Could a fiber supplement boost your vaccine?
NCT ID NCT04543877
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at whether adding a fiber supplement (inulin) to a low-fiber diet could increase helpful gut bacteria and improve the immune response to a typhoid vaccine. Sixty healthy adults with low fiber intake took either inulin or a placebo for five weeks, and all received the typhoid vaccine. Researchers measured changes in gut bacteria, inflammation, and vaccine antibody levels.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Inulin (a type of dietary fiber)
What this could lead to
If it works, this could point toward simple dietary changes to improve vaccine effectiveness and gut health.
What could go wrong
This is a very early, small study (60 people) looking at lab markers, not actual disease outcomes. Results may not apply to other vaccines or populations.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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USDA, ARS, Western Human Nutrition Research Center
Davis, California, 95616, United States