Anxiety disorder

This pilot study tests a behavioral program called CBITS-RTM, adapted for teens in juvenile detention. The program combines group and individual therapy to address post-traumatic stress and includes a module on racial trauma. Researchers want to see if it reduces PTSD symptoms an…

This early study tests a mobile health program called WINGS+++ for women who use opioids and have experienced intimate partner violence. The program includes three sessions on a tablet or smartphone with videos, exercises, and a peer navigator to help connect to services. Researc…

This study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…

This study tests a program called NPOWER365 for Black men who have sex with men and are living with HIV. The program uses a smartphone app, online forums, and resource referrals to help with medication adherence, mental health, and access to care. About 350 participants in the At…

This study tests an oral drug called glycerol tributyrate in 24 adults with MELAS or LHON-Plus, two rare mitochondrial diseases that cause severe symptoms like strokes and vision loss. The trial is open-label (everyone gets the drug) and uses each person as their own control over…

This pilot study will test a program that combines a trauma-focused therapy (STAIR) with peer-led HIV prevention (PrEP) support for transgender and nonbinary people who have experienced violence. The goal is to see if this combined approach is acceptable, feasible, and helps impr…

This study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…

This study tests a harm reduction approach for people who use anabolic-androgenic steroids (AAS) without a prescription. Participants will receive four counseling sessions to help them reduce their steroid use and improve their health. The trial will measure changes in steroid us…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…

This study tests a non-invasive procedure that uses sound waves to target a small area in the brain thought to be involved in obsessive-compulsive disorder (OCD). It is for adults aged 25-64 with moderate to severe OCD that has not improved with standard treatments like therapy a…

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This study tests a program called THRIVE for teen mothers in Barbados who are feeling stressed or down. The program includes seven sessions on sexual health, parenting, and life skills to improve mental health and prevent another unplanned pregnancy. Researchers will compare the …

This study tests whether deep brain stimulation (like a pacemaker for the brain) can help people with severe obsessive-compulsive disorder (OCD) that hasn't improved with medication. Four participants will have electrodes implanted and receive stimulation at one of two brain area…

This study will test if a smartphone app that analyzes speech can accurately screen for depression and anxiety in university students. Researchers will enroll 80 students aged 16 to 25 and compare the app's results with standard questionnaires. The goal is to see if voice pattern…

This study explores whether artificial intelligence can help emergency department doctors identify depression and anxiety in patients. Researchers will record 30 adult patients' facial expressions and voice tones as they read a story, and then use AI to analyze those recordings. …

This study will test whether an artificial intelligence (AI) system can diagnose anxiety disorders as accurately as a psychiatrist. One hundred adults with anxiety will be assessed by both the AI and a specialist, and the results will be compared. The goal is to see if the AI is …

This study tests a short, 4-session therapy for burn survivors and their caregivers to prevent posttraumatic stress disorder (PTSD). The therapy, called Promotion of Emotional Disclosure for Burns (PoED-B), helps patients and their loved ones communicate better about the traumati…

This study tests a new media-based program called CONSCIOUS to help men in Nigeria recognize symptoms of mental health issues like anxiety and suicide risk, and encourage them to seek support. The program uses videos or other media to reduce stigma and improve help-seeking. 74 me…

This study tests a mobile app called e-Perinatal designed to prevent depression and anxiety during and after pregnancy. The app offers personalized tips, mental health tracking, and a support button. Researchers will enroll 3,000 pregnant women across primary care centers in Spai…

This study tests whether a 4-hour resilience workshop can prevent PTSD and depression in 800 first responders in New York and Texas. Participants will be randomly assigned to the workshop or a control group and followed for one year. The goal is to see if the training helps them …

This study tests whether an AI-informed peer-mentoring program can help healthy teens and young adults (ages 12-25) manage stress and build social skills, lowering their risk of developing anxiety or depression. Researchers will compare this program to standard mentoring and heal…

This study tests whether digital exercises on a smartphone can help teens aged 16-19 avoid relapse of depression or anxiety. Participants who have recovered from a past episode will use a research app to work through thoughts and feelings while they feel well. Some will join onli…

This study tests whether the blood pressure medication propranolol can prevent post-traumatic stress disorder (PTSD) in women who have experienced sexual violence. 34 women will receive either propranolol or a placebo within 72 hours of the assault, then take it for about three w…

This study in Zimbabwe will screen women of childbearing age and high school students for HPV and Hepatitis B, then offer vaccines to those who are eligible. It also includes cognitive behavioral therapy for mental health issues. The goal is to see if this combined approach can p…

This study tests whether replacing some regular gym classes with specialized physical education courses can prevent common health issues like nearsightedness, overweight, anxiety, and depression in junior high students. Two hundred students will be randomly assigned to either the…

This study tests whether a mobile app that combines digital cognitive behavioral therapy (CBT) with personal mental health coaching can reduce anxiety in adults with hearing or mobility disabilities. Participants use either the active program or a sham version for 8 weeks, with f…

This study tests whether a virtual reality (VR) session the day before gallbladder surgery can lower patients' anxiety and uncertainty about general anesthesia. Two hundred adults who have never had anesthesia will either watch a VR video showing the operating room and anesthesia…

This small study will test whether giving a 15-20 minute massage during infusion therapy can reduce pain and anxiety in women with gynecologic cancer. Twenty-four participants will be randomly assigned to receive either a hand, foot, or neck/shoulder massage or simply talk with t…

