fake) treatment. The goal is to see if …

This study tests whether two traditional Chinese medicines—Compound Danshen Dripping Pills and Qishen Yiqi Dripping Pills—can reduce chest pain and improve quality of life in elderly patients (75-90 years old) with coronary heart disease who still have symptoms despite standard t…

This study looks at 1,500 adults with suspected acute coronary syndrome but no clear ST elevation on their ECG. Researchers will test whether an artificial intelligence model can correctly identify those who actually have a blocked artery (occlusion myocardial infarction). They w…

This study reviews the long-term heart health of 1,500 patients who received a drug-eluting balloon to treat coronary artery disease between 2010 and 2025. Researchers will track major heart events like heart attacks, strokes, and repeat procedures. The goal is to better understa…

This study is observing 1,500 people with coronary artery disease to find better ways to predict who is at risk of sudden cardiac arrest. Researchers are looking at genetic, electrical, and biological markers, as well as psychological factors. The goal is to identify high-risk pa…

This study is looking at how well drug-coated balloons work for treating narrowed heart arteries. Researchers will follow 1,500 adults who get this treatment to see how they do in the short and long term. The goal is to gather more information on the success and safety of this ap…