INFLAMMATION

This study is testing whether adding a powdered supplement made from Moringa leaves to standard iron pills can better treat iron deficiency anemia in pregnant women. It involves 59 pregnant women in Indonesia who will take either the standard iron pills alone or the iron pills pl…

This study is testing whether adding high-dose omega-3 fish oil supplements to standard antidepressant medication can help people with depression that hasn't fully responded to treatment. Researchers want to see if the supplements reduce body inflammation and if that reduction is…

This large, late-stage study is testing whether a new monthly injection called ziltivekimab can reduce the risk of major heart problems like heart attacks and strokes. It involves about 6,200 people who already have heart disease, chronic kidney disease, and signs of body-wide in…

This study is testing whether eating 1.5 cups of fresh mango every day for 12 weeks can help improve health markers in adults with prediabetes. Researchers are measuring changes in blood sugar, cholesterol, inflammation, and body composition. Participants will eat mango daily for…

This study is testing whether colchicine, an anti-inflammatory medication, can slow the progression of aortic valve stenosis—a serious heart condition where the main heart valve narrows. Researchers are enrolling 150 patients with moderate but symptom-free valve narrowing to see …

This study is testing whether a one-year course of a dietary supplement called spermidine can help older adults with heart disease. Spermidine is a natural compound found in foods like whole grains and nuts. Researchers will check if it improves heart function, muscle mass, physi…

This study is testing whether eating a specific high-fiber, plant-based Mediterranean diet for two weeks after a colonoscopy can improve gut health. Researchers will enroll 30 people with a history of colon polyps to see if the diet reduces inflammation, changes gut bacteria, and…

This study is testing whether switching to a plant-based diet can improve heart health and reduce inflammation in people who have received a kidney transplant. Researchers are helping 25 participants follow the diet for at least 16 weeks, with training and support. They will meas…

This study is testing whether switching to a whole-food, plant-based diet can help lower markers linked to cancer risk in firefighters. For 12 weeks, 120 active San Francisco firefighters will either follow this special diet or eat their usual meals. Researchers will measure chan…

This study is testing a comprehensive prevention program for long-term smokers aged 55-75. The program combines low-dose aspirin, a quit-smoking medication, a Mediterranean-style diet, and increased physical activity, along with annual lung scans. The goal is to see if this multi…

This study is testing if a monthly injection that lowers inflammation can help older adults walk faster, feel less tired, and think more clearly. About 60 adults aged 70 and older with mild mobility issues and higher inflammation levels will receive either the real drug or a plac…

This study aims to understand why whole wheat bread helps lower blood sugar for some people with prediabetes but not others. Researchers are comparing the effects of eating whole wheat bread versus white bread for two weeks at a time in 65 adults with prediabetes. They will colle…

This study aims to understand if hormone levels and signs of inflammation in the blood are linked to how severe Parkinson's disease is. Researchers will enroll 300 people with Parkinson's to measure their hormone levels and check blood markers. The goal is to find simple, non-inv…

This study aims to understand if a common oral typhoid vaccine causes temporary changes in the gut's protective barrier. Researchers will measure gut permeability and immune responses in 10 healthy volunteers before and after they receive the vaccine. The goal is to gather basic …

This study aims to understand how common heart disease and its risk factors are among adults in Port-au-Prince, Haiti. Researchers will follow about 3,000 people for several years, tracking their health, lifestyle, and diet. The goal is to gather information to help plan better h…

This small, withdrawn pilot study aimed to understand if taking fish oil supplements while doing high-intensity exercise could work together to reduce harmful inflammation linked to obesity. Researchers wanted to see if fish oil improved gut bacteria, which might make exercise mo…

This study aims to understand how eating more fiber-rich foods, fermented foods, or both during pregnancy affects the mix of bacteria in a mother's gut and how that gets passed to her baby. Researchers will follow 135 healthy pregnant women and their infants for several years, co…

This study aims to understand how patients from different countries and backgrounds differ when they receive a TAVI procedure for a narrowed heart valve. Researchers will look back at the medical records and CT scans of 800 patients to compare their heart anatomy, blood test resu…

This study aimed to understand if a specific type of immune cell (T cells) causes arteries to stiffen and function poorly as people age. Researchers planned to test this by giving an existing arthritis drug, Abatacept, to healthy older adults to see if it improved artery health. …

This study aims to observe and follow people with various inflammatory conditions over time, not to test a new treatment. It will create a group of patients who might be eligible for future research studies and help train doctors. Participants will receive standard medical evalua…

This study aims to understand how nutritional counseling and combined exercise training affect markers of cellular aging in older women. It will involve 80 women aged 60-75, comparing those with normal weight and obesity. Researchers will measure changes in cell health, inflammat…

This study aims to understand how different amounts of pre-season friendly match play affect soccer players' bodies. Researchers will measure 24 male players' fitness, blood markers for muscle damage and inflammation, and performance at three points during pre-season. Players wil…

This project is not a new treatment trial, but a large-scale analysis of past research. Researchers are compiling and reviewing results from many existing diet studies to understand if replacing animal protein (like meat and dairy) with plant protein (like beans and nuts) leads t…

This study aims to understand how often and why patients experience memory and thinking problems after hip or knee replacement surgery. Researchers are following 505 patients aged 50+ to track their cognitive function before and after surgery for several months. The goal is to id…

This study is testing whether giving extra amino acids (the building blocks of protein) through an IV can help critically ill patients in the ICU shift their bodies from breaking down muscle to building it up. Researchers will measure protein balance and look for molecular signal…

This study aims to better understand how a group of rare genetic disorders, called mucopolysaccharidoses (MPS), affects heart and blood vessel health over time. Researchers will follow 30 patients for three years, using annual heart ultrasounds, neck artery scans, and blood tests…

This study aims to find a simpler way to identify people whose blood pressure is sensitive to salt. Researchers will test 20 adults with high blood pressure by carefully changing their salt levels in a hospital and measuring their blood pressure and immune cell responses. The goa…