Veterans' PTSD study seeks best treatment match
NCT ID NCT04961190
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares three proven PTSD treatments—talk therapy (prolonged exposure), antidepressant medication (paroxetine or venlafaxine), and their combination—in 304 veterans. Researchers aim to identify which treatment works best for whom, using personalized algorithms. Participants receive up to 14 weeks of treatment and are followed for 40 weeks to track PTSD symptoms, depression, and quality of life.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
paroxetine (Paxil) or venlafaxine XR (Effexor XR)
What this could lead to
If successful, this study could help doctors choose the most effective PTSD treatment for each veteran, improving recovery and quality of life.
What could go wrong
This is a Phase 4 trial comparing existing treatments, so it won't introduce a new cure. Results may not apply to non-veterans or those with different trauma types.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Birmingham VA Healthcare System
Birmingham, Alabama, 35233, United States
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Coatesville VA Medicial Center
Coatesville, Pennsylvania, 19320, United States
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Corporal Michael J. Crescenz VA Medical Center
Philadelphia, Pennsylvania, 19104, United States
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Milwaukee VA Medical Center
Milwaukee, Wisconsin, 53295, United States
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VA North Texas Healthcare System
Dallas, Texas, 75216, United States
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VA Palo Alto Healthcare System
Menlo Park, California, 94025, United States
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VA San Diego Healthcare System
San Diego, California, 92161, United States