Triple-Pronged attack on lung cancer: aspirin, smoking cessation, and lifestyle changes tested in new trial
NCT ID NCT03654105
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a combination of low-dose aspirin, a smoking cessation drug called cytisine, and guidance on diet and exercise can reduce chronic inflammation and lower lung cancer risk in heavy smokers aged 55 to 75. The 2000 participants will also receive annual low-dose CT scans for early detection. The goal is to see if this multi-pronged approach can lower inflammation levels and help people quit smoking.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- low-dose aspirin (acetylsalicylic acid) and cytisine (a smoking cessation aid)
- What this could lead to
- If it works, this could point toward a practical combination of lifestyle changes and medication to lower lung cancer risk in long-term smokers.
- What could go wrong
- This is a mid-stage pilot study with 2000 participants, so results are not definitive. The benefits may be small, and aspirin can cause bleeding or stomach issues.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133, Italy
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