INFLAMMATION

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study looked at whether a 24-week exercise program can improve physical fitness, muscle strength, and overall health in people who received a kidney transplant. 345 adults joined the study six months after their transplant. Researchers compared those who exercised with those…

This completed trial tested whether sleeping near a device that emits biophotons (tiny light particles) could increase the number of stem cells people naturally produce. 71 healthy adults aged 18-70 took part, with some using real devices and others using placebo devices. The stu…

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Par…

This study tested an experimental drug, ziltivekimab, in 36 adults with advanced chronic kidney disease (not on dialysis) to see if it can safely reduce inflammation and related heart risks. Participants received either a low dose, a high dose, or a placebo injection every 4 week…

This pilot study tested whether colchicine, an anti-inflammatory drug, can slow the buildup of calcium in the aortic valve. 24 adults with mild-to-moderate aortic stenosis were randomly assigned to take colchicine or a placebo for 6 months. The study measured changes in valve cal…

This study tested whether colchicine, a drug used for gout, can reduce inflammation in the arteries of people with diabetes who recently had a heart attack or stroke. Researchers used a special PET scan to measure inflammation in the blood vessels. 115 participants were randomly …

This study tested whether a daily freeze-dried micro-vegetable blend can reduce inflammation in adults aged 60 and older with a BMI over 25. Thirty-two participants took the supplement or a placebo for six weeks. Researchers measured changes in proteins and inflammatory markers i…

This study looked at whether eating a whole-food, plant-based diet for 8 weeks could lower markers of cancer and inflammation in firefighters. 121 active firefighters participated. Researchers measured changes in blood markers like IL-6 and C-reactive protein to see if the diet m…

This completed trial tested whether a mix of 43 plant polyphenols can counteract health damage from environmental pollutants. 98 adults took either the polyphenol supplement or a placebo for a period. Researchers measured changes in gut health, inflammation, and blood markers to …

This study tested whether taking a daily Cistanche deserticola supplement along with moderate aerobic exercise (40 minutes, 3 times a week for 18 weeks) could improve body composition, insulin resistance, and inflammation in men aged 50-55 with central obesity. 125 men were rando…

This study looked at whether garlic supplements can improve blood vessel function and reduce inflammation in adults with kidney failure who are on hemodialysis. Fifty-eight patients took garlic extract or a placebo for a period of time. Researchers measured markers of inflammatio…

This study looked at whether tiny plastic particles (microplastics) we encounter daily might contribute to obesity and gut problems. Researchers gave 96 overweight or obese adults either a probiotic supplement or a placebo to see if the probiotic could reduce the harmful effects …

This study tested whether a fermented milk drink containing Lactobacillus casei strain Shirota (sold as Yakult) could improve gut health and slow muscle loss in 132 elderly Taiwanese adults with sarcopenia. Participants drank two bottles daily for 12 weeks. Researchers measured c…

This study tested a device called HA-380® that filters inflammatory substances from the blood during heart-lung bypass in complex cardiac surgeries. Forty-one adults undergoing high-risk procedures like heart transplants or aortic dissection repairs were enrolled. The goal was to…

This study looked at whether eating more dairy products for 6 weeks could lower inflammation and other signs of heart disease in overweight adults. Thirty-two people with low dairy intake and at least two other risk factors (like high blood pressure or blood sugar) took part. Res…

This study looked at whether taking probiotics alongside regular diabetes medications can improve blood sugar, cholesterol, and inflammation in adults with type 2 diabetes. Researchers enrolled 77 people aged 35-65. The goal was to see if changing gut bacteria with probiotics cou…

This study tested whether a daily supplement made from a mushroom extract (PsP) could reduce markers of oxidative stress and inflammation in 200 adults who smoke or are exposed to smoke. Participants took either PsP or a placebo for 8 weeks, and researchers measured changes in bl…

This study tested a drug called ziltivekimab in 264 people with advanced chronic kidney disease and high inflammation. Participants received monthly injections of either a placebo or one of three doses of ziltivekimab for six months. The goal was to see if the drug could safely l…

This study tested whether taking green tea extract for one month could improve gut health and reduce inflammation in people with metabolic syndrome and in healthy adults. Participants took either the extract or a placebo for a month, then switched. The study measured markers of i…

This study tested a protein called GcMAF, which is made from vitamin D-binding protein and is thought to calm the immune system. Researchers gave it to 120 adults with chronic inflammatory conditions like rheumatoid arthritis or cystitis that didn't improve with standard treatmen…

This study looked at whether taking fish oil and doing high-intensity interval training (HIIT) could lower inflammation in people who are overweight or obese. Researchers measured changes in blood markers of inflammation and metabolism over 10 weeks. The goal was to see if the co…