This pilot study tests whether a faster schedule of non-invasive magnetic brain stimulation, called accelerated intermittent theta burst stimulation (iTBS), is practical and safe for adults with both PTSD and major depression. Participants receive six short sessions per day for f…

This study tests whether a 15-20 minute virtual reality (VR) relaxation session can reduce anxiety in adolescents aged 12 to 18 during a primary care visit. Participants use the Healthy Mind® VR platform to explore calming environments like beaches or mountains while doing guided…

This study tests whether a device that sends magnetic pulses to a specific brain area (dorsomedial prefrontal cortex) can safely reduce obsessive-compulsive behaviors in adults aged 22 and older. Participants receive either real or sham stimulation over six visits. The main goal …

This study tests whether watching a short educational video before surgery can lower anxiety in adults having elective procedures. Participants are randomly assigned to receive the video via a QR code they scan on their own phone, via a tablet provided in the waiting area, or to …

This study tests whether a short mindfulness exercise, followed by questions that help patients reflect on their experience, can reduce pain and anxiety after knee or hip replacement surgery. Adults who have had a joint replacement will receive a guided breathing exercise via tex…

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This study tests whether a set of four gentle osteopathic manual techniques can reduce stress and anxiety in young adults aged 18 to 35. Thirty participants will either receive the real techniques or a placebo simulation, and researchers will measure changes in heart rate variabi…

This study tests whether using a virtual reality headset (HypnoVR) during interventional radiology procedures can lower patients' anxiety and pain. Seventy adults will be randomly assigned to either use the VR headset or receive standard care. Researchers will measure anxiety wit…

This study tests a 3D-printed 'oxygen support cage' placed over the patient's head during cataract surgery. The cage lifts surgical drapes off the face, which may reduce feelings of suffocation and anxiety. Researchers will measure changes in blood pressure, heart rate, breathing…

This study tests BraveBot, a computer program that talks with young people (ages 12-22) through their phone or computer while they do exposure therapy homework for anxiety or OCD. BraveBot does not replace the therapist but offers real-time coaching and encouragement during assig…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study investigates whether a single session of whole-body hyperthermia (using an infrared sauna) can quickly improve symptoms of depression and anxiety. Researchers will measure brain activity, inflammation, and mood changes in four groups: healthy postpartum women, postpart…

This study will test whether smartphone sensors can detect when someone with early psychosis is feeling anxious or depressed and then offer a short mindfulness or psychoeducation exercise. Ten adults aged 18–50 with early psychosis and mild mood symptoms will use the app for 10 w…

This early-stage trial at the University of Chicago tests whether Adderall, a drug used for ADHD, can improve social interactions in people with PTSD. About 40 adults aged 18-65 will receive either Adderall or a placebo and rate their conversations. The goal is to see if this dru…

This study tests an 8-week group program that combines mindfulness, gentle movement, breathing exercises, healthy eating tips, and art activities for adults aged 55 and older with mild-to-moderate depression or loneliness. The goal is to see if the program improves mood, reduces …

This pilot study tests an 8-week group program designed to improve life balance for parents of preschool children. The program includes group sessions, personal goal setting, and phone check-ins. Researchers will measure changes in life balance, parenting stress, and mental healt…

This study tests a smartphone app that offers short mental health exercises for breast cancer survivors. The exercises target negative thinking, coping skills, and relaxation. The goal is to see if using the app for 8 weeks reduces anxiety and depression symptoms. The study will …

This study tests whether a structured debriefing session within 24 hours after a difficult birth can reduce post-traumatic stress and improve the birth experience. About 142 women who had an unexpected or adverse event during labor will be split into two groups: one gets usual ca…

This study tests whether giving family members of ICU patients a QR code that links to an educational video can improve their understanding of the ICU and reduce their anxiety. Participants are randomly assigned to receive either standard verbal information or the same informatio…

This study tests a two-session Zoom-based therapy designed to change beliefs about mental health treatment in Deaf adults who are not currently in care. Researchers will compare those who receive the therapy to a waitlist group to see if it increases treatment-seeking and reduces…

This study looks at whether adding hypnosis or relaxation sessions to standard psychological care can lower anxiety in children, teens, and young adults who have finished treatment for pediatric cancer. About 558 participants aged 7 to 25 who are in remission and have anxiety wil…

This study tests whether using virtual reality (VR) for mindfulness can help people feel less anxious and experience less pain during minor vascular surgery done under local anesthesia. 160 adults with varicose veins will be randomly assigned to either wear VR glasses with guided…

This trial tests two sedatives—remimazolam and dexmedetomidine—to see which better relieves anxiety while keeping pregnant women comfortable and safe during spinal anesthesia placement for scheduled C-sections. The study includes 150 women at full term and measures success by pat…

This study tests whether giving caregivers hands-on practice plus a video to review at home improves their knowledge, skills, and stress levels when caring for a patient with a feeding tube (PEG). About 54 caregivers will be randomly assigned to either the video-enhanced training…

This study tests two simple, no-cost methods to reduce pain and fear in children aged 6-12 during blood draws: rhythmic skin tapping by a nurse just above the needle site, and the child humming an 'mmmm' sound. Both techniques are based on the idea that touch and vibration can pa…

This study tests a 12-week telehealth program called PARTNER-MH, where trained peer specialists help minoritized veterans navigate mental health care, address social needs, and improve communication with clinicians. The trial will enroll 268 veterans with depression, anxiety, or …

