Common antidepressant fluoxetine put to the test for PTSD relief
NCT ID NCT05948553
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This Phase 2 study is testing whether fluoxetine, a common antidepressant, can safely reduce PTSD symptoms in active-duty service members, veterans, and civilians. About 200 participants will receive either fluoxetine or a placebo for up to 12 weeks. The main goal is to see if PTSD severity decreases and to monitor any side effects, including suicidal thoughts.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fluoxetine (an antidepressant)
What this could lead to
If successful, this could provide a well-tolerated, widely available treatment option to reduce PTSD symptoms.
What could go wrong
This is an early Phase 2 trial with only 200 participants, and the study is currently suspended. Fluoxetine is already used for depression, so its effect on PTSD may be modest or no better than placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Advanced Discovery Research
Atlanta, Georgia, 30318, United States
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Alexander T. Augusta Military Medical Center (ATAMMC):
Fort Belvoir, Virginia, 22060-5285, United States
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Cincinnati Veteran's Affairs Medical Center
Fort Thomas, Kentucky, 41075, United States
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Homestead Associates in Research, Inc.
Miami, Florida, 33032, United States
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Madigan Army Medical Center
Joint Base Lewis McChord, Washington, 98433, United States
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Tripler Army Medical Center (TAMC)
Tripler AMC, Hawaii, 96859, United States
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Upstate Clinical Research Associates, LLC
Williamsville, New York, 14221, United States
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Walter Reed National Military Medical Center (WRNMC)
Bethesda, Maryland, 20889-5632, United States
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Wilford Hall Ambulatory Surgical Center (WHASC)
San Antonio, Texas, 78236, United States