This completed Phase 2 trial tested whether colchicine, an anti-inflammatory drug, can improve insulin resistance in 152 adults and adolescents with obesity. Participants took either colchicine or a placebo daily for 12 weeks. The study measured changes in insulin resistance and …

This study tested a single injection of dexamethasone (Dexycu) given during cataract surgery to control eye inflammation. Researchers compared 263 patients who received the injection to an external control group. The main goal was to see how many patients had no signs of inflamma…

This study tested whether a quick fingerstick blood test for D-Dimer (clot marker) and CRP (inflammation marker) gives the same results as standard lab tests using blood from a vein. Researchers enrolled 111 adults and compared results from fingerstick, venous whole blood, and pl…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a new, low-cost tool called the Intensive Care Infection Score (ICIS) to see if it can better detect bacterial infections in burn patients compared to standard blood tests. Researchers studied 97 adults and children hospitalized for burns. The goal was to improv…

This study looked at two simple tests—a breath test (FeNO) and a blood test (eosinophil count)—to see if they can diagnose asthma more easily than current hospital-based breathing tests. Researchers studied 123 people aged 12 and older with suspected asthma. The goal was to find …

This study tested whether clazakizumab, an anti-inflammatory drug, could improve walking speed and reduce disability in older adults with frailty. 29 participants aged 70 and older received either the drug or a placebo every 4 weeks for 24 weeks. Researchers measured walking spee…

This study tested a Dialectical Behavior Therapy skills training program for older adults (age 50+) who care for a family member with Alzheimer's disease or related dementias. The goal was to reduce suicidal thoughts and feelings. Nine caregivers participated, and the program foc…

This pilot study tested whether taking a green tea extract (EGCG) plus vitamin C daily for 12 weeks is safe and feasible for older cancer survivors who are frail or pre-frail. The study enrolled 24 people aged 65 and older who had completed cancer treatment. The main goal was to …

This study tested avenanthramide, a natural compound found in oats, to see if it is safe and how the body processes it. Researchers gave single and multiple doses to 92 healthy volunteers and people with low-grade inflammation. The goal was to check for side effects and measure l…

This study tested whether a single 60-minute session of relaxing music (60-80 bpm) played through headphones could reduce stress and inflammation in 110 sedated adults on breathing machines in the ICU. Researchers measured stress hormones and inflammatory markers in blood before …

This study tested whether a probiotic called Lactobacillus rhamnosus GG can reduce inflammation and PTSD symptoms in veterans. Researchers enrolled 383 veterans with PTSD and gut issues, giving them either the probiotic or a placebo. The goal was to see if calming inflammation in…

This study tested whether applying cold packs to the thighs can reduce muscle pain, swelling, and inflammation after exercise. 48 healthy adults aged 18–30 performed a workout to cause muscle soreness, then used the Axanova Cold Hot Pearls Maxi Pack for 20 minutes three times a d…

This study tested whether applying cold therapy (cryotherapy) inside the mouth or inside the tooth itself can reduce pain and inflammation after root canal treatment. Thirty adults with painful tooth infections received either an oral cold pack, a cold saline rinse inside the too…

This completed study tested whether daily blueberry powder can improve immune function in overweight men and postmenopausal women aged 50-70. Participants took either blueberry powder or a placebo for a period, and researchers measured changes in immune cells and inflammation. Th…

This study tested a special sleep program for 40 people who recently lost their spouse or long-term partner. The program used online sessions to teach better sleep habits and was compared to just giving information. The goal was to see if it could improve sleep and reduce inflamm…

This study looked at whether taking powdered tart cherries for 10 days helps trained adults recover faster after repeated sprints. Forty healthy men and women took either tart cherry powder or a placebo, then did a series of 30-meter sprints. Researchers measured muscle soreness,…

This study tested whether taking UC-II, glucosamine, and curcumin together can reduce knee pain and inflammation. Thirty-two adults with chronic knee pain were randomly assigned to receive the supplement or a placebo for a set period. Researchers measured pain levels, knee functi…

This study tested whether a 12-week training program (called the Integrated Stress Toolbox) could help healthcare workers in Mexico feel less stressed and burned out. Over 2,300 participants were randomly assigned to either the training or a waitlist. The training included an app…

This study tested whether a daily supplement called ETAS®, made from asparagus, could improve memory, mood, and reduce inflammation in healthy adults aged 60-80 who had mild memory concerns. 45 participants took either a low or high dose of ETAS® or a placebo for 12 weeks. Resear…

This study tested whether using an ultrasonic surgical device (piezosurgery) instead of standard rotary tools reduces pain, swelling, and jaw stiffness after removing impacted wisdom teeth. Twenty-two healthy adults each had one tooth removed with the ultrasonic device and the ot…

This study tested whether taking Montmorency cherry supplements could improve sleep and reduce inflammation in adults with sleep problems and higher body weight. Thirty-four participants took either the cherry supplement or a placebo for a period of time. Researchers measured sle…

This completed study looked at how inflammation might connect heart disease and diabetes. Researchers used PET scans and blood tests to measure inflammation in 150 adults, including healthy volunteers. The goal was to better understand these links, not to test a new treatment.