This study tests whether a virtual reality (VR) tour of the hospital and operating room can help children aged 3 to 12 feel less anxious and scared before elective surgery. Half of the 56 children will use a VR program called NixiKit, while the other half will receive the usual p…

This study will test whether foot reflexology—a type of foot massage—can help women aged 18-45 with migraines feel less pain, anxiety, and fear of movement. Twenty women will either receive 10 foot massage sessions over 5 weeks or no massage. Researchers will measure changes in h…

This study tests whether sophrology, a relaxation technique using gentle movements, breathing, and positive visualization, can reduce anxiety in cancer patients undergoing radiation therapy. Fifty-four adults with various cancers will be offered sophrology sessions during their t…

This study tests whether a gentle brain stimulation technique called tACS can make mindfulness therapy work better for people with generalized anxiety disorder. 99 adults will receive either real or fake tACS while doing mindfulness exercises. Researchers will track anxiety sympt…

This study will test whether watching a short educational video or having a standard talk with a doctor is better at reducing anxiety and stress in women scheduled for a planned cesarean delivery. 140 women will be randomly assigned to one of the two groups. Their anxiety levels …

This pilot study will test whether a 6-week app-based mental fitness program can improve wellbeing and self-compassion in anesthesiology residents. Sixty residents will be randomly assigned to either the mental fitness app or a control program. The main goal is to see if such a p…

This study tests a faster version of brain stimulation for generalized anxiety disorder. Instead of weeks of treatment, participants receive five sessions per day for five days. The stimulation is guided by each person's MRI scan to target a specific brain area linked to anxiety.…

This study tests a four-day intensive therapy called Bergen Four-Day Treatment (B4DT) for people with obsessive-compulsive disorder (OCD). About 35 patients will receive the therapy, which involves exposure and response prevention exercises over four days, followed by three month…

This study tests a program called Natural Psychotherapy to see if it can reduce anxiety and depression symptoms in 3,000 Chinese students aged 7 to 18. Participants will be randomly assigned to the program or a control group, and their progress will be tracked for 6 months. The g…

This study tests whether valbenazine can safely reduce symptoms in adults with moderate-to-severe obsessive-compulsive disorder (OCD). About 30 participants will receive either the drug or a placebo in a crossover design, meaning everyone gets both over time. The main goal is to …

This study tests whether structured play activities, done with a parent, can reduce anxiety in children with congenital heart disease before their surgery. About 204 children aged 0-12 will be randomly assigned to either receive therapeutic play plus standard care, or standard ca…

This study looks at whether taking a daily probiotic powder can help adults with overactive bladder (OAB) and anxiety. About 218 people will take either probiotics or a placebo for 12 weeks, while everyone also learns bladder training. The main goals are to see if probiotics redu…

This pilot study will test whether a 'Comfort Tote' filled with items like aromatherapy oils, stress balls, acupressure guides, and a journal can help teens aged 10-21 feel less pain, anxiety, and stress after scoliosis surgery. Half the participants will get a tote with therapeu…

This study tests a sleep treatment called TranS-C, adapted for veterans with PTSD and sleep problems. The goal is to improve sleep, reduce nightmares, and help veterans function better in daily life. 182 veterans will receive either the sleep treatment or usual care to see if it …

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

This study tests whether reading specific self-help books can lower anxiety, depression, and rumination in university students aged 18-25. 110 students from health science programs will be randomly assigned to read one of two books or join a waiting list. Over 8 weeks, they will …

This study will test two smartphone apps, Tankevirus and Grubl, designed to help people with mild to moderate anxiety and depression. About 1000 Norwegian adults will use one of the apps or a placebo app for two weeks. Researchers will measure changes in symptoms and quality of l…

This study compares an AI-delivered digital therapy called Nook to standard cognitive behavioural therapy (CBT) for people with moderate depression and/or anxiety. 400 participants aged 16-64 in the UK will be randomly assigned to either the AI program or human-led therapy. The g…

This study tests whether psilocybin, the active ingredient in magic mushrooms, can help veterans with depression that hasn't improved with at least two other treatments. 240 veterans will receive either psilocybin or a placebo in a controlled setting. The goal is to see if it red…

This pilot study will test whether a weekly 60-minute sound bowl meditation, offered for six weeks, can lower stress and anxiety in unpaid caregivers. Forty adult caregivers who have been helping a chronically ill or disabled family member or friend for at least six months will p…

This study tests whether doing a short 5-minute breathing or mindfulness exercise every day for a month can help Spanish-speaking university students feel less anxious and stressed. 240 participants will be split into four groups, each using a different technique like box breathi…

This study tests a web-based program called MOVED for veterans with PTSD. The program uses videos of kind or brave acts to inspire positive feelings and set personal goals. Over 4 weeks, 250 veterans will either use MOVED or a supportive control program. Researchers will check if…

This study tests whether suvorexant, a medication already approved for insomnia, can help Veterans with PTSD and sleep problems better unlearn fear responses. About 40 Veterans will take either suvorexant or a placebo for 7 nights while researchers measure their skin responses to…

This study looks at two ways to inject botulinum toxin (like Botox) to treat long-term nerve pain from amputation in 100 combat veterans. The goal is to see which method—injecting inside the nerve or around it—works better for reducing pain and improving daily life. Participants …

