Anxiety disorder

This study tests whether a longer, family-involved form of cognitive behavioral therapy (CBT) can work as well as CBT combined with an antidepressant (SSRI) for children and teens with anxiety disorders. Participants aged 7 to 17 with separation, generalized, or social anxiety wi…

This study tests whether measurement-based care — where therapists regularly track symptoms using questionnaires — adds extra benefit to weekly psychotherapy for adults with depression or anxiety. Participants are randomly assigned to measurement-based care, standard therapy, or …

This study is testing the long-term safety and effectiveness of a drug called TSND-201 for adults with PTSD. Participants who completed an earlier blinded trial of TSND-201 can receive up to three treatment courses over 48 weeks, each consisting of four weekly doses. The goal is …

This study looks at whether starting a cardiac rehabilitation programme soon after leaving the hospital helps people with coronary artery disease live longer and avoid hospital stays for heart problems. The programme includes counseling, education, and exercise sessions three tim…

This study tests whether a trauma-informed program called Strength at Home works better than the usual state-approved program for reducing intimate partner violence. About 800 men who are court-ordered to attend such programs, along with their partners, will take part. Researcher…

This phase 2 trial tests a new drug called HB-1, which combines two blood pressure medicines (telmisartan and verapamil), to see if it can reduce unexpected panic attacks in people with panic disorder. The study plans to enroll 240 adults aged 18 to 65 and compare HB-1 against pl…

This study tests whether offering PTSD therapy to people in jail who also have opioid or stimulant use disorder can help them start addiction treatment after release. Researchers will screen and refer participants, then randomly assign some to start therapy immediately in jail an…

This study tests a personalized deep brain stimulation (DBS) approach for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten adults will first undergo brain mapping to find the best stimulation targets, then receive a DBS dev…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study follows about 1,756 adults who were part of a larger trial and received either ketamine or etomidate during emergency intubation. Researchers want to see if ketamine can reduce PTSD symptoms one year later, since it may block the brain's formation of traumatic memories…

This early-stage study is testing whether combining standard psychiatric medications (like antidepressants and anti-anxiety drugs) with individual cognitive behavioral therapy can improve symptoms and daily functioning in people with anxiety, depression, PTSD, OCD, bipolar disord…

This study tests a program called Minds and Mentors that combines mindfulness training with peer support to help people stick with their medication for opioid use disorder. About 240 adults currently on medication like methadone or buprenorphine will be randomly assigned to eithe…

This pilot study is testing whether adults with serious mental health issues like psychosis, anxiety, or depression can receive hospital-level care in their own homes. Researchers will see how many people are eligible and willing to try this approach. The goal is to offer a safe,…

This study tests whether intensive home-based psychiatric treatment can help children and teens with mental health disorders as an alternative to being in the hospital. Over 3 months, participants receive 3 to 7 home visits per week from a team of doctors, therapists, and other s…

This trial tests a nurse-led health program for women aged 45 to 64 in Hong Kong. The program uses a 5-step approach (ask, advice, assess, assist, arrange) to help women manage conditions like high blood pressure, anxiety, and menopause symptoms. Researchers will compare the prog…

This study looks at whether a therapy called RRFT, which treats substance use and PTSD together, works better than standard separate treatments for teens aged 13-18. About 212 teens with both conditions will be randomly assigned to RRFT or usual care, and tracked for a year. The …

This study tests a phone-based care management program for adults with depression, anxiety, or risky drinking. Participants get regular check-ins and support from a mental health technician, while their primary care doctor receives treatment recommendations. The goal is to see if…

This study compares two ways to help people with both substance use and mental health disorders: a full team-based program called MISSION that provides counseling, peer support, and community outreach for 6 months, versus just linking them with a peer specialist. Researchers hope…

This study tests a new way of delivering mental health and addiction services to youth aged 14-17. Instead of standard hospital outpatient care, an integrated team offers rapid access to various services like therapy, peer support, and primary care in a youth-friendly setting. Re…

This study tests whether mindfulness-based therapy can help people with obsessive-compulsive disorder (OCD). Researchers will compare mindfulness to standard cognitive behavioural therapy (CBT) in 420 adults with OCD. The goal is to see if mindfulness reduces OCD symptoms and to …

This study tests whether painting roofs with a special reflective coating can lower indoor temperatures and improve mental health. About 800 people in Ahmedabad, India, who live in homes with poor insulation will be randomly assigned to get a cool roof or not. Researchers will me…

This study looks at whether having a trained peer (someone with similar experiences) as a case manager can help people with HIV who also have mental health or substance use problems get the care they need. About 405 adults from an HIV clinic will be randomly assigned to either us…

This study compares a structured group exercise program called Braining with standard advice to exercise on your own. Over 12 weeks, 208 psychiatric patients will attend up to three clinician-led exercise sessions per week. Researchers will measure physical activity, depressive s…

This study tests deep brain stimulation, a device that sends electrical pulses to specific brain areas, for people with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Only 2 participants are enrolled. The goal is to see if this approach …

This study aimed to improve how deep brain stimulation (DBS) is targeted for people with severe obsessive-compulsive disorder (OCD). It planned to use brain scans to personalize the placement of electrodes. However, the trial was withdrawn before enrolling any participants, so no…

This early study tests whether brexanolone, a drug already approved for postpartum depression, can safely reduce stress-induced alcohol use in 25 adults with both PTSD and alcohol use disorder. Participants receive a continuous 20-hour IV infusion under medical supervision. The m…

This study aimed to see if the blood pressure drug propranolol could reduce PTSD symptoms in adolescents by blocking the reconsolidation of traumatic memories. Participants would have taken propranolol or a placebo before briefly recalling their trauma, once a week for six weeks.…

This study tests whether adding N-acetylcysteine (NAC) to standard treatment can help people with obsessive-compulsive disorder (OCD) that hasn't improved with other medications. Researchers will measure brain glutamate levels and symptom changes in 90 participants over 12 weeks.…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests whether a Turkish translation of the Four-Dimensional Symptom Questionnaire (4DSQ) helps Belgian general practitioners who don't speak Turkish better diagnose depression and anxiety in Turkish-speaking patients with language barriers. About 80 patients and their …

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study is testing whether artificial intelligence can analyze a person's speech to help diagnose mental health conditions like depression, anxiety, autism, and schizophrenia. Researchers will record 500 people speaking and compare the AI's predictions to standard clinical dia…

This study tests whether a health promotion program can prevent anxiety and depression in older Latino adults who are at risk. 240 participants will either join a program with group walks and social sessions led by a community health worker, or attend a healthy lifestyles educati…

This study tests whether a short, modified exposure therapy given soon after rape can prevent post-traumatic stress disorder (PTSD) in women. About 166 women who have experienced sexual assault will be randomly assigned to either the brief therapy or standard care. The goal is to…

This study tests whether a workshop led by fellow firefighters can help prevent PTSD, depression, anxiety, and alcohol problems in new firefighter recruits. About 480 trainees will take part in either an emotion regulation workshop or a standard education session during their aca…

This study tests a mobile app called FirstFocus that uses attention training to help first responders in rural areas prevent stress and mental health issues like anxiety and depression. About 80 active first responders aged 18+ with an iPhone will use the app before and after shi…

This study investigates whether using a stress ball during port catheter needle changes can reduce pain, anxiety, and improve satisfaction in cancer patients. Fifty adult oncology patients will be randomly assigned to either use a stress ball or receive standard care. The goal is…

This study tests whether smelling essential oils during skin surgery can reduce the unpleasant smell of burnt flesh from electrocautery and lower patient anxiety. About 111 adults having same-day skin procedures will be randomly assigned to receive either a real essential oil inh…

This study explores whether a new type of group therapy, based on Eastern cultural practices, can help people with anxiety disorders. Researchers will enroll 60 participants aged 15 to 55 to test the therapy's effects on anxiety symptoms. The goal is to see if this approach is bo…

This study tests whether a smartphone app that delivers cognitive behavioral therapy (CBT) can help adults with social anxiety disorder. Participants use the app for 12 weeks, learning skills like cognitive restructuring and exposure exercises. The trial compares app users to a w…

This study tests whether a smartphone app called AIM+ can help juvenile justice officers and other professionals who work with youth in the legal system manage chronic stress, anxiety, and burnout. Over 30 days, participants use the app for short guided meditations and videos. Th…

This phase 2 study is testing whether fluoxetine, a widely used antidepressant, can reduce PTSD symptoms in 800 adults including active-duty service members, veterans, and civilians. Participants receive either fluoxetine or a placebo for 12 weeks, and researchers measure changes…

This study tests an internet-based cognitive behavioral therapy (CBT) program designed to help autistic adolescents aged 11-17 manage anxiety. The program, called LUNA-Adolescent, is parent-led and delivered online, making it easier for families who cannot access in-person therap…

This study tests whether daridorexant, a drug used for insomnia, can reduce PTSD symptoms in 200 adults, including active-duty service members, veterans, and civilians. Participants receive either the drug or a placebo for 12 weeks, and researchers track changes in PTSD severity …

This study looks at two ways to lower anxiety in children aged 3 to 10 who need surgical pins removed from an elbow fracture. One approach removes the pins right after the cast comes off, before an X-ray, instead of after. The other uses a virtual reality headset during the pin r…

This study tests an 8-week online stress management program for health students in Sfax, Tunisia. The program combines cognitive-behavioral therapy and mindfulness meditation through videos, exercises, and motivational messages. Researchers will measure changes in stress, anxiety…

This study tests whether a short video and a 3-week text messaging program can help people who have recently experienced sexual assault. The goal is to see if these tools can reduce mental health problems like PTSD and prevent misuse of opioids and other substances. About 394 adu…

This study compares a shorter therapy focused on guilt (TrIGR) to a standard PTSD therapy (CPT) in 160 U.S. Veterans. The goal is to see if TrIGR is no less effective at reducing PTSD, depression, and guilt symptoms. Participants are randomly assigned to one of the two treatments…

