Salt shield? study tests ketone supplement to lower blood pressure risks in seniors

NCT ID NCT06868719

Recruiting now Disease control Sponsor: Indiana University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

Most older Americans eat too much salt, which can raise blood pressure and harm the kidneys. This study tests whether a ketone supplement (a substance the body makes during fasting or exercise) can block those harmful effects. Thirty-five adults aged 60-85 will follow a high-salt diet for 10 days, with or without the supplement, to see if it keeps blood pressure and blood vessel function healthy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketone supplement (beta-hydroxybutyrate)
What this could lead to: If it works, this could point toward a simple supplement to help older adults counteract the negative effects of a high-salt diet without needing to drastically change what they eat.
What could go wrong: This is a very small, short-term pilot study (35 people, 10 days). It is not designed to prove long-term benefits or safety, and results may not apply to everyone. The supplement may not work as well in humans as it did in rodents.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder hypertensive disorder Inflammation inflammatory disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGING BLOOD PRESSURE HYPERTENSION INFLAMMATION SALT; EXCESS

Contacts and locations

Locations

School of Public Health
RECRUITING

Bloomington, Indiana, 47405, United States

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