This study tests whether watching a virtual reality (VR) video before kidney stone surgery can lower anxiety, boost knowledge, and improve self-care. About 90 adults scheduled for surgery will be split into three groups: standard education, standard VR, or a special VR with built…

This study tests whether a stellate ganglion block—a local anesthetic injection near nerves in the neck—can improve sleep and reduce stress in people with PTSD. Sixty adults with PTSD will receive two injections two weeks apart, and their sleep will be tracked with a smart ring f…

This study tests whether a virtual reality (VR) mindfulness program can help reduce anxiety in people who have had a stroke. About 48 adults who had a stroke more than 6 months ago and still feel anxious will use a VR headset for 9 sessions over 3 weeks. The goal is to see if thi…

This study tests whether the psychedelic drug psilocybin, combined with talk therapy, can safely reduce PTSD symptoms in Georgia military veterans. 150 veterans will be randomly assigned to different therapy approaches to compare results. The goal is to see if this combination is…

This study will test an internet-based therapy program for 366 adults with anxiety or depression. The program starts with self-guided modules, and based on early progress, some participants will also get live sessions with a therapist. The goal is to see if personalizing the trea…

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This Phase 2 study tests whether the antidepressant vilazodone can safely reduce PTSD symptoms in 200 active-duty service members, veterans, and civilians. Participants receive either vilazodone or a placebo for 12 weeks, with symptom severity measured using a standard PTSD scale…

This study tests whether watching a short AI-generated educational video before a gynecological exam can reduce women's anxiety and increase their satisfaction. Researchers will enroll 114 women and measure their anxiety and satisfaction levels using standard questionnaires. The …

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study tests whether listening to calming music or using virtual reality can reduce pain, anxiety, and fear in children aged 6-12 with leukaemia who need care for painful mouth sores caused by chemotherapy. Forty-five children will be randomly assigned to a music group, a VR …

This study tests whether a mobile app called SocialRx, which recommends personalized arts and cultural activities, can improve depression, anxiety, and loneliness in teens aged 15-18. About 230 teens with depression or anxiety will either use the app for a year or continue their …

This study looks at whether a counseling approach called 'value clarification' can help women going through menopause feel better. It focuses on reducing symptoms like hot flashes, mood changes, and sleep problems, as well as easing depression, anxiety, and stress. About 88 women…

This study tests whether an AI-enhanced virtual reality cognitive behavioral therapy (VR/AI CBT) program can reduce anxiety and improve quality of life in people with inflammatory bowel disease (IBD). Seventy-six adults with IBD and moderate-to-severe anxiety will be randomly ass…

This study tests whether a warm foot bath combined with relaxation exercises can reduce pain and anxiety when chest tubes are removed after cardiac surgery. Sixty adults who had heart surgery will be randomly assigned to either relaxation exercises alone or relaxation plus a warm…

This study tests whether a specially designed AI chatbot can lower anxiety and trauma-related distress in adults recently diagnosed with cancer. Participants will use the chatbot for 12 weeks and complete surveys about their feelings and needs. The goal is to see if this digital …

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce PTSD symptoms in adults who have survived intimate partner violence. 76 participants will receive either a high or low dose and complete weekly th…

This study tests whether an AI-assisted writing program can help Chinese teenagers (ages 10-19) who are struggling with prolonged grief after losing a loved one. Participants will complete three guided writing sessions over six days, with some receiving personalized AI feedback. …

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can reduce pain, anxiety, and improve vital signs in women after breast surgery. 126 participants will be randomly assigned to one of three groups: pranayama, pursed-lip breathing, or sta…

This study tests a program that combines yoga with cognitive behavioral therapy (CBT) to help people with Generalized Anxiety Disorder. Researchers will measure changes in anxiety levels, psychological resilience, and daily functioning in 64 adults. The goal is to see if this min…

This early-stage trial will test whether psilocybin, the active ingredient in magic mushrooms, can safely reduce symptoms of obsessive-compulsive disorder (OCD). Twenty adults with moderate-to-severe OCD who haven't responded to standard treatments will receive either a low (10mg…

This study tests whether COMP360, a lab-made psilocybin, can reduce PTSD symptoms when given with professional support. About 300 adults with PTSD will receive either a high or low dose and be followed for 8 weeks. The goal is to see if the drug safely eases symptoms like flashba…

This pilot study tests a 12-week mindful eating program called "Eat for Life" in 88 female nutrition students. The goal is to see if it reduces disordered eating, improves body appreciation, and boosts mental health compared to standard nutrition advice. Participants will complet…

This study tests an online platform called PURSUIT that teaches coping skills to Michigan youth aged 8-18 and their caregivers. The program provides cognitive-behavioral techniques for managing pain, stress, and mood, with extra substance use prevention content for teens 12 and o…

This study tests a program called the Brave Elephant Program, designed to help shy preschoolers (ages 3-6) at risk for anxiety. The program trains teachers and uses classroom activities to build social skills and emotional strength. Researchers will check if the program is practi…

This study tests whether a dedicated 30-minute consultation with a healthcare professional before getting an implantable port (a small device under the skin for chemotherapy) can lower patient anxiety. About 150 adults scheduled for the procedure will either get standard care or …