This study looks at whether a peer support program is acceptable and helpful for people with mild depression or anxiety who are starting or receiving hormone care. One hundred participants are randomly assigned to either the peer support group or usual care. The program includes …

This study tests whether a simple ear acupressure technique, called auricular point sticking therapy, can reduce anxiety and improve sleep in women undergoing IVF. 178 women aged 20-45 with anxiety or insomnia will either receive standard IVF care or standard care plus ear acupre…

This study tests whether giving first-time mothers online education about childbirth starting at 30 weeks of pregnancy can lower their risk of post-traumatic stress after delivery. Researchers will enroll 400 women and track their mental health through surveys at 6 weeks and 6 mo…

This early-stage study tests whether psilocybin (the active ingredient in magic mushrooms) can safely help adults with long-term PTSD who are already taking antidepressants. Twenty participants will receive psilocybin, and some will also get trauma-focused talk therapy. The goal …

This study tests an oral medication called MM120 against a placebo in 245 adults with generalized anxiety disorder. Participants take the drug or placebo for 12 weeks, and those who complete may join a 40-week follow-up where everyone gets the active drug. The goal is to see if M…

This phase 3 study tests whether an oral medication called MM120 can reduce anxiety symptoms in adults with generalized anxiety disorder. About 214 participants will receive either MM120 or a placebo for 12 weeks, followed by a 40-week period where everyone can receive MM120. The…

This study tests whether injecting a dextrose (sugar water) solution around nerves in the neck can reduce PTSD symptoms like anxiety and brain fog. Twenty-four adults who have tried at least two medications and two non-drug treatments for PTSD will receive either the injection or…

This study tests a single cognitive behavioral therapy (CBT) program designed to help veterans who struggle with both anxiety (including PTSD) and hazardous drinking. The goal is to see if treating both issues together improves their daily functioning and reduces symptoms better …

This study tests whether a unique music therapy, based on Traditional Chinese Medicine's five-element theory, can help men with depression and anxiety when added to their usual medication. One hundred male inpatients will receive either standard drugs alone, drugs plus regular mu…

This study was designed to test whether a group therapy that uses basic communication skills common to all therapies can help people with depression, anxiety, PTSD, and stress. The therapy avoids specific methods like cognitive-behavioral therapy. The trial was withdrawn before a…

This study tests whether simple distraction tools—a ShotBlocker device and a finger puppet—can reduce pain and fear in children aged 5 to 10 during blood draws. About 90 children will be randomly assigned to use one of these tools or receive standard care. The goal is to see if t…

This study tests a telemedicine program called FOCUS that helps advanced cancer patients manage common symptoms like trouble sleeping, worry, tiredness, and low mood. The program uses counseling techniques delivered through a phone app. Researchers will enroll 120 adults with adv…

This study compares two different remote support programs to see which one helps women feel better after surgery for suspected gynecological cancer. About 160 women will take part, and researchers will measure pain, mood, and sleep quality. The goal is to find simple, at-home way…

This study tests a 7-session, peer-led self-management program for 234 cancer survivors who recently finished treatment with curative intent. The program aims to reduce anxiety and depression by teaching symptom management skills in a group setting. Participants are from central …

This study tests whether a mobile app for PTSD, along with brief weekly support sessions, can help people who are already in treatment for alcohol problems. About 300 adults with both PTSD and alcohol use disorder will use the app or receive standard care. Researchers will track …

This study tests whether tolcapone, a drug used for Parkinson's disease, can reduce symptoms of obsessive-compulsive disorder (OCD) in adults. About 49 people with moderate to severe OCD will receive either tolcapone or a placebo. The main goal is to see if the drug safely lowers…

This study tests a structured 8-session group therapy called Integrated Grief Therapy (IGT) for adults who lost loved ones in the 2023 Türkiye earthquake. 190 survivors were randomly assigned to either the therapy or a waitlist. The goal is to see if the therapy boosts resilience…

This study tests whether chamomile or valerian extracts can reduce dental anxiety in healthy children aged 6 to 10 who need a tooth pulled. Kids are randomly given one of the herbal extracts or a placebo before the procedure. Researchers measure anxiety using child-friendly emoji…

This study tests whether a new type of group therapy, called Group Cognitive Evolutionary Therapy, can help reduce symptoms of depression and anxiety. Sixty-four adults with mild to severe depression will either receive two full days of therapy or be placed on a waiting list. Res…

This study tests whether a new therapy called Emotional Resolution (EmRes) can help reduce anxiety in healthcare workers. About 150 hospital workers with mild to moderate anxiety will either receive EmRes or a mindfulness-based gratitude exercise. The goal is to see if EmRes lead…

This Phase 2 trial tests a single intravenous dose of ketamine in 20 hospitalized teens and young adults with anorexia nervosa or atypical anorexia. Researchers want to see if ketamine helps the brain become more flexible, making it easier to learn new, positive associations with…

This study compares three proven PTSD treatments—talk therapy (prolonged exposure), antidepressant medication (paroxetine or venlafaxine), and their combination—in 304 veterans. Researchers aim to identify which treatment works best for whom, using personalized algorithms. Partic…

This study tests a single online session that teaches a simple coping skill to youth ages 9-17 who are on a waitlist for therapy. The goal is to see if this quick digital tool can help ease symptoms of anxiety, depression, and stress while they wait. About 226 youth and their par…

This study tests a therapy called RETELL that helps people with severe mental illness explore and reshape their life stories. The goal is to improve personal recovery, quality of life, and identity. Twenty adults with conditions like schizophrenia, bipolar disorder, or PTSD will …

This study tests whether a community-based music mindfulness program can reduce anxiety and depression in children aged 8-12 with ADHD or anxiety. Participants attend bi-weekly sessions for 8 weeks, wear fitness trackers, and complete surveys. The goal is to see if this approach …

This study looks at whether a guided relaxation practice called Yoga Nidra can lower stress, anxiety, and sleep problems in nursing students during their hospital training. About 110 fifth-year nursing students will take part. Researchers will measure changes using questionnaires…

This early-stage study is testing whether repeated doses of psilocybin, the active ingredient in magic mushrooms, can reduce symptoms of obsessive-compulsive disorder (OCD). Twenty-eight adults with moderate-to-severe OCD who have not responded to standard treatments will receive…

This Mayo Clinic study is testing whether eating fermented foods like yogurt, kimchi, and sauerkraut can improve gut microbiome diversity in people with long COVID. Forty adults with long COVID symptoms will either add fermented foods to their diet or continue as usual. Researche…

This study tests an 8-week program called Step-CBT that combines physical activity goals with cognitive behavioral therapy for veterans with COPD who also have depression or anxiety. The program is delivered via video calls to make it accessible. Researchers want to see if it is …

This study tests two medications, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. Ninety adults will receive one of the drugs or a placebo before spinal anesthesia. Researchers will measure anxiety levels and pain sc…

This study tests a program called Omnis Salutis for recent veterans with PTSD, depression, anxiety, or substance use disorders. The program teaches veterans to identify their health goals and communicate them to doctors and family. Researchers want to see if it improves social an…

This study tests whether a short, intensive course of cognitive behavioral therapy (CBT) over 2 weeks works better than the usual weekly sessions over 6 months for people with anxiety disorders. 120 adults with conditions like panic disorder, OCD, or PTSD will be randomly assigne…

This study tests a free app called LightBEAM that offers videos, forums, and exercises to help parents manage stress, anxiety, and depression. About 300 Canadian parents of children aged 18 months to 9 years will use the app for 12 weeks. The goal is to see if the app improves pa…

This study planned to see if using virtual reality (VR) before a brain stimulation treatment called TMS could help people with OCD feel more comfortable. It was designed for adults already approved for TMS. However, the study was withdrawn before any participants were enrolled, s…

This study aimed to see if a voice-changing device could make exposure therapy easier for people with PTSD. Patients would read their trauma story aloud while software altered their voice's emotional tone, hoping to reduce distress. The study was withdrawn before any participants…

This study tests an experimental nasal spray called fasedienol for quickly reducing anxiety during a public speaking challenge in adults with social anxiety disorder. About 238 participants will receive either the spray or a placebo and rate their distress levels. The goal is to …

This study tests whether an adapted version of Cognitive Processing Therapy (CPT), delivered via telehealth at syringe service programs, can reduce PTSD symptoms and help people stay on their opioid use disorder medication. Eleven adults who regularly use syringe services and are…

This study is an extension of an earlier trial, testing the safety and tolerability of SPT-300 in 360 adults with major depressive disorder, with or without anxious distress. Participants who completed the prior study will receive SPT-300 for 6 weeks. The goal is to monitor side …

This Phase 2 study is testing whether fluoxetine, a common antidepressant, can safely reduce PTSD symptoms in active-duty service members, veterans, and civilians. About 200 participants will receive either fluoxetine or a placebo for up to 12 weeks. The main goal is to see if PT…

This study tests an experimental drug called SLS-002 to see if it can safely reduce PTSD symptoms in active-duty service members, veterans, and civilians. About 200 participants will receive either the drug or a placebo twice a week for 8 weeks, then once a week for 4 more weeks.…

This study tests a digital cognitive behavioral therapy program (SilverCloud) for Spanish-speaking adults with depression or anxiety. 426 participants will either use the program on their own or get extra support from a peer coach via phone or messaging. The goal is to see if add…

This small early-phase study is testing whether psilocybin, the active ingredient in magic mushrooms, combined with supportive therapy can safely help people with obsessive-compulsive disorder (OCD) that hasn't responded to standard treatments. Ten adults with treatment-resistant…

This pilot study tests whether an 8-week mindfulness program (MBSR) can reduce anxiety, depression, and stress in people with COPD who are already in pulmonary rehab. About 44 participants will be followed for 12 months. The goal is to see if this mind-body approach improves emot…

