CORONARY ARTERIAL DISEASE (CAD)

This study is testing whether two types of algae supplements can improve markers of heart health and change gut bacteria in people with conditions like heart disease, diabetes, or kidney disease. 150 participants aged 50+ will take either spirulina, another seaweed supplement, or…

This study is testing a new medical device designed to treat hardened, narrowed heart arteries. The device uses sound wave technology to break up tough calcium deposits in the artery wall before a stent is placed. Researchers aim to see if this approach is safe and effective for …

This study is testing if using a personalized score (the ABCD-GENE score) is better than a standard approach when switching heart patients from a strong blood thinner to a milder one months after getting a stent. It involves 90 patients who have had a stent placed. The goal is to…

This study aims to find a safer medication option for heart stent patients who are at high risk for both blood clots and serious bleeding. It will compare two blood-thinning drugs (clopidogrel vs. a lower dose of prasugrel) in 40 patients who have already had a stent placed. The …

This study is testing a new temporary heart pump device called the Supira System. It aims to see if the pump is safe and can effectively support patients with weak heart function during and after a high-risk procedure to open blocked heart arteries. The device is inserted through…

This study is testing whether using two different artery-opening devices together is better than using just one for people with diabetes and blocked heart arteries. It will involve 120 participants across four hospitals in Ireland. Patients will be randomly assigned to receive ei…

This study is testing whether a special drug-coated balloon can work as well as or better than standard stents for treating newly blocked heart arteries. About 1,600 adults with coronary artery disease will be randomly assigned to receive either the balloon treatment or the usual…

This study is testing if using just one blood-thinning drug at a lower dose is a safe and effective option for patients after a heart stent procedure. It aims to see if this simpler approach can prevent future heart problems while reducing the risk of bleeding, which is a common …

This study compares two less-invasive heart bypass surgery methods for patients with severe coronary artery disease. Researchers want to see if a new 'no-touch' technique, which avoids handling a major artery in the chest, is as safe and effective as a standard minimally invasive…

This study is observing how well a special balloon works to treat blocked heart arteries. The balloon is coated with a medicine called sirolimus, which is meant to help keep the artery open after it's widened. Researchers are following over 1,100 patients with various types of co…

This study aims to find the best way to treat 'vulnerable plaques' in heart arteries that haven't yet caused major blockages. Researchers will compare placing a stent (a tiny mesh tube) plus strong medication against medication alone in 2,190 people who recently had a heart-relat…

This study is testing whether adding special breathing muscle exercises to a standard cardiac rehabilitation program helps people recover better after a heart procedure. Researchers will compare two groups of 72 adults who had a stent placed for heart disease. One group gets the …

This study is testing if a new drug called orticumab can reduce harmful inflammation in the heart arteries of people who have had a heart attack. Researchers will compare the drug's effects against a placebo in 240 participants over 6 months, using special heart scans to measure …

This study compares two different drug-coated balloons used during heart artery procedures. Researchers want to see if a sirolimus-coated balloon works as well as the standard paclitaxel-coated balloon for treating specific branch points in clogged heart arteries. The trial will …

This study is comparing two different tools doctors can use to crack open hardened, calcified plaque in heart arteries before placing a stent. One tool is a super high-pressure balloon, and the other uses sound waves (intravascular lithotripsy). The main goal is to see which meth…

This study is observing how well drug-coated balloons work for treating blocked heart arteries in different situations. It will follow 1,500 patients in Turkey to see if this method, which can sometimes avoid permanent metal stents, is safe and effective in the short and long ter…

This study is testing whether a specialized type of heart scan (called SPECT) can better identify problems with the tiny blood vessels in the heart muscle, a condition known as microvascular dysfunction. Researchers will compare scan results from 75 participants with different ty…

This study is testing whether an artificial intelligence (AI) program can spot a specific type of serious heart attack that doctors often miss on standard tests. It will involve 1,500 patients who come to the hospital with chest pain but don't show the classic signs of a major he…

This study is testing if applying gentle shockwaves to the leg wound after heart bypass surgery can help it heal faster and prevent infections. It will involve 120 patients who are having a specific type of vein harvesting for their bypass. Half will receive the real shockwave tr…

This study is testing whether two traditional Chinese herbal pills, when added to standard heart medications, can better reduce chest pain and improve daily life for elderly patients with coronary artery disease. It will enroll 120 participants aged 75-90 who still have symptoms …

This study aims to find better ways to predict which patients with coronary artery disease are most likely to experience sudden cardiac arrest or death. Researchers will follow 1,500 patients for up to 15 years, collecting data on genetics, heart tests, and lifestyle factors to i…

This study aims to understand the relationship between a patient's sense of empowerment, their quality of life, and their feeling of life purpose (called 'Ikigai') in people with coronary artery disease. Researchers will survey 300 adults with stable heart disease to see how thes…