Fish oil or camelina oil: a simple diet change to fight heart inflammation?

NCT ID NCT07331103

Recruiting now Disease control Sponsor: Mario Negri Institute for Pharmacological Research Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether omega-3 fatty acids from fish oil or camelina oil can reduce inflammation and improve heart health in 324 adults over 55 at moderate to high cardiovascular risk. Participants take daily supplements for 12 weeks, and researchers measure changes in blood markers of inflammation and lipids. The goal is to find a practical dietary way to lower heart disease risk beyond standard treatments.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Fish oil (DHA and EPA), camelina oil (ALA), and vitamin E
What this could lead to: If successful, this could show that simple dietary supplements like fish or camelina oil help control inflammation and lower heart disease risk.
What could go wrong: This is a small, early-stage study (324 people) over only 12 weeks, so results may not apply broadly. The effect on actual heart attacks or strokes is not being measured directly.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder hyperlipidemia Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOVASCUALR DISEASE INFLAMMATION LIPIDS N-3 POLYUNSATURED FATTY ACIDS (N-3 PUFA)

Contacts and locations

Locations

Dr. Antonella Todesca
NOT_YET_RECRUITING

Avellino, AV, 83036, Italy
Dr. Giosafatte Zappia
NOT_YET_RECRUITING

Paderno Dugnano, MI, 20037, Italy
Dr. Tommaso Reginato
RECRUITING

Arese, MI, 20044, Italy
Istituto di Ricerche Farmacologiche Mario Negri
RECRUITING

Milan, MI, 20156, Italy
Ospedale Madonna delle Grazie Matera
NOT_YET_RECRUITING

Matera, MT, 75100, Italy

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