This study looks at whether having therapy sessions in the morning or afternoon changes how well prolonged exposure therapy works for PTSD. About 52 adults with PTSD will receive 10 weekly therapy sessions via telehealth, either early in the day or late afternoon. Researchers wil…

This study tests whether a physical activity program can help pregnant people with symptoms of depression or anxiety feel better. 88 participants will be given a step goal and wear an activity tracker. The program includes weekly reminders and motivational coaching every two week…

This study looks at whether tapping the skin before a shot (the Helfer Skin Tap Technique) can lower pain and boost comfort during a muscle injection. About 60 adults getting a common painkiller injection will be randomly assigned to either the tap method or standard injection. P…

This study tests whether a virtual reality (VR) program can help people undergoing bone marrow transplants cope with stress and improve their quality of life. About 80 adult patients with blood cancer will be randomly assigned to either receive the VR program plus usual care, or …

This study tests whether a medically supervised 12-week ketogenic diet is practical for 6 adults with PTSD in Germany. The main goal is to see if people can stick to the diet and complete the study. It is not designed to measure how well the diet works for PTSD symptoms, but it m…

This study tests whether an online cognitive behavior therapy (CBT) program can help children aged 8 to 17 with asthma who also feel anxious or worried about their condition. The therapy is designed to improve quality of life, reduce anxiety, and help manage asthma better. The st…

This study tests a mindfulness program (called GEM) delivered through an app and weekly group video calls. It aims to see if young adults (ages 18-24) who have faced early life hardships find the program helpful and easy to use. The study also checks if the program reduces sympto…

This study tests whether a virtual reality program that teaches mindfulness, self-compassion, and understanding others can help people with mood, anxiety, or psychotic disorders feel more at ease in social situations. Researchers are enrolling 174 college students and healthcare …

This study tests whether inhaling essential oils can lower stress and help people relax. Two hundred healthy adults will breathe in either an essential oil or a placebo from an aroma stick during stressful and calming activities. Researchers measure heart rate and self-reported s…

This study adapts Written Exposure Therapy (WET), a brief 5-session treatment, for adolescents aged 12-18 with PTSD. Researchers will first gather feedback from experts and teens, then test the adapted therapy against the standard 12-16 session treatment in 48 teens. The goal is …

This study tests a non-invasive device that gently stimulates a nerve in the ear to see if it can reduce anxiety, improve sleep, and lessen pain and itching in adults recovering from burn injuries. About 60 participants will either get standard physical therapy plus this nerve st…

This trial aimed to test an online version of Acceptance and Commitment Therapy (ACT) for adults with disorders of gut-brain interaction (like IBS) who also have anxiety or depression. Participants would have been randomly assigned to either the ACT program or an online education…

This study looks at whether a non-invasive device that stimulates the vagus nerve can improve anxiety, sleep, pain, and itching in teenagers aged 12-18 who have had burn injuries. About 60 participants will either get this stimulation plus standard physical therapy, or just stand…

This study tests an online cognitive behavioral therapy (CBT) program for university students with mild depression or anxiety. Two hundred students who previously took a mental health survey will receive a tailored internet treatment. The goal is to see if this e-health approach …

This study tests whether a brief digital task can reduce the number of upsetting, involuntary memories that women experience after a traumatic event. About 380 women from Iceland who have at least three such memories per week will be randomly assigned to one of three groups: a me…

This study tests whether listening to specific sound frequencies for just 9 minutes a week can improve mental health. 110 adults with mild anxiety, stress, or depression will either sit in a special sound chamber or use headphones. The goal is to see if this simple, drug-free app…

This study tests whether using a virtual reality headset during PICC line placement can reduce anxiety and pain in cancer patients. About 120 adults will be randomly assigned to either receive VR plus standard care or standard care alone. The goal is to see if this non-drug appro…

This study looks at whether cancer patients can use a self-guided meditation program at home to reduce anxiety and depression. About 35 patients will try techniques like deep breathing or gentle movement for two weeks. The goal is to see if this simple, low-cost approach is pract…

This study tests whether an internet-based self-help program called VIVIM can help university students with anxiety and depression. About 108 students will be randomly assigned to use VIVIM or receive usual support from their university counseling service. They will fill out ques…

This study tests whether a non-invasive device that stimulates the vagus nerve can reduce pain and anxiety and improve quality of life for burn patients during dressing changes. About 96 adults with second-degree burns will be randomly assigned to receive the stimulation before o…

This study tests a guided mental health chatbot called STARS, designed to help young people aged 18-25 in Lithuania who are feeling anxious or depressed. About 262 participants will use the chatbot and researchers will measure changes in their symptoms. The goal is to see if this…

This trial aimed to see if heart rate variability biofeedback training (using a smartphone app) could reduce stress and anxiety in university students as well as or better than guided meditation. The study planned to enroll second- and third-year physiotherapy students and measur…

This study tests a stepped care approach to reduce depressive symptoms in 600 adolescents aged 13-15 from 40 schools in Rawalpindi, Pakistan. First, all students receive a universal intervention delivered by non-specialists. Those who still have symptoms after 3 months get extra …

This study tests a program that combines family group sessions with a virtual peer mentoring program for US-born teens (ages 14-17) whose parents resettled as refugees. The goal is to reduce symptoms of PTSD, depression, anxiety, and behavior problems caused by intergenerational …

This small study tests whether group drumming sessions can improve emotional well-being for parents of autistic children. Ten parents will take part in drumming groups and report changes in anxiety, depression, and feelings of belonging. The goal is to see if making music togethe…

This study tests whether a mild electrical brain stimulation technique called tDCS can improve musical performance and reduce stage anxiety in 24 young orchestra players aged 18-30. Participants receive either real or fake (sham) stimulation before playing a piece, and their perf…

This study tests whether an 8-session intermodal art therapy program can lower depression, anxiety, and stress while improving emotion regulation in nursing students. Forty-four first- and second-year students from Istanbul Atlas University will be randomly assigned to either the…

This study planned to test whether a lidocaine nerve block (SPG block) could reduce anxiety in adults at electronic dance music festivals, compared to a saline placebo. The trial was withdrawn before enrolling any participants, so no data were collected. The approach was experime…

This study tests a brief digital mental health program for people on waiting lists for psychological treatment. About 80 participants will be randomly assigned to one of four groups: a short program (30-40 minutes), a longer version, or control conditions. The main goal is to see…

This pilot study tests whether a short, 5-session writing therapy called Written Exposure Therapy (WET) is practical and helpful for pregnant or postpartum adolescents and young adults (ages 15-24) with PTSD. The therapy involves writing about traumatic experiences with minimal t…

This study tests a brief stepped care program for adults hospitalized after a traumatic injury who show signs of PTSD. The program starts in the hospital and aims to reduce PTSD symptoms and the number of emergency room visits over time. About 424 participants are involved, and t…

This pilot study tests whether using a soft baby carrier for extra physical contact helps mothers with prenatal anxiety or depression feel more connected to their baby. Forty moms in Montreal will either use the carrier or be on a waitlist. Researchers will measure bonding, brain…

This early-phase study looks at whether Emotional Freedom Techniques (EFT) — a practice that combines tapping on acupressure points with counseling — can reduce anxiety, depression, pain, and insomnia in people with cholangiocarcinoma, a rare and aggressive bile duct cancer. Four…

This study looks at whether adding physical exercise to cognitive behavioural therapy (CBT) helps older adults with generalized anxiety disorder more than CBT alone. Fifty-three participants will receive either CBT plus exercise, CBT plus a weekly phone call, or just a phone call…

This study tests a 12-session group therapy program (G-BCBT) for active duty military personnel who have recent suicidal thoughts or a recent suicide attempt. The therapy teaches emotion regulation, cognitive flexibility, and relapse prevention skills. Researchers will measure ch…

This study tests whether combining a mild electrical brain stimulation (tDCS) with virtual reality meditation can help ease anxiety. 52 adults with generalized anxiety disorder or related conditions will receive 12 sessions over two weeks. Researchers will measure anxiety levels …

This study looks at whether music therapy can help children and teenagers with mood disorders who also hurt themselves (called non-suicidal self-injury, or NSSI). About 54 participants will take part, and researchers will use questionnaires, brain scans, and electrical brain acti…

This study explores whether music therapy can reduce anxiety, fatigue, and other symptoms in women with breast cancer who are receiving chemotherapy. Twenty-four participants will take part in weekly group music sessions and use personalized playlists at home, alternating periods…

This study looks at whether using a mindfulness app on a smartphone for 8 weeks can improve mental health in Korean immigrants aged 60 and older. Participants use the app for about 10-15 minutes daily and have weekly check-ins. The goal is to see if the app is easy to use and hel…

This study aimed to see if having a parent appear on a video call during anesthesia induction could reduce children's anxiety as effectively as the sedative midazolam. It was designed for children aged 4 to 8 undergoing outpatient surgery. However, the study was withdrawn before …

This study tests whether wearing virtual reality glasses during IUD insertion can lower pain and anxiety. About 114 women will be randomly assigned to use the glasses or not. Researchers will measure pain on a 0-10 scale and anxiety with a standard questionnaire.