This study tests whether a 10-week virtual group therapy, where people write about their traumatic experiences, can reduce PTSD symptoms in adults who also have borderline personality disorder (BPD) traits. The therapy is called Group Extended Written Exposure Therapy (GE-WET). R…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely help healthcare clinicians who feel depressed and have lost meaning in their work. Seventy-two doctors, nurses, and physician assistants will take part in small groups,…

This study tests whether a therapy that uses MDMA (the active ingredient in ecstasy) can safely reduce post-traumatic stress symptoms in frontline healthcare workers and first responders. About 30 participants will receive the drug alongside talk therapy sessions. The goal is to …

This phase 2 trial tests whether ketamine-assisted psychotherapy (KAP) can safely ease PTSD and trauma symptoms in adults with severe burns covering more than 15% of their body. Twelve participants will receive two KAP sessions plus a preparatory talk therapy session. The main go…

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with expressive writing can reduce post-traumatic stress symptoms in adults. Forty-five participants who have experienced a traumatic event will be split into three groups: rTMS before writing,…

This study will test whether listening to an audiobook before total knee replacement surgery can lower patients' anxiety, blood pressure, and pulse rate. About 93 adults scheduled for elective knee replacement will be asked to use an audiobook app before their operation. Research…

This study tests whether structured spiritual care from a chaplain can reduce anxiety and improve well-being for family members of ICU patients who cannot make decisions for themselves. The chaplain will meet with the family surrogate several times and stay in touch weekly. The t…

This small study will test whether a type of brain stimulation called TMS can help new mothers with obsessive-compulsive disorder that started or worsened after childbirth. Fifteen women will receive 50 sessions over 10 days, along with brain scans and symptom checks. The goal is…

This study looks at whether virtual art therapy can help 62 patients in the coronary intensive care unit (ICU) feel less angry, anxious, and confused. Patients will use a tablet or screen to create art, and researchers will measure changes in vital signs, delirium risk, and menta…

This study looks at whether listening to music can help lower anxiety in adults who have been on a breathing machine for more than 21 days. Two hundred participants will either get standard care or also listen to calming music through headphones for 30 minutes, twice a day, for t…

This study compares two types of therapy for adults afraid of dogs, spiders, or snakes: one uses virtual reality (Doxy.me VR) and the other uses standard photos and videos. Both are delivered via telehealth. Researchers want to see if VR feels more realistic and reduces phobia se…

This study will test whether Emotional Freedom Technique (a type of tapping) and music therapy can reduce stress, anxiety, and depression in women with a high-risk pregnancy due to early rupture of membranes. About 177 women will be randomly assigned to receive these therapies or…

This 12-week study will test whether a daily supplement called Hydrate Heroes can improve brain activity, mood, and thinking skills in 48 healthy adults aged 18 to 65. Participants will take either 3 or 6 packets per day, or no supplement, and will have their brain waves measured…

This study tests a single 90-minute therapy session for teens aged 13-18 who have experienced trauma and are waiting for longer treatment. The session teaches coping skills and understanding of trauma cues. About 40 teens in New Zealand will take part to see if this approach is p…

This study tests a small, non-drug device called ShotBlocker to see if it can reduce pain and anxiety when placing an IV. One hundred adults who need an IV will be randomly assigned to either use the ShotBlocker or receive standard care. The goal is to find a simple, low-cost way…

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study will test whether listening to Turkish music after a planned cesarean section helps reduce pain, anxiety, and improve mother-baby bonding. Seventy first-time mothers will be enrolled. The researchers will measure pain and anxiety levels using standard scales and assess…

This study tests whether listening to self-selected music before, during, and after interventional pain procedures can reduce anxiety, pain catastrophising, and acute pain in adults with chronic pain. 110 participants will be randomly assigned to either music therapy or standard …

This study tests whether short, playful activities—like guided drawing, gentle body movement, and acceptance therapy—can reduce stress and anxiety in university students during exams. Sixty students will participate in a single 20-minute session, and a subgroup will have their br…

This study compares acupuncture with standard medication to see which is more effective and affordable for reducing anxiety and mild to moderate depression in adults in China. About 120 people who haven't had mental health treatment in the past 6 months will choose their preferre…

This study tests whether doing art activities (like drawing or painting) can reduce fatigue, anxiety, and improve quality of life in adults with blood cancers. Fifty-two patients will be split into two groups: one gets six art sessions over two weeks, the other gets standard care…

This early study tests whether a custom video game called Militant of the Maze can make exposure therapy for OCD more effective and engaging. Researchers will first have clinicians play and evaluate the game, then refine it and test it with a few non-clinician volunteers. The goa…

This study tests a structured education program for first-time pregnant women to reduce fear of childbirth and stress, and to strengthen their belief in normal birth. About 72 women in their third trimester will either receive the program or standard prenatal care. The goal is to…

This study tests whether a structured mandala activity program can reduce anxiety and improve emotional well-being in adolescents who have a sibling with special needs. Sixty-four teens will be randomly assigned to either participate in the mandala program or a control group. Res…

This Stanford study tests whether a short virtual reality mindfulness session can improve mental well-being and reduce anxiety in hospitalized adults. 42 participants will try the VR app and also receive standard care, acting as their own comparison. The goal is to see if immersi…

This study tests a non-invasive brain training method (neurofeedback) to reduce anxiety in people with chronic coronary syndrome who are at high risk for heart events. 214 participants will receive either real or sham feedback over 4 weeks. The goal is to see if this approach low…

