DEPRESSION, ANXIETY

This trial tests whether a structured family support program helps relatives of critically ill patients in intensive care units (ICUs). The program includes a specialist nurse who supports families from admission through discharge and follow-up, plus better communication between …

This study tested a program that combines small loans and group support to help people with HIV in Kenya. The goal was to improve HIV medication adherence, mental health, and family relationships. 843 people took part, and the program aimed to reduce depression, anxiety, and PTSD…

This study tested a mobile program called Comunică to help Romanian gay and bisexual men reduce HIV risk and heavy drinking. 300 participants used their phones or laptops to complete surveys and eight one-hour sessions with a counselor or by reading health information. The progra…

This study compared two psychological treatments—cognitive behavioral therapy (CBT) and Ericksonian hypnosis—for reducing symptoms of depression and anxiety. 45 adults with symptoms but no formal diagnosis were randomly assigned to CBT, hypnosis, or a no-treatment control group. …

This study tested an online guided self-help program called EMPOWER for medical professionals with mild depression or anxiety. The program teaches problem-solving and acceptance skills through videos and stories. 161 participants were randomly assigned to the program or a control…

This study tested whether an AI chatbot called Emohaa can reduce symptoms of depression, anxiety, and loneliness in young adults aged 15 to 30. 222 participants with emotional distress were randomly assigned to use the chatbot, receive traditional counseling, or join a waitlist. …

This study looked at whether online laughter therapy could help people on hemodialysis feel less depressed, anxious, and stressed, and improve their quality of life. Sixty-nine adults who were on dialysis took part. They did laughter therapy sessions online. The results showed th…

This study tested a problem-solving therapy program for family caregivers of people with cancer who were receiving palliative care. Over 500 caregivers took part to see if the therapy could reduce their anxiety and depression. The goal was to improve caregivers' emotional well-be…

This study tested a digital program to support the mental health of doctors during the COVID-19 pandemic. 293 physicians from Penn Medicine took part. The program included text messages, resource support, and peer groups. Researchers measured changes in well-being, depression, an…

This study tested whether a program called PRISM (Promoting Resilience in Stress Management) could help young adults aged 18-39 who have cancer or desmoid tumors manage anxiety and depression. The program teaches skills like stress management, goal setting, and positive thinking.…

This study tested a new, non-invasive treatment for major depression called transcranial photobiomodulation (tPBM), which uses near-infrared light on the scalp. Fifty adults with depression received either real light therapy or a sham treatment three times a week for six weeks. T…

This study tested a new online program for people with gut-brain interaction disorders (DGBI) who also have anxiety or depression. 27 adults tried self-guided online sessions and gave feedback through interviews and questionnaires. The goal was to see if the program is easy to us…

This study tested a simple web-based platform called Adhere.ly to help therapists and their clients with therapy homework. 79 adults with anxiety or depression took part. The goal was to see if using the tool improved symptoms and quality of life compared to standard therapy alon…

This study tested whether a single dose of ketamine, given during spinal surgery, can reduce depressive symptoms afterward. 110 adults with moderate to severe depression received either ketamine or a saltwater placebo. The goal was to see if ketamine could lower depression scores…

This study tested a new cognitive behavioral skills program (CBI) delivered in the metaverse for people with depression and anxiety. 306 participants were split into three groups: one using virtual reality, one using a flat-screen device, and a waitlist group. The program taught …

This study tested whether a single low dose of esketamine, given during anesthesia, could reduce anxiety and depression in 142 adults undergoing heart valve surgery. Participants were randomly assigned to receive either esketamine or a placebo (saline). The researchers measured m…

This study tested whether a mobile app called IntelliCare can reduce depression and anxiety in breast cancer survivors. 313 women who had been diagnosed within the past 5 years and had elevated symptoms used the app or received standard educational materials. The study also looke…

This study tested whether using virtual reality (VR) exposure therapy could prevent anxiety, depression, and PTSD in people recovering from a lung transplant in the ICU. 62 adults on the lung transplant waiting list participated. They used a VR headset to gradually get used to st…

This study tested two online programs—cognitive behavioral therapy (CBT) and mindfulness—to help adults cope with the distress caused by tinnitus (ringing in the ears). 67 participants were randomly assigned to one of the two treatments or a waiting list. The goal was to see if t…

This study tested a 16-week parenting program called KEEP for foster and kinship parents. The goal was to reduce depression, anxiety, PTSD, and behavior problems in foster youth aged 4 to 21. Researchers focused on underserved and rural communities in Oregon. The program teaches …

This study tested a new online program (iACTforDGBI) for people with disorders of the gut-brain interaction, like IBS, who also have anxiety or depression. 30 participants tried the self-guided sessions and gave feedback through interviews and questionnaires. The goal was to see …

This study followed 2,365 adults from urban areas of Chile for 12 months to learn more about chronic pain and its effects. Researchers looked at how chronic pain relates to mental health issues like depression and anxiety, as well as work stress and daily functioning. The goal wa…

This study tested a training program called First Face for Mental Health, designed for staff at a Native American healing lodge. The training teaches people how to spot and respond to mental health crises and connect others to help. Researchers surveyed 92 trainees before, right …

This study looked at whether offering cash rewards and sharing screening results could encourage college students in Chennai, India, to use free mental health services. About 340 women students were split into four groups: some just got information, others also learned their scre…

This study analyzed electronic medical records of nearly 920,000 Canadian adults to see how the COVID-19 pandemic affected primary care for chronic conditions like diabetes, heart failure, and depression. Researchers compared care before and during the pandemic, looking at visits…