This study tests whether using a virtual reality (VR) relaxation session can lower anxiety in people about to receive electroconvulsive therapy (ECT). Twenty adults already receiving ECT for depression will try VR relaxation, breathing exercises, or no extra relaxation. Researche…

This study looks at whether progressive muscle relaxation exercises can improve sleep, reduce anxiety, and help body image in people with burn injuries. About 100 adults with second-degree burns will either do these exercises twice daily for a week or receive standard care. The g…

This study tests if a therapy called FIRST, which uses five key principles to help youth manage negative emotions, works better than standard therapy. About 212 youth aged 7 to 15 with anxiety, depression, trauma, or behavior problems will take part. The goal is to see if FIRST i…

This study tests whether a device called CES (cranial electrotherapy stimulation) can reduce anxiety symptoms in 200 active-duty military members and their families. Participants receive either real CES or a sham (placebo) device to see if the gentle electrical pulses truly help.…

This pilot study tests two 4-week smartphone treatments for social anxiety, one using psychodynamic therapy and the other cognitive behavioral therapy, both guided by an AI chatbot instead of a human therapist. 90 adults with social anxiety are randomly assigned to one of the two…

This study tests whether a gentle ultrasound beam aimed at the brain can reduce anxiety. 44 people with high or low anxiety will receive either real or fake ultrasound while their reactions to stressful tasks are measured. The goal is to see if this noninvasive technique can damp…

This study tests a community-based program called CRISOL Mente to help Latinos in the Philadelphia area with depression, anxiety, or PTSD. The program uses outreach workers to connect people to mental health care and support. Researchers will measure if symptoms improve after six…

This study tests a brief behavioral therapy program delivered via telehealth (STEP-UP) for children and teens aged 8 to 16 with anxiety or depression. Participants are recruited from community health centers and randomly assigned to either STEP-UP or a referral to local mental he…

This study tests a voice-assisted program using Amazon Alexa to help older adults (65+) with depression and their caregivers. Participants use the program for goal setting, reminders, and other mental health support over 12 weeks. Some participants also receive a guide to help th…

This study tests whether inhaling lavender and lemongrass essential oils through a personal necklace can reduce pain and anxiety during active labor. 70 women in labor will be randomly assigned to receive either the aromatherapy or a placebo (sweet almond oil). Researchers will m…

This study aims to help mothers of babies in intensive care cope with depression, anxiety, and stress while also addressing basic needs like food and housing. About 200 caregivers of infants up to 6 months old will receive emotional support and referrals to community resources. T…

This study is testing a 5-week program of fun activities—like laughter therapy, reminiscing about the past, and brain games—for seniors living in care facilities. Researchers want to see if it helps improve emotional well-being, reduce anxiety, and calm agitated behavior. The pro…

This study tests whether injecting an anesthetic near certain neck nerves (stellate ganglion block) can reduce PTSD symptoms by calming overactive stress responses. About 79 adults with chronic PTSD will receive either the anesthetic or a placebo (saline) injection. Researchers w…

This study tests if a non-invasive brain stimulation technique called TMS can improve the effects of exposure therapy for obsessive-compulsive disorder (OCD) in people aged 12 to 21. Fifty participants will receive either real or fake TMS before therapy sessions over two weeks. T…

This study looks at whether oxytocin, a natural hormone, can boost the effects of a special talk therapy for veterans who have both alcohol use disorder and PTSD. About 175 veterans will get either oxytocin or a placebo along with therapy. The goal is to see if oxytocin helps the…

This study tests an accelerated version of a brain stimulation treatment called TMS for people with depression and anxiety. Researchers want to find the best dose to reduce symptoms. About 70 adults will take part, and the study measures changes in mood using standard questionnai…

This pilot study tests a specific type of drama therapy for people who have both a mental health condition (like depression or bipolar disorder) and a substance use disorder. Ten participants will attend weekly group drama therapy sessions for 12 weeks, then put on a performance.…

This early-phase study at Johns Hopkins University is testing whether psilocybin, the active compound in magic mushrooms, can safely help people with obsessive-compulsive disorder (OCD). Thirty-five adults with moderate to severe OCD who have already tried other treatments will r…

This small, early-stage study tested a high-CBD, low-THC liquid spray for 8 weeks in 12 older adults with mild cognitive impairment or mild-to-moderate Alzheimer's who also had significant anxiety or agitation. The goal was to see if the treatment could reduce these behavioral sy…

This study tests whether a fruit compote made with maqui berry, prebiotics, and probiotics can reduce anxiety and inflammation in 30 university students aged 18-40. Participants eat the compote as part of their normal diet, and researchers measure changes in anxiety levels, stres…

This pilot study tests a new approach for misophonia, a condition where common sounds like chewing or breathing cause extreme distress. Sixty adults with moderate to severe misophonia will learn emotion regulation skills and receive one of two types of brain stimulation (rTMS) ov…

This study tests whether using a special augmented reality (AR) game called Little NIRVANA, along with numbing cream, can help children ages 2 to 8 feel less pain and anxiety when getting an IV in the emergency room. About 130 kids will be randomly assigned to get either the AR g…

This study aimed to see if placing an ice-filled glove finger in the rectum for 5 minutes before a prostate biopsy could lower pain, anxiety, and stress hormone levels. It planned to include 84 first-time biopsy patients, comparing those who got the ice treatment to those who rec…

This early-phase study tested whether ketamine-assisted psychotherapy is safe and feasible for adolescents aged 15-17 with severe posttraumatic stress disorder (PTSD). Five participants were to receive three intravenous ketamine doses paired with therapy sessions over six weeks. …

This pilot study tests a therapy called Positive Affect Treatment (PAT) for Spanish-speaking adults with depression, anxiety, and low positive affect (a lack of joy or interest). Twelve participants will attend 15 therapy sessions over about 4 months, focusing on pleasant activit…

This study tests whether a single type of cognitive-behavioral therapy (CBT) can work for several anxiety disorders, compared to therapies designed for each specific disorder. About 76 adults with panic disorder, generalized anxiety, social anxiety, OCD, or PTSD will participate.…

This early study tests if a non-invasive technique called MRI-guided focused ultrasound can safely reduce symptoms in adults with severe obsessive-compulsive disorder (OCD) that hasn't improved with standard treatments. Ten participants will receive the ultrasound treatment and c…

This study looks at whether a special type of massage therapy, designed to be sensitive to trauma and different cultures, can help refugees and asylum seekers who survived torture or war. About 50 people will either get their usual care plus this massage, or just usual care. The …

This study is testing whether listening to calming classical music twice a day can help women with breast cancer feel less anxious and depressed during surgery and chemotherapy. Researchers will also check if music affects certain substances in the blood linked to stress and nerv…

This study looks at whether adding pelvic floor muscle exercises to deep breathing can help reduce pain during periods in women with primary dysmenorrhea. Forty women will be split into two groups: one doing both exercises, the other only deep breathing. Researchers will measure …

This study tests whether watching a virtual reality (VR) video of an electroconvulsive therapy (ECT) session can reduce anxiety and improve knowledge about the procedure. About 64 adults about to have ECT for the first time will be randomly assigned to either a VR education sessi…

This study tests whether a 12-week supervised group exercise program with music can boost emotional well-being in physically inactive women aged 35-60 who feel stressed or down. One hundred women will be randomly assigned to either the exercise group or a waitlist. Researchers wi…

This study adapts a proven PTSD therapy (STAIR-NT) for people in methadone treatment who also use cocaine and opioids. Researchers will test if the adapted program is practical and acceptable, and whether it reduces substance use and PTSD symptoms. About 80 participants will be r…

This study looks at whether music therapy can lower anxiety and stress in people with severe mental illness who are staying in a hospital unit. Twelve participants will attend 15 one-hour music sessions where they choose songs and talk with a nurse. Researchers will measure chang…

This study is testing whether a virtual, personalized music-based relaxation program can help reduce anxiety in teens and young adults who have finished cancer treatment. About 50 participants aged 15-39 with anxiety will take part in 8 weekly 45-minute sessions. The goal is to s…

This study looks at whether a therapist-guided online therapy program can help teens aged 12 to 17 with obsessive-compulsive disorder (OCD). The program uses cognitive-behavior therapy delivered over the internet. Researchers want to see if it's practical and acceptable, and if i…

This study tests whether using a journaling and mood-tracking app called Mirror can reduce symptoms of depression and anxiety in young adults aged 18 to 25. About 500 participants with mild to moderate symptoms will use the app and report their mood changes over 8 weeks. The goal…

This study tests an internet-based program called iExposure for adults with social anxiety. About 390 participants will try one of three versions of the program to see which works best. The goal is to reduce fear and avoidance in social situations, making it easier to connect wit…

This study compares a new, shorter therapy for Post-Traumatic Stress Disorder (PTSD) to standard treatments. Researchers want to see if the brief approach works just as well at reducing symptoms. About 82 adults with PTSD will take part. The main goal is to measure changes in PTS…

This study compares two low-intensity family treatments for children aged 7-13 with anxiety or obsessive-compulsive disorder (OCD): internet-delivered cognitive behavioral therapy (CBT) and a parent-led reading program. Both are delivered via telehealth and compared to a relaxati…

This study tests whether adding a group therapy called Kiesler Circle Training (KCT) to standard cognitive behavioral therapy (CBT) helps people with depression or anxiety improve their interpersonal skills. About 156 participants will receive either CBT alone or CBT plus KCT. Th…

This study looks at whether watching immersive videos before open-heart surgery can lower patients' anxiety and improve their recovery. About 200 adults scheduled for elective heart surgery will take part. Researchers will measure anxiety using questionnaires and vital signs befo…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can safely help veterans with PTSD. Fifteen veterans will receive two doses of psilocybin in a supervised therapy setting. Researchers will monitor side effects and measure changes in PTSD symptoms.

This small pilot study tests whether giving a brief, non-invasive brain stimulation (rTMS) before cognitive behavioral therapy (CBT) can help people with obsessive-compulsive disorder (OCD) get better results. Ten adults with OCD will receive rTMS to improve thinking skills like …

This study tests a mobile health system (smartwatch and app) combined with a week-long cycling event to help veterans reduce stress and PTSD symptoms. Thirty-six veterans will use the system for two months and participate in the cycling challenge. The goal is to see if this appro…

This study tests whether a gentle electrical stimulation on the skin can improve sleep in veterans with PTSD. The device, similar to a TENS unit, targets two different nerve locations to see which works better. Researchers will measure sleep quality using overnight sleep tests in…

This study tests a therapy called Deep Brain Reorienting (DBR) for people with PTSD. DBR helps patients focus on physical tension linked to traumatic memories. 234 adults will be randomly assigned to either DBR or a waitlist, and researchers will measure changes in PTSD symptoms.

