Common antidepressant fluoxetine put to the test for PTSD relief

NCT ID NCT05948553

Terminated Symptom relief Sponsor: Global Coalition for Adaptive Research Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 study is testing whether fluoxetine, a common antidepressant, can safely reduce PTSD symptoms in active-duty service members, veterans, and civilians. About 200 participants will receive either fluoxetine or a placebo for up to 12 weeks. The main goal is to see if PTSD severity decreases and to monitor any side effects, including suicidal thoughts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fluoxetine (an antidepressant)
What this could lead to: If successful, this could provide a well-tolerated, widely available treatment option to reduce PTSD symptoms.
What could go wrong: This is an early Phase 2 trial with only 200 participants, and the study is currently suspended. Fluoxetine is already used for depression, so its effect on PTSD may be modest or no better than placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-TRAUMATIC STRESS DISORDER

Contacts and locations

Locations

Advanced Discovery Research

Atlanta, Georgia, 30318, United States
Alexander T. Augusta Military Medical Center (ATAMMC):

Fort Belvoir, Virginia, 22060-5285, United States
Cincinnati Veteran's Affairs Medical Center

Fort Thomas, Kentucky, 41075, United States
Homestead Associates in Research, Inc.

Miami, Florida, 33032, United States
Madigan Army Medical Center

Joint Base Lewis McChord, Washington, 98433, United States
Tripler Army Medical Center (TAMC)

Tripler AMC, Hawaii, 96859, United States
Upstate Clinical Research Associates, LLC

Williamsville, New York, 14221, United States
Walter Reed National Military Medical Center (WRNMC)

Bethesda, Maryland, 20889-5632, United States
Wilford Hall Ambulatory Surgical Center (WHASC)

San Antonio, Texas, 78236, United States

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