Could an antibody fight both psoriasis and heart disease?

NCT ID NCT04776629

Completed Disease control Sponsor: Abcentra Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Participants received either the drug or a placebo, and researchers measured changes in psoriasis severity and other health markers.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: orticumab (a lab-made antibody targeting oxidized LDL)
What this could lead to: If it works, this could point toward a treatment that helps both psoriasis skin symptoms and related heart disease risks.
What could go wrong: This is a small, early-phase proof-of-activity study, not a large confirmatory trial. The drug may not improve psoriasis or heart markers, and side effects are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome coronary artery disorder Inflammation inflammatory disease metabolic syndrome X psoriasis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARDIOMETABOLIC SYNDROME CORONARY ARTERY DISEASE INFLAMMATION PSORIASIS

Contacts and locations

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Locations

Blue Coast Research Center

Vista, California, 92083, United States
CCT Research - Springville Dermatology

Springville, Utah, 84663, United States
CCT- Research at the center for Dermatology and Plastic Surgery

Scottsdale, Arizona, 85260, United States
Center for Clinical Studies, LTD.LLP

Webster, Texas, 77598, United States
Dawes Fretzin Clinical Research Group, LLC

Indianapolis, Indiana, 46250, United States
Derm Institute & Skin Care Ctr., Inc.

Santa Monica, California, 90404, United States
Excel Clinical Research

Las Vegas, Nevada, 89109, United States
Jacksonville Center for Clinical Research

Jacksonville, Florida, 32216, United States
Las Vegas Clinical Trials

Las Vegas, Nevada, 89030, United States
Orange County Research Center

Tustin, California, 92780, United States
SMS Clinical Research

Mesquite, Texas, 75149, United States
Texas Dermatology and Laser Specialists

San Antonio, Texas, 78218, United States
Vital Prospects Clinical Research Institute, PC

Tulsa, Oklahoma, 85260, United States

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