This study compares a one-week virtual talk therapy (Cognitive Processing Therapy) to a five-day relaxation training for reducing PTSD symptoms. About 140 adults with PTSD will participate to see which approach works better and how. The goal is to find faster, more effective ways…

This study tests whether a mindfulness-based childbirth and parenting class can lower anxiety in pregnant women. Sixty women with elevated worry will be randomly assigned to either the mindfulness class or a standard childbirth education class. Researchers will track changes in a…

This study looks at whether unlicensed professionals can successfully provide cognitive behavioral therapy (CBT) to patients in a general hospital. It includes 250 adults with conditions like anxiety, depression, OCD, and PTSD. The goal is to see if this approach improves psychol…

This study looks at whether having a psychiatric service dog makes prolonged exposure therapy work better for veterans with PTSD. About 216 veterans who already qualify for a service dog will be randomly assigned to get the dog right away or later. The goal is to see if the dog h…

This study tests an experimental drug called ONO-1110 to see if it can reduce symptoms of social anxiety disorder. About 100 Japanese adults with the condition will receive either the drug or a placebo for 12 weeks. The main goal is to measure changes in anxiety levels using a st…

This study tests whether a 5-week heart rate variability biofeedback program can lower stress and anxiety in 50 dentistry students moving from classroom to clinic. Participants in the training group practice slow breathing with real-time feedback, while a control group receives n…

This study looks at whether trained service dogs can help reduce PTSD symptoms in military veterans. 150 veterans who already qualified for a service dog are randomly assigned to receive one or to a waitlist. Researchers track their PTSD severity, depression, and overall well-bei…

This study tests whether progressive relaxation exercises and planned education can reduce menopause symptoms, stress, and anxiety in menopausal women. About 144 women will participate, with some receiving the relaxation and education program and others not. The goal is to see if…

This study tests a device called Cereset that plays tones to mirror your brainwaves, aiming to reduce stress, anxiety, insomnia, and depression. About 40 nurses from one hospital unit will use the device. The goal is to see if it improves their well-being and job performance.

This Phase 3 trial tests whether two easy tests—measuring blood pressure changes when standing and eye reactions to light—can predict which veterans with PTSD will respond to the drug prazosin. The study involves 87 veterans and compares prazosin to a placebo. The goal is to pers…

This study tests whether a mobile app called PTSD Coach, with or without brief clinician support, can reduce PTSD, anxiety, depression, and sleep problems in World Trade Center responders living in Florida. About 120 English- or Spanish-speaking responders will be randomly assign…

This study looks at whether one art therapy session can improve mood and reduce symptoms like pain and anxiety in adults receiving palliative care. Twenty patients in a Canadian hospital will fill out short questionnaires before and after a 30-60 minute art session. The goal is t…

This early-stage study is testing a smartphone app called NEAT-O that provides cognitive behavioral therapy (CBT) to adults with opioid use disorder who also have anxiety or depression. The goal is to see if the app is easy to use and acceptable to patients. If successful, it wil…

This pilot study tested whether kava, a herbal supplement, could safely reduce anxiety and stress in 43 cancer survivors who had completed treatment. Participants took either kava or a placebo for 14 days, then switched after a washout period. The trial is currently suspended, an…

This study from Yale University will test whether listening to live music can reduce anxiety and improve brain activity in people with early Alzheimer's disease, dementia, or mild cognitive impairment, along with their caregivers. Sixty pairs (patient and caregiver) will attend b…

This study tests whether placing a colorful, washable walkway mat in front of children's beds can reduce pain and fear and help them start moving sooner after abdominal surgery. About 74 children aged 4–10 will be involved. The mat is designed to distract and encourage kids to wa…

This trial tests whether an AI-based management platform, called 'Zhiliao Doctor,' can reduce anxiety and depression in 300 breast cancer patients taking CDK4/6 inhibitors at home. Participants are randomly assigned to standard care, the AI platform, or personalized follow-up cal…

This study tests whether a virtual, community-based program combining music and mindfulness can help reduce stress, anxiety, and depression in people of African descent. About 300 participants aged 16 and older will take part. The goal is to see if these culturally relevant activ…

This pilot study is testing a group-based cognitive-behavioural therapy (CBT) for people with generalized anxiety disorder (GAD) who have difficulty tolerating uncertainty. The treatment focuses on helping participants face uncertain situations through behavioural experiments. Th…

This study tests a videoconference-based coaching program for testicular cancer survivors to help reduce fear of cancer recurrence and improve quality of life. About 70 survivors will be randomly assigned to either a coaching program based on Acceptance and Commitment Therapy (AC…

This study looks at whether following an anti-inflammatory diet for 4 months can improve symptoms of anxiety and depression in 60 adults. Participants will either follow the special diet or their usual eating habits. The study also uses artificial intelligence to analyze speech a…

This study looks at whether using virtual reality goggles or a kaleidoscope can help reduce fear and anxiety in children aged 4 to 6 during a kidney scan (renal scintigraphy). The scan requires the child to lie still, which can be scary. The study will compare these two distracti…

This study looks at whether virtual reality (VR) therapy or a simple deep rest relaxation technique can help older adults feel less stressed and recover better after hip or knee replacement surgery. About 90 people aged 60 and older who recently had surgery will try one of these …

This study tests a new computer therapy that uses eye-tracking to help people with social anxiety disorder. About 60 adults aged 18 to 60 will try this treatment to see if it reduces their fear and avoidance of social situations. The goal is to find a new, non-drug way to ease sy…

This study tests a 15-session creative writing program called REWRITALIZE for people with serious mental illnesses like schizophrenia, bipolar disorder, or severe depression. About 300 adults will either join the writing groups plus their usual care, or stay on a waiting list wit…

This study tests a special therapy program delivered over the internet for people with mild cognitive impairment or dementia who also feel anxious. The program uses cognitive behavioral therapy (CBT) techniques to help manage worry and fear. Researchers will measure changes in an…

This study tests a remotely delivered 8-week program called ReStoreD for couples where one partner has had a stroke. The program teaches goal-setting, communication, and positive thinking skills to reduce anxiety and depression. Researchers will enroll 400 couples to see if the p…

This study looks at whether a simple hug from a family member before surgery can help lower anxiety and pain afterward. 160 adults having planned surgery will either hug for at least 20 seconds or follow standard care. Researchers will measure anxiety levels and pain scores to se…

This study tests a group therapy called Awareness, Courage, and Love (ACL) for older adults with psychiatric disorders who feel lonely. The therapy focuses on mindfulness, sharing feelings, and building connections. Researchers want to see if the program is practical and helpful …

This study tests a program called FACE-Rare, designed to support family caregivers of children with rare, life-limiting diseases. The program includes three sessions to help families prepare for future medical decisions and improve their quality of life. Researchers will compare …

This study looks at two simple ways to help children feel less anxious and in less pain when getting a tooth pulled. One method uses a fun video to distract them, and the other uses gentle pressure on a specific point on the hand. The study will include 69 healthy children aged 5…

This study looks at whether fun activities like finger puppets, virtual reality glasses, or smartphone games can lower anxiety and pain in children aged 6 to 12 before and after surgery. About 76 kids having planned surgery will be randomly assigned to one of these play methods. …

This study tests a four-session group therapy program called CARE-MI for healthcare workers who may be experiencing post-traumatic stress or moral injury from their jobs. The program combines several evidence-based techniques, including EMDR, acceptance and commitment therapy, an…

This study tests whether a single dose of MDMA, given during a 10-day intensive exposure therapy program, can improve PTSD symptoms more than therapy alone. About 40 adults with PTSD will participate at Emory University. The goal is to see if MDMA helps patients engage better wit…

This study tests whether a short form of talk therapy, called brief prolonged exposure therapy, can help prevent post-traumatic stress disorder (PTSD) in people who have had a spinal cord injury. The therapy involves three one-hour sessions during inpatient rehabilitation. Resear…

This study looks at whether floating in a special tank that reduces outside stimulation can help people with posttraumatic stress disorder (PTSD). About 30 adults with PTSD will take part. Researchers will measure changes in PTSD symptoms, stress, mood, and pain before and after …

This study looks at whether health education from nurses can improve quality of life and reduce anxiety and depression in people who have had digestive surgery and now have an ostomy. About 70 adults with permanent or long-term ostomies will take part in workshops and follow-up s…

This study tests whether a parent-child therapy program can reduce anxiety in 2- to 3-year-old children who are very fearful or shy. About 90 families will take part in remote sessions. The goal is to see if the therapy helps children feel less anxious and keeps improvements for …

This study tests whether a nurse-led education session before surgery can lower patients' anxiety and reduce the risk of agitation when waking up from anesthesia. About 80 adults having elective general surgery will be randomly assigned to receive either the extra education or st…

This Mayo Clinic study tests whether reducing overall smartphone use and avoiding social media apps like Facebook, Instagram, and TikTok can lower anxiety symptoms in adults. One hundred participants with mild anxiety will be asked to change their phone habits, and their anxiety …

This study looks at whether actively caring for plants (like watering and pruning) can lower stress, improve mood, and boost academic motivation in college students. About 87 students will either care for plants on campus, at home, or not engage with plants at all. Over a 16-week…

This study is testing whether CreNeuriS CNS herbal nutrition capsules can safely reduce symptoms of mild depression and anxiety. Thirty adults aged 18 to 65 with both conditions will take the capsules for six weeks. Researchers will measure changes using a standard depression rat…

This study looks at whether pranayama breathing exercises can help people with fibromyalgia feel less pain, anxiety, and sleep better. About 54 adults with fibromyalgia will practice these breathing techniques. The goal is to see if this gentle, low-cost approach can improve qual…

This study tests whether giving children a palm stimulator or a stress ball to squeeze during a respiratory swab can reduce their pain, fear, and distress. About 35 children aged 6 to 12 will be randomly assigned to use one of these tools or receive standard care. Researchers wil…

