Ketamine shows promise for Post-Surgery depression in small trial

NCT ID NCT06060210

Completed Symptom relief Sponsor: Benha University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether a single dose of ketamine, given during spinal surgery, can reduce depressive symptoms afterward. 110 adults with moderate to severe depression received either ketamine or a saltwater placebo. The goal was to see if ketamine could lower depression scores by more than half within a week. The trial is complete, and results may show whether ketamine is a safe and effective option for managing post-surgery mood.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketamine
What this could lead to: If it works, this could point toward a simple way to reduce depression after surgery, improving recovery and quality of life.
What could go wrong: This is a small, completed Phase 4 trial. The results may not apply to all surgeries or depression types, and ketamine can cause side effects like high blood pressure or hallucinations.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety disorder Depression mixed anxiety and depressive disorder pseudotumor cerebri

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEPRESSION, ANXIETY

Contacts and locations

Locations

Banha faculity of medicine

Banhā, Elqalyoubea, 13511, Egypt

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