This completed study looked at 386 adults with psoriasis to understand how skin inflammation might be linked to heart and blood vessel diseases. Participants had up to seven visits over four years, including blood tests, heart scans, and optional skin biopsies. The goal was to se…

This study looked at 40 children with congenital heart disease who had heart surgery. During surgery, doctors used a special filtering technique called SBUF-SMUF to remove inflammatory substances from the blood. The goal was to see how this affected inflammation and recovery. The…

This study looked at markers of inflammation, blood clotting, and blood vessel function in 310 HIV-infected adults and healthy volunteers. Researchers collected blood samples to understand how these markers relate to HIV and risks like heart disease or stroke. The goal was to gat…

This study looked at how eating a high-fat diet for 5 days affects inflammation in older adults (ages 50-79) with normal weight or obesity. Researchers measured blood markers and gut bacteria to see if a high-fat diet causes more inflammation than a low-fat diet. The goal was to …

This observational study looked at how legal cannabis use changes alcohol drinking habits, gut bacteria, and brain function in people who regularly use both alcohol and cannabis. 77 heavy drinkers who also smoke cannabis took part, providing blood and stool samples and completing…

This completed study looked at 115 people with inflammatory bowel disease (IBD) to see if their condition raises the risk of atherosclerosis, a hardening of the arteries that can lead to heart attacks and strokes. Researchers measured artery stiffness and thickness, and tracked h…

This study looked at how acute inflammation changes blood flow in the skin and affects mood. Twenty-five healthy adults received either a placebo or an inflammation-triggering injection on separate days. Researchers measured skin temperature, blood flow, and psychological respons…

This study looked at how different levels of processing in plant-based protein foods change the bacteria in your gut and your body's chemistry. 38 healthy adults ate these foods so researchers could measure changes in metabolism, gene activity, and inflammation. The goal was to u…

This study looked at whether people who used a tobacco heating system for at least 2 years had lower levels of harmful chemicals, cell stress, and inflammation in their bodies compared to cigarette smokers. About 974 healthy adults aged 30-60 from Asia and Europe took part. The g…

This study looked at 140 intensive care unit (ICU) healthcare workers to see if burnout and stress are linked to changes in their blood. Researchers measured stress levels using questionnaires and checked for signs of inflammation in blood samples. The goal was to understand how …

This study looked at how certain genes in blood cells respond to environmental exposures in 178 healthy volunteers aged 18 to 45. Researchers measured gene activity to better understand links to inflammation, cancer, and other diseases. The goal was to gather knowledge, not to pr…

This completed study examined how diet influences inflammation and metabolism in 393 healthy and obese adults. Researchers measured immune cells, hormones, and other markers after participants ate a high-fat meal. The goal was to better understand the complex interactions between…

This study tested whether a daily NAD+ supplement can improve thinking and reduce inflammation in healthy women aged 40 to 80. Participants took either NAD+ or a placebo for 4 weeks and completed computer tests and blood draws. The goal was to see if NAD+ affects memory, attentio…

This study looked back at 266 hospitalized adults who had a special type of PET scan (FDG-PET/CT) to find the cause of an unexplained fever or inflammation. The goal was to see how often the scan helped doctors make a diagnosis and whether it changed patient care. Results will he…

This study looked at 100 overweight veterans to see if losing weight and doing aerobic exercise could lower inflammation linked to aging. Researchers measured inflammatory chemicals from fat tissue and checked fitness, body composition, and blood sugar. The goal was to understand…

This study looked at how three different types of dietary fats affect inflammation, blood fats, blood sugar, and gut bacteria in 25 healthy adults aged 18-60. Participants ate special diets to see which fat source caused the least inflammation and best heart health markers. The g…

This study looked at 130 people with lumbar disc herniation (a slipped disc in the lower back) to see if a blood-based immune-inflammatory index could predict whether the disc would shrink without surgery. Researchers compared patients who had surgery to those who received only m…

This study looked at whether donating plasma more often affects protein levels, inflammation, and mental health in male blood donors. 120 men were split into three groups: one donated plasma three times every two weeks, another every two weeks, and a third donated whole blood eve…

This small study looked at whether dairy products like skim milk and Greek yogurt, taken right after intense exercise, affect bone turnover and inflammation in healthy young adults. Twenty participants did high-intensity exercise and then consumed either dairy, a carbohydrate dri…