This study tests a small vibrating device held near the skin during needle sticks (like IVs or blood draws) to see if it lowers pain and anxiety. About 1,100 children and adults will take part. Researchers will watch and ask about discomfort to see if the buzz helps people feel c…

This study tests a 7-week group physical activity program called Confident, Active and Happy Youth (CAHY) for young people aged 8-17 with anxiety or depression. The program includes fun, non-competitive activities led by a therapist. Researchers want to see if it improves mood an…

This study tests whether a program called Bright IDEAS can help parents of children receiving palliative care feel less anxious, depressed, and stressed. The program teaches parents a step-by-step approach to solving problems. Forty parents will take part in 6-8 sessions and repo…

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can reduce alcohol cravings in veterans who also have mild traumatic brain injury or PTSD. Twenty veterans will receive either real or placebo rTMS over 10 sessions in two weeks. The goal is to see…

This study tests whether watching calming nature videos with virtual reality glasses can lower pain and anxiety in people recovering from colorectal surgery. Sixty adults will be split into two groups: one group uses the VR glasses before and after surgery, while the other receiv…

This study looks at whether playing the video game Tetris for 10-15 minutes within 24 hours of an emergency cesarean birth can reduce symptoms of post-traumatic stress disorder (PTSD). 120 women who had an emergency C-section will be invited to play Tetris on a Nintendo Switch. T…

This study tests whether a 6-week online program based on Acceptance and Commitment Therapy (ACT) can help cancer survivors who have finished treatment feel less anxious and depressed. 32 survivors of breast, colon, or rectal cancer will be randomly assigned to either the online …

This study looks at whether breathing in aromatherapy scents can help pregnant women feel less pain, worry, and nausea during labor. About 128 women in labor will either receive the scents or standard care. Researchers will compare their symptoms before and after to see if the sc…

This study planned to test whether virtual reality-based guided mindfulness meditation could help adults with anxiety, depression, stress, or pain feel better. Researchers wanted to see if using VR meditation was practical and if it improved mood and pain scores. However, the stu…

This study tests whether adding transcutaneous electrical acupoint stimulation (TEAS) to standard pain relief can reduce pain and inflammation after lung cancer surgery. 90 people scheduled for thoracic surgery will receive either standard care alone or standard care plus TEAS. T…

This study compares two non-invasive devices that stimulate the vagus nerve—one placed on the neck, the other on the ear—to see which better reduces physical discomfort and health-related anxiety in people with somatic symptom disorder. Sixty participants will try both devices in…

This study planned to test a combination of naltrexone and acetaminophen for treating migraine attacks. It was designed in two stages: first comparing the combo to each drug alone and placebo, then finding the best dose. However, the trial was withdrawn before any participants we…

This study tests a topical patch called PEACE that uses gentle vibrations to help people feel less stressed or anxious. 150 adults aged 18 to 85 who have stress or anxiety will wear either the active patch or a sham (fake) patch for 14 days. Researchers will measure changes using…

This study looks at whether adding 10 grams of fibre to your daily diet for two weeks can improve mental wellbeing, including anxiety, stress, sleep, and mood. Researchers will track changes in 40 healthy adults aged 18-40 using questionnaires. It's a small, early-stage trial to …

This pilot study tests whether daily meditation can improve recovery for children and adults having surgery for kidney stones. Participants will be randomly assigned to either a meditation group or a control group. Those in the meditation group will practice a daily 20-minute gui…

This study tests whether a stellate ganglion block—a numbing injection in the neck—can quickly reduce PTSD symptoms in veterans. About 410 veterans who still have PTSD after trying standard treatments will receive either the real injection or a sham (fake) one. Researchers will m…

This study tests whether a gentle electrical current applied to the scalp (tDCS) can reduce obsessive-compulsive disorder (OCD) symptoms in people who haven't gotten better with standard therapy. 43 adults with severe, long-lasting OCD will receive either real or fake stimulation…

This study looks at whether laughter yoga can lower exam anxiety and improve spirituality in nursing students. About 36 students will do laughter yoga twice a week for 4 weeks, while another group does nothing. Researchers will compare anxiety and spirituality scores before and a…

This study looks at whether foot reflexology can reduce anxiety in adults with anxiety disorders. About 44 people will receive either real reflexology or a fake massage twice a week for 5 weeks. Researchers will measure anxiety levels before, during, and after treatment to see if…

This Phase 3 trial tests whether a nasal spray called fasedienol can quickly reduce anxiety during a public speaking challenge in adults with social anxiety disorder. About 238 participants will receive either the spray or a placebo before speaking. The study also looks at long-t…

This study tests whether showing finger puppets or cartoons to children aged 3-6 before a blood draw can lower their pain and fear. About 120 children will be randomly assigned to one of three groups: finger puppets, cartoons, or standard care (no extra distraction). Researchers …

This study tests whether a 12-week web-based support program can improve wellbeing in adults who survived a cardiac arrest 1 to 3 months earlier. The program includes educational modules, videos, breathing exercises, and a chat forum. Researchers will compare 120 participants who…

This study looks at whether a brain-training technique called neurofeedback can help new mothers who have experienced trauma feel better and manage their emotions. Twenty postpartum women with trauma-related symptoms will try the training alongside their usual care. The goal is t…

This pilot study tests whether a mobile neurofeedback device (MUSE 2) can help new mothers who have experienced trauma feel better and reduce stress. Forty mothers with PTSD symptoms will use the headband at home for 12 weeks, receiving audio feedback to train their brains to sta…

This study tests whether a trauma-informed care plan (TICP) placed in the electronic medical record helps healthcare teams better care for patients with trauma and complex needs. About 200 patients and their clinicians will use the plan, and researchers will measure how acceptabl…

This study tests whether the anti-inflammatory drug celecoxib (Celebrex) can reduce obsessive-compulsive disorder (OCD) symptoms in adults who are already on medication but still struggling. Researchers will use brain scans and blood tests to measure inflammation and see if it pr…

This phase 2a trial tests CYB004, a synthetic version of the psychedelic DMT, combined with talk therapy in 36 adults with moderate-to-severe generalized anxiety disorder. The study aims to see if the drug is safe, tolerable, and can reduce anxiety symptoms compared to an active …

This study looks at whether spending time with a therapy dog can reduce anxiety and stress in graduate students. Thirty first-year grad students will either interact with a therapy dog or receive general health education. Researchers will measure stress through saliva cortisol le…

This study looks at whether two Akashic Records sessions can improve mental health in adults who have felt stressed, anxious, or down in the past year. Participants will attend private video sessions with a therapist and complete surveys about their mood and resilience. The goal …

This study tests a short, acceptance-based therapy (ABBT) to help LGBTQ+ adults with mild anxiety or depression worsened by the COVID-19 pandemic. 240 participants will either receive the therapy or standard care. The goal is to see if ABBT can reduce symptoms and improve social …

This study tests a teaching method called Cooperative Learning, where teens work in small groups with the help of technology. The goal is to see if this approach can reduce anxiety, depression, and suicidal thoughts in 1,200 students. The method is designed to be easy for schools…

This study tests a 16-week cognitive behavioral therapy (CBT) program called the C.A.T Project for Pakistani teenagers aged 14 to 17 with moderate to severe anxiety. The program helps teens change unhelpful thoughts and behaviors using relaxation, problem-solving, and parent educ…

This study tests whether a 30-minute music session can reduce stress, anxiety, and pain in adults recovering from heart surgery. Researchers will measure stress hormones, vital signs, and patient-reported feelings in 120 participants. The goal is to see if music offers a simple, …

This study tests whether using a virtual reality headset (HypnoVR) can help reduce pain and anxiety during labor. Seventy women in Tunis will be randomly assigned to use the headset or receive standard care. Researchers will measure pain and anxiety levels before and after the in…

This study tests whether using a stress ball during a prostate biopsy can help reduce anxiety and pain. Researchers will enroll 66 men undergoing their first prostate biopsy. Participants will squeeze a stress ball during the procedure, and their pain and anxiety levels will be m…

This study tests a stepped care cognitive behavioural therapy (CBT) program for children aged 7-12 with mild to moderate anxiety, delivered in primary care settings. All children start with a brief group intervention, and those needing more support receive additional individual C…

This pilot study explores whether laughter yoga can reduce depression and anxiety in children with autism spectrum disorder (ages 8–12) and lower parenting stress for their parents. 66 families will either take part in laughter yoga sessions or be placed on a waiting list. The st…

This pilot study tests whether a smartphone app called AmDTx can help lung cancer patients manage anxiety before and after surgery. The app includes mindfulness training and a relaxing puzzle game. Only 6 participants are enrolled, and the main goal is to see if people will actua…

This study tests whether a device called transcutaneous auricular vagus nerve stimulation (TaVNS) can reduce anxiety and distress in healthcare workers. Participants wear special earbuds that send gentle vibrations to stimulate the vagus nerve. Researchers will also use brain sca…

This study tests a specially designed coverall for intensive care patients who need to move after surgery. The goal is to see if the coverall helps reduce anxiety, improve comfort, protect physical privacy, and increase satisfaction. Thirty patients will try both the coverall and…

This study tests an online cognitive therapy program, guided by a therapist, to help colorectal cancer survivors who have finished treatment reduce their fear of the cancer returning. The program includes educational text, exercises, and videos. Researchers will compare it to sta…

This study planned to compare three different medications given as nose sprays to children aged 2 to 6 years who needed stitches for a cut. The goal was to see which one worked best for pain and anxiety during the procedure. However, the trial was withdrawn before any children we…

This study tests whether two types of breathing exercises—pranayama and deep breathing—can help reduce pain and anxiety in people recovering from abdominal surgery. 120 adults who had elective abdominal surgery will practice these exercises every 2 hours starting 4 hours after th…