This study looks at whether combining group cardiovascular exercise with group therapy can help reduce symptoms of anxiety and depression in adults living in rural areas. Twenty participants with generalized anxiety or depressive disorders will take part in a structured program. …

This study tests whether adding diphenhydramine (an antihistamine) to standard sedation medicine reduces pain during first-trimester abortion. About 98 adults will receive either diphenhydramine or a placebo alongside usual care. The goal is to see if this simple addition improve…

This study tests an 8-week mindfulness program designed to help nursing students reduce stress, anxiety, and depression while improving their emotional control. About 93 students will learn meditation, breathing exercises, and mindful movement. The goal is to see if these techniq…

This study tests whether an AI-based rehabilitation program, combined with usual care, can reduce anxiety symptoms more than usual care alone. About 158 adults with anxiety disorders will use the AI system for 12 sessions over 3 weeks. The goal is to see if digital therapy can im…

This study tests whether a single early meeting with a psycho-oncology counselor can reduce anxiety and depression and improve quality of life in people recently diagnosed with cancer. About 148 patients will be randomly assigned to either receive this counseling plus standard ca…

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will either get the program or a general wellness mo…

This study tests a program that offers mental health screening, therapy, and follow-up to pregnant women who are in the hospital for medical complications. About 50 participants will receive brief counseling and symptom tracking during their stay and for three months after. The g…

This study tests whether combining breathing exercises with progressive muscle relaxation can reduce shortness of breath, anxiety, and delirium in patients recovering from heart surgery. 116 adults will be randomly assigned to either receive these techniques plus standard care, o…

This study tests whether an interactive virtual reality (VR) program can help reduce pain, anxiety, and fatigue in 20 hospitalized palliative care patients. Participants use a VR headset with sensors to interact with a calming natural environment for 10 minutes daily over 14 days…

This study will develop and test a digital mental health program called 'VIBE in the Parks' for teens aged 13-24 who use Chicago Park District programs. About 268 participants will either get access to this program or a digital CBT workbook. The goal is to see if the program help…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests an online self-help tool called e-couch for adults with social anxiety. Over 5 weeks, 200 participants will use the program, which is based on cognitive behavioral therapy. Researchers will use surveys and computer tasks to predict who improves the most.

This study tests whether giving a medicine called dexmedetomidine during a second-trimester dilation and evacuation (D&E) can lower the chances of severe grief and post-traumatic stress after the procedure. About 100 people having a D&E in the operating room will be randomly assi…

This study will test if an internet-based cognitive behavioral therapy (iCBT) program can help reduce symptoms of mild-to-moderate anxiety and depression in adults in Singapore. About 390 participants will either receive the 8-week online program with counselor check-ins or conti…

This study tests whether using an animal-shaped magic mirror during vaccination can reduce pain in children aged 1 to 4 years and lower anxiety in their mothers. About 126 mother-child pairs will take part, with some using the mirror and others receiving standard care. The goal i…

This study tests a personalized form of brain stimulation (PrTMS) for PTSD in 100 military veterans. Unlike standard treatments, it uses an EEG brainwave test to customize the therapy to each person. Participants will receive either active treatment or a sham version over 6 weeks…

This study will test whether an open-label placebo nasal spray (a spray with no active ingredients, clearly labeled as a placebo) can reduce stress in 260 adults about to do a canyon swing. Participants will either use the spray or receive no treatment. Researchers will measure s…

This study tests whether using a stress ball or receiving a hand massage during eye surgery can lower patients' anxiety, pain, and stress levels. 174 adults having eye surgery under local anesthesia will be randomly assigned to one of three groups: stress ball, hand massage, or s…

This study tests a supplement called MetaCalm to see if it can help healthy adults feel less stressed quickly. About 280 people will take one of two doses and report their anxiety levels over 6 hours. The goal is to see if MetaCalm lowers stress scores and also affects hunger and…

This study tests a digital therapy that combines unconscious exposure to trauma-related images with bilateral eye movements to reduce intrusive memories in people with PTSD. About 123 participants who experience at least 5 intrusive memories per week will be randomly assigned to …

This study tests whether using a stress ball for 15 minutes before retrograde intrarenal surgery (a type of kidney stone procedure) can lower patients' anxiety and fear, and improve heart rate and blood pressure. Sixty-six adults scheduled for elective surgery will be randomly as…

This study tests whether a short mindfulness program can lower anxiety and improve bonding for mothers whose babies are in the neonatal intensive care unit (NICU). 66 mothers will be randomly assigned to either the mindfulness program or standard care. The program includes four g…

This study will test whether listening to nature sounds or watching virtual reality nature scenes can reduce anxiety and improve comfort and satisfaction for pregnant women during a non-stress test (NST), a routine check of fetal well-being. Researchers plan to enroll 150 healthy…

This study tests whether a short animated video can lower anxiety in children (ages 4-10) getting a stem cell transplant and their parents. Half the families watch the video, the other half get standard verbal instructions. Researchers measure anxiety and satisfaction before and …

This study tests whether a smartphone app called SOLOMIYA is helpful and easy to use for people living under the stress of war in Ukraine. About 80 adults with mild to moderate depression or sleep problems will use the app for a few weeks. The app provides relaxation exercises, m…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests whether squeezing a soft or spiky ball during a blood draw can reduce pain and anxiety in children aged 7 to 12. About 144 kids in a pediatric emergency setting will be randomly assigned to squeeze a soft ball, a spiky ball, or receive standard care. Their pain a…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study tests a new approach to reduce intrusive memories in people with PTSD. Participants are briefly exposed to trauma cues without realizing it, then play Tetris. The idea is to disrupt memory reconsolidation without needing to consciously recall the trauma. The trial will…

