Plasma donation study: frequent Donors' health under the microscope

NCT ID NCT05179200

Completed Knowledge-focused Sponsor: Sykehuset Innlandet HF Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looked at whether donating plasma more often affects protein levels, inflammation, and mental health in male blood donors. 120 men were split into three groups: one donated plasma three times every two weeks, another every two weeks, and a third donated whole blood every three months. Researchers measured blood proteins and psychological distress before, during, and after the 16-week donation period to see if frequent donation is safe.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this study could help set safer guidelines for how often people can donate plasma without harming their health.
What could go wrong: This is a small, completed study in healthy male donors only, so results may not apply to women or people with health conditions. It does not test a new treatment.

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Conditions

The condition(s) this trial relates to.

Inflammation inflammatory disease Protein Deficiency protein S deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFLAMMATION PROTEIN DEFICIENCY PSYCHOLOGICAL DISTRESS

Contacts and locations

Locations

Innlandet Hospital Trust

Lillehammer, 2609, Norway

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