This study tests whether a mobile app called OkeyMind can reduce social anxiety and depression in young people aged 15 to 24. The app provides psychoeducation and guided meditation over one month. 180 participants will be randomly assigned to use the app immediately or wait three…

This study tests whether using a kaleidoscope can reduce pain, anxiety, and fear in children aged 6-14 with cancer who are getting subcutaneous injections. The kaleidoscope is used as a distraction during the procedure. The study involves 72 children and compares their pain and f…

This study tests whether showing educational videos to children aged 4-7 and their parents before a blood draw can lower the child's pain, fear, and anxiety. About 76 children will take part, and researchers will measure their distress using standard scales. The goal is to find a…

This study compares two internet-based cognitive behavioral therapies for people with generalized anxiety disorder. 400 adults will receive one of two 10-week online programs, guided by a psychologist. The goal is to see which therapy reduces anxiety more and whether they work by…

This study tests a new online program called Tiny Heroes, designed to help parents of anxious children aged 3 to 6. The program teaches parents cognitive behavioral therapy techniques through four online modules. Researchers want to see if it is practical and effective in reducin…

This study investigates how the brain's emotion network works by recording brain activity directly from the surface of the brain in people with epilepsy who are already undergoing surgery for seizure monitoring. Participants watch short video clips designed to trigger emotions li…

This study tracks 130 adults with PTSD from childhood trauma as they undergo Cognitive Processing Therapy. Researchers will measure brain activity, genetics, and behavior before and after treatment to understand how recovery happens. The goal is to uncover biological markers of P…

This study surveys over 21,000 nurses at Mayo Clinic to measure levels of moral distress, moral injury, and post-traumatic stress. Participants fill out questionnaires about their experiences and well-being. The goal is to understand how these issues vary by work setting, special…

This study looks at how childhood abuse and neglect change the brain in women with PTSD or dissociative identity disorder. Researchers will use MRI scans and cognitive tests to measure brain activity related to attention, emotions, and feelings of detachment. The goal is to bette…

This study aims to find genes that may increase the risk of developing bipolar disorder. Researchers are collecting DNA and health information from 4,185 adults to understand the genetic causes of the condition. The goal is to improve diagnosis and treatment in the future, but th…

This study looks at how children with cancer and their parents handle the emotional challenges of the disease. Instead of focusing only on negative effects like posttraumatic stress, researchers also explore positive changes, such as personal growth. The study compares these fami…

This study looks at whether taking short walks throughout the day is better for kids at risk for type 2 diabetes than one longer exercise session. Researchers will measure blood sugar, insulin, and thinking skills in 188 children aged 8-11 with overweight or obesity. The goal is …

This study tests a 10-week program called 'Grow to Recovery' for people with mental illness. The program is co-led by a peer (someone who also has a mental illness) and a professional. Researchers want to see if it helps participants feel more hopeful and capable. 138 people are …

This study uses PET and MRI scans to measure brain cell connections in people with major depression or PTSD. Researchers will give ketamine to see if it can reverse synaptic loss linked to these conditions. The goal is to understand brain changes, not to provide treatment. About …

This study looks at how fear of pain affects movement in 26 healthy adults. Researchers used verbal suggestions and inactive electrodes to create a sense of threat during walking and arm-pointing tasks. The goal is to understand how fear of movement changes walking speed, stride,…

This 10-year study follows 1,500 young people aged 10-24 to learn what makes some more resilient to depression and anxiety than others. Researchers will track lifestyle, brain scans, and mental health over time. No treatments or interventions are given—the goal is simply to obser…

This study follows 300 Hispanic and Latino caregivers of relatives with memory problems or dementia. Participants complete daily surveys for three weeks at a time, plus follow-ups at six and twelve months, to track how their mood and stress change day-to-day. The goal is to ident…

This study looks at how internet habits, cyberbullying, and emotional coping skills relate to mental health in young people aged 15 to 24. Researchers will survey 50 participants about their internet use, depression, anxiety, and self-harm thoughts. The goal is to better understa…

This study aimed to see if music therapy and mindfulness meditation could help people who had coronary artery bypass surgery improve their blood pressure, heart rate, anxiety, and depression. It planned to enroll 48 adults who had the surgery and were stable. However, the study w…

This study aimed to see how MDMA changes brain activity in people with PTSD, especially in areas that handle emotions. Researchers planned to give MDMA to a small group and measure brain scans and PTSD symptoms. However, the study was withdrawn before any participants were enroll…

This study uses smartphone data to understand what triggers anxiety and alcohol use in each person, then tailors therapy to those specific triggers. 81 adults with anxiety and alcohol problems will receive 11 sessions of cognitive behavioral therapy (CBT) either personalized to t…

This study observes 35 people in residential treatment for substance use disorders to measure behavioral rigidity—the tendency to get stuck in inflexible thinking patterns. Participants complete weekly questionnaires and have their therapy sessions analyzed for language patterns.…

This study is testing whether regular cognitive activities (like video games and book clubs) and physical exercises (like walking and Zumba) can slow down age-related decline in thinking and physical health. Researchers are following 400 healthy Malaysian adults aged 60 and older…

This study is testing whether a simple saliva test can help doctors choose the right psychiatric medications for children and teens aged 6 to 24. The test looks at the child's DNA to predict how they might respond to different drugs. Researchers hope this will lead to fewer side …

This study tests whether a Norwegian clinic (NSAC) helps people with common mental health issues or muscle pain return to work sooner. 2500 adults are split into three groups: one gets treatment quickly, one waits 10-14 weeks, and one gets a basic check-up. Researchers will track…

This study was designed to test whether a technique called self-distancing—where children refer to themselves in the third person (e.g., 'Emily can touch the spider')—helps them approach feared objects more than using first-person self-talk ('I can touch the spider'). The trial p…

This study looks at whether having a licensed counselor available can improve the mental well-being of medical residents (doctors in training). The researchers will measure changes in well-being, depression, and anxiety. 21 internal medicine residents from the University of Nevad…

This study looks at why adults with cancer may fear taking opioid pain medication after surgery. Researchers will use questionnaires to measure barriers, fears, and medication adherence in 50 patients. The goal is to learn more about these concerns to improve pain management afte…

This study tests whether an early assessment of activity limitations by occupational therapists can help people with mental disorders return to work. 150 participants in specialized psychiatric care will either receive the assessment or usual care. The goal is to see if this lead…

This study looks at whether anxiety and depression are connected to carpal tunnel syndrome in medical students. Researchers will measure the median nerve in the wrist and check students' anxiety and depression levels using questionnaires. The goal is to see if there is a link bet…

This study aims to find better ways to ensure veterans with PTSD, depression, or alcohol/opioid problems receive proven treatments. Currently, only 3-28% of patients get these effective therapies. Researchers will compare a participatory business engineering method (Participatory…

This study explores whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) can reduce compulsive behaviors in people with anorexia nervosa. Twenty participants will receive multiple sessions of rTMS targeting a brain region l…

This study is creating a large registry of 5,000 young people aged 8 to 20 who have depression or suicidal thoughts. Researchers will collect data from clinics across Texas to better understand these conditions and develop models to predict outcomes. The goal is to improve popula…

This study was designed to test the safety and feasibility of a focused ultrasound device called Exablate Neuro with a new Echo-Focusing feature for people with treatment-resistant brain disorders like essential tremor or depression. However, the trial was withdrawn before enroll…

This early study tests an adaptive deep brain stimulation (aDBS) system in 2 people with severe, treatment-resistant OCD. The device records brain signals to identify patterns linked to OCD distress and stimulation side effects. The goal is not to treat OCD now, but to gather dat…

This study tests an adaptive deep brain stimulation (aDBS) system in just 3 people with severe, treatment-resistant OCD. The device is implanted in the brain and chest, and it aims to detect brain signals linked to OCD distress and adjust stimulation automatically. The main goal …

This study was designed to test whether scheduled video calls with a nurse could help family members who make medical decisions for hospitalized older adults with Alzheimer's or similar cognitive issues. The goal was to improve communication and reduce anxiety and depression. How…

This study aims to see if a short, 4-question Turkish version of the Pain Anxiety Symptom Scale is a reliable and valid tool for measuring pain-related anxiety. Researchers will enroll 350 adults aged 18-65 who have had chronic pain for at least 3 months. Participants will fill o…

This study tests a video-based mobile app designed to reduce mental health stigma and medical mistrust among Black adults with moderate to severe depression or anxiety. Participants watch personal stories from others with similar experiences. The goal is to see if this approach i…

This study is testing a digital platform designed to help community health workers (non-specialist providers) feel more confident and skilled when counseling people with anxiety or depression. About 55 English-speaking adults who have already completed a specific training program…

This study interviews 14 veterans who served in combat to create a group therapy program for moral injury—the lasting distress from events that violated their values. The goal is to help them reintegrate into civilian life and restore functioning. The research focuses on developi…

This study looks at whether a fear-inducing virtual reality (VR) experience can change how much empathy people feel. About 110 young adults (ages 18-25) will either experience a scary VR scenario, like walking a plank high above a city, or a neutral one. Researchers will measure …

This study aimed to develop and test a 12-week mental health program designed specifically for young South Asian women aged 16-24 with mood or anxiety disorders. The program was meant to address cultural and gender needs. However, the study was withdrawn before any participants w…

This study tests whether giving doctors a summary of their patient's survey answers before a consultation helps people on sick leave return to work. About 1180 adults in Norway are taking part. The goal is to see if this simple nudge improves recovery and reduces time off work.

