CORONARY ARTERIAL DISEASE (CAD)

This study tests whether a lower dose of the blood thinner prasugrel, taken without aspirin, is safe and effective for people who have had a heart stent placed. About 300 adults with acute or chronic coronary artery disease will receive 5 mg of prasugrel daily for 6 to 12 months.…

This study compares two types of drug-coated balloons used to open blocked heart arteries, specifically at branch points (bifurcations). About 250 adults with coronary artery disease will receive either a sirolimus-coated or a paclitaxel-coated balloon. The goal is to see if the …

This study looks at whether adjusting the dose of a blood thinner called cangrelor based on individual test results can better control clotting risk in people with coronary artery disease who are waiting for surgery. About 50 adults will receive either a standard or personalized …

This study tests a special device that uses sound waves to break up hard calcium deposits in heart arteries before placing a stent. About 408 adults with coronary artery disease will receive this treatment. The goal is to see if it is safe and effective at clearing blockages to i…

This study tests whether a super high-pressure balloon or a special shockwave device (intravascular lithotripsy) works better to crack open severely calcified coronary arteries before placing a stent. About 78 adults with hardened heart arteries will be randomly assigned to one o…

This study looks at whether switching from a standard blood thinner (clopidogrel) to a lower dose of another blood thinner (prasugrel) can better control clotting risk in heart patients who have had a stent placed. The study includes 40 adults who are at high risk for both bleedi…

This study tests a new device that uses cold therapy to shrink dangerous plaque in heart arteries. About 30 people with stable angina or recent heart-related chest pain will receive the treatment during a planned procedure. Researchers will use special imaging to check if the pla…

This study tests a drug called orticumab in 240 people who had a heart attack and still have high inflammation in their heart arteries. The goal is to see if orticumab can lower that inflammation better than a placebo over 6 months, using special CT scans to measure changes. Part…

This study compares a drug-coated balloon to standard stent treatment for people with coronary artery disease. About 1,600 participants will be randomly assigned to receive either the balloon or a stent during a procedure to open blocked heart arteries. The goal is to see if the …

This study tests whether keeping a special drainage tube in the chest for up to three days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get…

This study looks at whether using a drug-coated balloon together with a drug-eluting stent works better than using either device alone to open blocked heart arteries in people with diabetes. About 120 participants will be randomly assigned to one of three treatment groups. The go…

This study tests whether taking algae supplements (spirulina or seaweed) for 20 weeks can improve markers of heart health and change gut bacteria in 150 adults aged 50+ with conditions like heart disease, diabetes, or kidney disease. Participants are randomly assigned to receive …

This study is testing a special balloon coated with a drug called sirolimus to treat blocked heart arteries. The balloon is inflated inside the artery to deliver the drug, which helps prevent the artery from narrowing again. About 1,118 adults with coronary artery disease will be…

This study tests whether using a genetic score (ABCD-GENE) to guide reducing blood thinners after heart stent placement works better than the usual approach. About 90 adults who have had a stent and are on two blood thinners will be randomly assigned to either a score-guided or u…

This study tests whether placing stents in non-blocking but vulnerable plaques, along with intensive drug therapy, reduces heart-related events more than drugs alone. About 2,190 adults with acute coronary syndrome will be randomly assigned to one of two groups. The goal is to se…

This study tests a less invasive heart bypass surgery that avoids touching the main artery (aorta) to reduce risks. About 260 people with coronary artery disease will either get this new technique through a small chest incision or standard open-chest bypass. The main goal is to s…

This study compares two methods to treat hardened calcium deposits in heart arteries. About 50 adults with coronary artery disease will be randomly assigned to receive either orbital atherectomy or intravascular lithotripsy during a standard artery-opening procedure. The goal is …

This study tests a new device called the Supira System in 45 people with heart failure and low heart function who need a high-risk heart procedure. The device is designed to help pump blood during and after the procedure, potentially reducing complications. The goal is to see if …

This study looks at whether measuring how well the left side of the heart pumps in sync can help doctors diagnose microvascular dysfunction—a condition where tiny heart blood vessels don't work properly. Researchers will use a special imaging test (SPECT) to check heart timing in…

This study tests whether adding special breathing exercises (inspiratory muscle training) to standard cardiac rehab helps people with heart disease recover better. About 72 adults who had a heart procedure called angioplasty will take part. The goal is to see if this extra traini…

This study tests two traditional Chinese medicines—Compound Danshen Dripping Pill and Qishen Yiqi Dripping Pill—in people aged 75 to 90 with coronary heart disease who still have chest pain or discomfort despite standard treatments. The goal is to see if these herbal remedies can…

This study tests whether applying shockwaves to the leg wound after heart bypass surgery can reduce healing problems like infections. About 120 adults having bypass with vein grafts will be randomly assigned to get either real shockwave treatment or a sham (fake) procedure. The g…

This study looks at the long-term heart health of 1,500 people who had a procedure using a drug-eluting balloon to treat blocked heart arteries. Researchers will review past medical records and then follow participants over time to track serious heart problems like heart attacks …

This study follows 1500 adults with coronary artery disease who receive a drug-coated balloon instead of a stent during a heart procedure. Researchers want to see how well the balloon works in different situations, such as new blockages, narrowed stents, or small vessels. The goa…

This study is observing 1,500 adults with coronary artery disease to identify which factors—like genetics, heart activity, or lifestyle—best predict sudden cardiac arrest or death. Researchers hope to find high-risk patients who could benefit from implantable defibrillators. The …

This study looks at 300 adults with stable coronary artery disease to see if feeling empowered and having a sense of purpose (called 'ikigai') are connected. Researchers will use surveys to measure these factors and how they relate to quality of life. The goal is to help nurses a…

This study looks at 1,500 adults with suspected acute coronary syndrome but no clear ST elevation on their ECG. Researchers will test whether an artificial intelligence model can correctly identify those who actually have a blocked artery (occlusion myocardial infarction). They w…