This study will test whether sacral massage (a massage on the lower back) can help reduce pain, depression, stress, and anxiety during labor. About 193 first-time mothers with a single, healthy baby will be randomly assigned to receive the massage or standard care. Researchers wi…

This study tests whether playing music through a sound shower in the ICU waiting room can reduce anxiety in family members. 224 adult relatives of intubated patients will be randomly assigned to wait with or without the music. Their anxiety levels will be measured using a standar…

This study tests a smartphone app designed to help teenagers in rural New Hampshire cope with anxiety. The app sends quick, personalized suggestions for calming activities. Fifty teens aged 13-17 with mild or worse anxiety will use the app for 3 months or be placed on a waitlist.…

This study looks at three simple methods—breastfeeding, using a stress ball, or wearing virtual reality goggles—to help first-time mothers feel less pain and anxiety during episiotomy repair (stitching) after giving birth. About 120 women will be randomly assigned to one of these…

This study looks at whether a back massage with mentholated ointment (like Vicks) can lower pain and anxiety in people who just had coronary bypass surgery. 120 adults will be split into three groups: one gets a back massage with mentholated ointment, one gets a back massage with…

This study tests a multidisciplinary program for adults with chronic back pain. Participants will attend group sessions on pain education, healthy habits, and emotional coping, plus do therapeutic exercises. The goal is to see if the program improves physical function, reduces fe…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

This study tests whether a supplement called FibroThol (containing 2-Aticyto Complex and D-ribose) can help reduce pain and other symptoms in people with fibromyalgia. About 200 adults aged 18 to 65 who have had fibromyalgia for at least a year and are already on standard medicat…

Many cancer survivors live with a persistent fear that their cancer will return, which can harm their mental health and daily life. This pilot study will test a type of talking therapy called metacognitive therapy (MCT) against relaxation therapy in 120 survivors. The goal is to …

This study tests whether a personalized AI-generated video, delivered by a nurse avatar, can improve recovery for people after coronary artery bypass surgery. About 128 patients will either get standard discharge instructions or the AI video plus standard care. Researchers will m…

This study tests whether haptotherapy, a gentle touch-based therapy, can reduce anxiety and improve bonding in pregnant women who have had a previous abortion. Eighty women between 28 and 32 weeks of pregnancy will receive five 45-minute group sessions. Researchers will measure a…

This study tests whether 8 sessions of cognitive processing therapy (CPT), delivered online, can help women and birthing people who have post-traumatic stress disorder (PTSD) from a traumatic childbirth. The trial will enroll 29 participants to see if the therapy is practical, ac…

This study tests whether a guided breathing technique called heart rate variability biofeedback (HRVB) can reduce anxiety in 60 adults who are in the ICU waiting for a heart transplant. Participants will use a biofeedback device or app during a single session led by a trained cli…

This study will test whether using technology like virtual reality headsets, tablets with games, or other gadgets can help reduce anxiety and pain in children aged 4 to 17 during minor procedures such as lumbar punctures or heart catheterizations. About 200 kids will be randomly …

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study will test an internet-based therapy program for people with emotional disorders like depression and anxiety. The program teaches skills to manage emotions and is designed to be used at home. Researchers want to see if it works well in primary care settings, if it is co…

This study tests whether taking a daily probiotic supplement for 8 weeks can reduce stress and anxiety in healthy university students during exam time. Two hundred students will receive either the probiotic or a placebo. Researchers will measure changes in stress, anxiety, sleep …

This study tests a device that gently stimulates a nerve in the ear during heart surgery. The goal is to see if it lowers the chance of postoperative delirium, anxiety, and depression. About 270 adults having elective heart surgery will be randomly assigned to receive real or sha…

This pilot study tests an online program for parents of children with hearing loss who have recently had cochlear implant surgery. The program combines education about implant care and communication strategies with Acceptance and Commitment Therapy (ACT) to help parents manage st…

This study tests a two-week intensive summer treatment program for 70 adolescents aged 12-18 with obsessive-compulsive disorder (OCD) in Iceland. The program uses daily cognitive-behavioral therapy with exposure and response prevention in a group setting. Researchers will measure…

This study looks at whether listening to music can help lower anxiety in people having surgery for the first time. Researchers will measure heart rate, blood pressure, and anxiety levels in 90 adults. Some will choose their own music, others will listen to a standard playlist, an…

This study tests whether playing a virtual reality music-movement game can improve mood and social connection in young adults aged 18-25 with mild to moderate depression or anxiety. Participants will be split into three groups: one playing a social VR game with others, one playin…

This study will enroll 400 youth aged 8-18 with chronic medical conditions who have experienced trauma. Participants will first receive group therapy using either SPARCS or UP, two evidence-based talk therapies. Those who still need help after group therapy will then receive indi…

This study tests whether a rapid, 5-day course of transcranial magnetic stimulation (TMS) can reduce PTSD symptoms in veterans. Ninety veterans with chronic PTSD who are still symptomatic despite ongoing treatment will receive either real TMS or a sham procedure. The goal is to s…