This study looks at whether an 8-week program of daily brain training exercises, combined with a gentle electrical current applied to the scalp (tDCS), can improve thinking, reduce falls, and help seniors with mental health conditions stay independent. About 270 older adults livi…

This study tests whether a 12-week program that combines brain training, social activities, and exercise is practical and liked by seniors with mental health conditions living in community housing. About 18 participants will try the program in small groups, guided by a support wo…

This study tests whether a culturally tailored mobile health program can improve mental health and pregnancy outcomes in Black pregnant women. Half of the 150 participants will receive the program, which builds communication and self-advocacy skills and provides support. The goal…

This study is developing and testing a smartphone app called R-Assist for people recently released from jail who have both substance use and mental health disorders. The app tracks symptoms, connects users to resources like housing and recovery groups, and measures how easy it is…

This pilot study uses functional MRI to examine brain activity in trauma-exposed veterans with obsessive-compulsive personality traits, known as overcontrol. Overcontrol can strain relationships and increase suicide risk. The study aims to test whether the brain scanning methods …

This study planned to find out how often teenagers with juvenile idiopathic arthritis experience chronic pain, especially when their arthritis seems quiet or mild. Researchers wanted to measure pain intensity and how it affects daily life, school, sleep, and social activities. Th…

This study tests a three-session virtual program designed to help U.S. adults improve their social connections, get more involved in their communities, and feel better physically and mentally. Researchers will enroll 200 people who will attend weekly Zoom meetings with trained fa…

This observational study will follow 384 patients in Brazil who are using cannabis-based products (like CBD or THC oils) prescribed by their own doctors for chronic pain, anxiety, or depression. Researchers will not provide the medication but will track patients' quality of life,…

This study involves 2,200 women aged 50–67 to see if personalized mammography screening, based on genetic and lifestyle risk factors, is safe and acceptable. Half the women receive standard biennial mammograms, while the other half get a risk assessment and a tailored screening s…

This study looks at 60 people with obsessive-compulsive disorder (OCD) who either respond well to medication, respond to brain stimulation, or don't respond to either. Researchers will take blood samples and turn them into nerve cells in the lab to study how these cells react to …

This study aimed to enroll 150 people at different risk levels for self-harm to understand how brain activity and blood markers relate to suicide risk. Participants would have received brain scans, blood tests, and three different treatments (neurofeedback, transcranial magnetic …

This study looks at how jaw surgery changes not just your bite and appearance, but also your emotions, jaw muscles, and joint health. Researchers will follow 100 patients before and after surgery, using scans, muscle tests, and questionnaires to track these changes. The goal is t…

This study looks at tobacco, cannabis, and other drug use among homeless and at-risk youth in downtown Ottawa. Researchers will follow 520 participants aged 16 and older who are homeless or insecurely housed and have a history of cannabis use and mental illness. The goal is to un…

This study explores whether a personalized therapy method called Process-based Therapy is practical in regular mental health clinics. About 40 adults with depression or anxiety will try this approach, and researchers will measure how satisfied patients and therapists are with it.…

This study uses health records from about 100,000 people in Israel to see if past viral infections (like Epstein-Barr, COVID-19, or herpes) increase the risk of developing mental illnesses such as depression, anxiety, bipolar disorder, or schizophrenia. It also looks at whether i…

This study explores whether highlighting certain words in questionnaire instructions (like 'bothered by') affects how people with depression or anxiety respond. Two hundred U.S. adults who have been treated for these conditions in the past year will take the same survey twice in …

This study aimed to test a short program called PCIP (Primary Care Intervention for PTSD) for teenagers with post-traumatic stress disorder. The program included relaxation techniques and education, delivered via telehealth. However, the trial was withdrawn before enrolling any p…

This study looks at whether having naturally low testosterone levels increases the risk of dementia, depression, or anxiety. Researchers will analyze genetic data from large biobanks (like UK Biobank) to see if certain genes linked to low testosterone are also linked to these men…

This study investigates whether psychological factors like fear of movement, self-confidence, and mood can predict how much pain and disability improve after manual therapy in people with chronic low back pain. Sixty adults aged 18-65 with pain lasting over 3 months will be split…

This study tests whether a single session of transcranial direct current stimulation (tDCS) can improve the brain's ability to update fear and safety associations in people with anxiety disorders. 140 participants will be randomly assigned to receive either active stimulation tar…

This study looks at whether certain slow brain waves in the prefrontal cortex can be a sign of social anxiety. Researchers will measure brain activity in 30 people with social anxiety disorder while they wait to give a speech. The goal is to better understand the brain's role in …

This study looks at 50 adults with sleep bruxism (teeth grinding during sleep) to understand how it affects sleep, pain, anxiety, and overall health. Researchers will use sleep tests, blood samples, and questionnaires to find links between bruxism and other conditions. The goal i…

This study tests an 8-week school program called INSPIRE, designed to help Indonesian teenagers aged 13-15 learn about mental health, build resilience, and reduce symptoms of depression and anxiety. Trained school counselors deliver the program using lesson plans and activities, …

This study is developing and testing an online training program to teach therapists how to deliver exposure therapy to people with anxiety disorders and OCD. About 56 practicing therapists will try the program and give feedback to improve it. The goal is to see if the training re…

This study was designed to test a holistic education program for stress management in people from colonized English-speaking countries. It aimed to help with conditions like stress, PTSD, anxiety, and fatigue using pastoral counseling and self-care activities. However, the study …

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study looks at whether a supplement made from black rice extract can increase levels of BDNF, a protein important for memory and mood. Researchers will give 12 healthy adults either the supplement or a placebo and measure BDNF in their blood. The goal is to see if this natur…

This study tests a training program for occupational therapists who work with adults who have had a brain injury. The goal is to help therapists better spot and treat anxiety and depression in their patients. Twenty therapists will take part, and researchers will see if they star…

This study tests a new training program called CARE, designed to help therapists build a stronger bond with patients who come from a different cultural background. Forty Asian American participants will receive up to 15 online therapy sessions from therapists trained in this appr…

This study tests a method called SAIA-MH to help clinics in Mozambique better diagnose, treat, and follow up with people who have mental health conditions. Researchers will compare clinics using this approach to those that don't, involving about 155 patients. The goal is to see i…

The Brain Health Registry is an online project that collects information about memory, mood, sleep, diet, and exercise from adults over 18. Participants also take simple cognitive tests online. The goal is to build a large database to speed up research into brain diseases like Al…

This study is surveying 2500 adults from Croatia, Greece, Italy, Slovenia, and Spain to explore how diet, exercise, sleep, stress, and social habits relate to physical and mental health. Participants complete an online questionnaire about their lifestyle and well-being. The goal …

This study looks at whether AI chatbots can improve how much adults know about anxiety and how they feel about it. About 200 people will use either a chatbot or read standard materials for one week. The goal is to see if chatting with AI helps people learn more and feel more conf…

This study compares two types of training for midwifery students: trauma-informed supportive care and universal continuous supportive care. The goal is to see if these programs improve students' confidence in their clinical skills and reduce their anxiety and secondary traumatic …

This study in Nepal tests whether using rapid point-of-care tests for sexually transmitted infections can reduce the overuse of antibiotics for vaginal discharge. About 1,500 women will be split into three groups: standard care, test-guided treatment, or test-guided treatment plu…

This study planned to check how the COVID-19 quarantine affected people who were already seeing a psychiatrist. Researchers wanted to measure PTSD and other mental health symptoms during quarantine and a few months later. However, the study was withdrawn before enrolling anyone, …

This study aims to identify brain-based subtypes of Obsessive-Compulsive Disorder (OCD) and see how they respond to two different targets of repetitive transcranial magnetic stimulation (rTMS). Researchers will use brain scans to measure connectivity in specific networks before a…

This study follows 192 teens aged 12 to 20 who are already receiving either Cognitive Behavioral Therapy (CBT) or Brief Strategic Therapy (BST) for anxiety, depression, or OCD. Researchers will track their progress using questionnaires and interviews over 9 months. The goal is to…

This study will use brain scans to see how cannabis affects inflammation and brain activity in up to 100 U.S. military veterans with PTSD and suicidal thoughts. Participants will take cannabis for 12 weeks and have PET and MRI scans before and after. The goal is to link brain cha…

Researchers at UCLA are studying whether naltrexone, a drug that blocks opioid receptors, can stop reminders of a social support figure from helping people overcome fear. Sixty healthy adults aged 18-35 will receive either naltrexone or a placebo, then undergo a fear extinction p…

This study uses virtual reality to understand how people learn fear and safety. Participants already have a brain implant (RNS device) for epilepsy. They wear a VR headset while researchers measure brain activity, heart rate, and sweat. The goal is to better understand anxiety an…

This research studies a program that places social workers in 25 children's doctor offices across Indiana. The goal is to help doctors spot and treat mental health issues like depression and anxiety sooner. About 575 patients and staff will take part to see if this approach impro…

This study follows 817 military personnel who served in Iraq to see how war affects mental health, thinking skills, and daily life over time. Participants complete surveys and in-person tests on mood, stress, and memory. The goal is to learn how conditions like PTSD develop and c…

This study tests whether coaching family members through phone calls and a web program can encourage veterans with PTSD to start mental health care. About 122 partners or close family members of veterans will receive either standard coaching or an enhanced version with online tra…

This study looks at how regular exercise influences sleep quality, chronotype (whether you're a morning or evening person), and depression symptoms in university students. Researchers will track 54 students from Aydın Adnan Menderes University who exercise regularly, using questi…

This study looks back at 376 patients who received psychedelic-assisted therapy with LSD or psilocybin for depression, anxiety, PTSD, or substance use disorders. Researchers want to see if the intensity of the psychedelic experience is linked to better outcomes. All data comes fr…

This study aimed to see if a drug called LY-2940094 could protect healthy adults from developing depression- or anxiety-like symptoms after stress. Researchers planned to give the drug to participants and then measure their brain responses to rewards and fear. However, the trial …

This study interviews 18 physiotherapists in private practice to understand how they screen for anxiety and depression in patients with chronic neck, shoulder, and low back pain. The goal is to identify what helps or hinders these mental health checks. The study does not test any…

This study is a small survey of 10 adults exploring how nutrition, mental health, and faith-based practices relate to recovery from trauma or PTSD. Researchers want to understand what helps people overcome life challenges after stressful events. The results will be used to design…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…