This study tested a plant-based supplement called LLP-01 in 32 healthy adults aged 50 to 75. Researchers measured changes in blood markers related to inflammation and heart health, as well as grip strength and well-being. The goal was to see if the supplement could improve these …

This study followed 196 people with advanced lung or stomach cancer who had not yet received treatment. Researchers wanted to see if emotional distress before starting immunotherapy, along with certain blood markers of inflammation and metabolism, could predict how long patients …

This small study looked at how a class of diabetes drugs called SGLT2 inhibitors might reduce inflammation linked to heart and kidney disease. Six healthy adults took the medication for three days, and researchers measured changes in blood markers of inflammation. The goal was to…

This study looked at whether avoiding plastic in food, personal care, and cleaning products can lower levels of plastic-related chemicals in the body and improve health markers in adults with heart disease risk factors. Sixty participants either followed a low-plastic lifestyle f…

This study looked at whether adding a fiber supplement (inulin) to a low-fiber diet could increase helpful gut bacteria and improve the immune response to a typhoid vaccine. Sixty healthy adults with low fiber intake took either inulin or a placebo for five weeks, and all receive…

This study looked at how full-fat and fat-free milk and yogurt affect the gut microbiome and heart disease risk factors. 37 adults over 50 drank specially prepared dairy drinks for a period. Researchers measured changes in gut bacteria, metabolic byproducts, and blood markers to …

This study looked at whether a score called Modified EASIX, calculated from routine blood tests, can help predict how severe erectile dysfunction (ED) is. Researchers reviewed medical records of 380 men aged 18-65 and compared the score between those with and without ED. No treat…

This study looked at whether gum disease (periodontitis) and Parkinson's disease are connected through inflammation. Researchers collected saliva and blood samples from 60 people—some with both conditions, some with only gum disease, and some healthy. They found that certain subs…

This study tested a new experimental drug called MMV367 in 12 healthy adults. Participants were intentionally infected with a controlled, low-level malaria infection to see how well the drug works and how safe it is. The goal was to measure how the body processes the drug and how…

This completed study tested whether a daily fermented soy powder (Q CAN PLUS) could improve thinking skills, immune function, and response to the flu shot in healthy adults aged 65 and older. 62 participants took either the soy supplement or a placebo for 16 weeks. Researchers me…

This study looked at how inflammation affects feelings of pleasure and motivation in older adults (ages 60-80) with anxiety. Researchers used brain scans and computer tasks to measure reward responses. The goal was to better understand the link between anxiety, inflammation, and …

This study tested whether eating almonds every day can improve the immune system's response to the flu vaccine in overweight middle-aged men and postmenopausal women. Participants either added almonds as a snack or avoided them for several weeks. Researchers measured immune cell …

This study looked at whether a blood marker called PTX3 can predict how well people do after gastric bypass surgery. Researchers followed 23 patients for 6 months after surgery, measuring weight loss, insulin resistance, and inflammation. The goal was to see if PTX3 levels before…

This study looked at 155 adults who had weight-loss surgery to see if using a low-flow or standard-flow anesthesia gas changed inflammation levels in the body. Researchers measured blood markers like CRP before and after surgery. The goal was to learn more about how anesthesia af…

This study looked at how CrossFit and traditional resistance training affect inflammation and oxidative stress in people who don't usually exercise. Twenty-four healthy, untrained adults followed a 12-week program with five sessions per week. Researchers measured blood markers be…

This observational study followed 300 people with hand osteoarthritis for up to 8 years. Researchers used imaging (X-rays, CT, MRI, ultrasound), physical exams, and questionnaires to track pain, inflammation, and joint changes. The goal was to better understand how the disease pr…

This study looked at how nutrition, meal patterns, and diet affect quality of life, gut symptoms, and mood in 50 people with inflammatory bowel disease (IBD). Researchers collected data using food recalls and questionnaires. The goal was to better understand the role of diet in m…

This study looked at 30 young Polish rowers to understand how their bodies handle intense exercise. Researchers measured hormones, metabolism, and iron levels before and after a 2000-meter rowing test. The goal is to learn more about how athletes adapt to physical strain, not to …

This study looked at whether taking a daily PQQ supplement for six weeks can improve how non-endurance athletes burn fat and use energy during exercise. Twenty-four basketball players were randomly assigned to receive either PQQ or a placebo. Researchers measured fat oxidation, b…

This study looked at whether eating more Greek yogurt for 8 weeks could improve bone health and lower inflammation in adults aged 55 and older. Forty participants either ate yogurt with or without exercise, or just exercised without yogurt. Researchers measured blood markers of b…