Genetic test could tailor blood thinners after stents, reducing bleeding risk

NCT ID NCT06588595

Recruiting now Disease control Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a genetic score (ABCD-GENE) can help doctors choose the right blood thinner for patients after a heart stent. Currently, patients take two blood thinners for months. The score would guide whether to switch to a milder drug or drop one of the two. The trial involves 90 adults who have had a stent and are on standard dual therapy. Researchers will measure how well the blood is thinned, aiming to find a safer, personalized approach.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Prasugrel, Ticagrelor, Clopidogrel, Aspirin
What this could lead to: If successful, this could show that using a genetic test to choose blood thinners after a heart stent is safer and just as effective as the standard one-size-fits-all approach.
What could go wrong: This is a small, early-phase study (90 people) that only measures blood reactivity, not actual heart attacks or strokes. The genetic score may not work as well in real-world, diverse populations.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERIAL DISEASE (CAD)

Contacts and locations

Locations

University of Florida
RECRUITING

Jacksonville, Florida, 32209, United States

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