This study looks at two simple, drug-free methods—Helfer Skin Tap (gentle tapping near the injection site) and vibration—to see if they can lower pain and fear in children aged 5-10 getting a shot in the emergency room. About 186 children will be randomly assigned to one of these…

This study tests if a therapy called EMDR can reduce post-traumatic stress symptoms in parents whose baby was in the neonatal intensive care unit (NICU). About 80 parents with PTSD symptoms will be randomly assigned to get EMDR right away or after a waiting period. The goal is to…

This study tests a smartphone app called CALM that teaches veterans with traumatic brain injury and PTSD strategies to improve focus, planning, and self-control. One hundred veterans and a family member or friend will be randomly assigned to use the app or receive brain health ed…

This study tests a new, quick brain stimulation treatment for PTSD. Fifteen adults with PTSD will get a brain scan to map their fear and control centers. Then, over 5 days, they receive many short magnetic pulses to strengthen brain connections and reduce symptoms. The study chec…

This study tests whether watching a 360° relaxing nature video through a VR headset during a Pap smear can lower pain and anxiety. Sixty women aged 18–65 will be randomly assigned to either the VR group or standard care. Researchers will measure pain and anxiety levels to see if …

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) during breast cancer surgery can help prevent or reduce negative emotions like anxiety and depression after the operation. About 232 women will receive either real or sham stimulation for 30 minut…

This study tests whether a biofeedback breathing system called Freespira can reduce anxiety and panic symptoms in young people aged 9 to 17. Over 8 weeks, one group uses the device while a control group waits. The goal is to see if the device helps lower anxiety scores on a stand…

This study tests whether a mindfulness training program can reduce depression, anxiety, and stress in pregnant women who did not plan or want their pregnancy but chose to continue it. Researchers will randomly assign 68 women in Turkey to either the mindfulness training or a cont…

This study compares three different oral premedication combinations in 135 children aged 4-12 who are scheduled for day surgery. The goal is to see which regimen helps children tolerate the IV insertion with less fear and distress. Researchers will measure anxiety, pain, and sati…

This study tests whether Emotional Freedom Techniques (EFT) — a simple tapping routine — can reduce anxiety and fear in people about to have thyroid surgery. Seventy adults will be randomly assigned to receive EFT plus standard nursing care or standard care alone. Researchers wil…

This study tests a mobile app called Along With Me to see if it can reduce post-traumatic stress and suicidal thoughts in parents who have recently lost a pregnancy or infant. About 300 participants will either use the app, use the app with support from a peer guide, or receive s…

This study tests an adapted version of a therapy called STAIR-NT, designed to help first responders who have both PTSD and a history of traumatic brain injury. The therapy combines skills training and narrative therapy to address emotional regulation and interpersonal issues. Res…

This study tests whether a structured program where relatives provide sight, sound, touch, and smell stimulation to brain-injured ICU patients can reduce post-traumatic stress in those relatives. 200 family members will be trained and supervised to deliver the stimulation during …

This study looks at whether coloring mandalas (circular patterns) can help reduce anxiety and tiredness, and improve breastfeeding confidence and mother-baby bonding in women who had a C-section. About 140 new mothers will either color mandalas twice a week for 5 weeks or receive…

This study tests a new way to help people going through alcohol withdrawal feel less anxious. It combines hypnosis with aromatherapy, using a calming scent to trigger the relaxation learned during hypnosis. About 80 adults in a hospital addiction unit will either get this combine…

This study looks at whether listening to music can help lower anxiety and improve sleep in people who have had a heart attack and are spending their first night in a special heart unit. About 64 adults will take part. They will listen to music and then use eye masks and earplugs …

This study looks at whether drawing different colors and shapes can help calm adults who are anxious while waiting for surgery. About 175 people scheduled for elective surgery will participate. Researchers will measure their anxiety levels before and after the drawing activity to…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This study tests whether buspirone, a medication used for anxiety, is safe and effective for autistic youth aged 7 to 17 who also have anxiety disorders. Researchers will measure changes in anxiety symptoms over 16 weeks. The goal is to see if this drug can ease anxiety in this s…

This study tests a program called REWIRE for teens aged 12-17 who feel anxious or depressed and use social media over 3 hours daily. The program aims to cut social media use by about half and replace it with positive offline activities like hobbies or time with friends. Researche…

This pilot study will test a 'blended' therapy approach for adults with emotional disorders like anxiety and depression. Participants will either receive standard face-to-face therapy, a mix of face-to-face sessions and a smartphone app, or be placed on a waitlist. The goal is to…

This study tests whether provoking OCD symptoms right before a gentle brain stimulation technique (tDCS) can boost its effects. About 178 adults with treatment-resistant OCD will receive either tDCS alone or tDCS preceded by symptom provocation. The goal is to see if the combined…

This study looks at whether a simple, non-needle ear acupressure technique can lower anxiety and pain in women having breast surgery after a first breast cancer diagnosis. About 66 women will either get standard care or standard care plus ear acupressure. The goal is to see if th…

This study tests whether Emotional Freedom Techniques (EFT) — a therapy that combines tapping on specific body points with focused thoughts — can help people recovering from coronary artery bypass surgery. Researchers will compare 33 patients who receive EFT plus standard care ag…

This study tests whether daily mindfulness exercises—like breathing and meditation—can reduce anxiety, depression, and poor sleep in women going through early menopause. Twenty women in Turkey will be split into two groups: one does mindfulness training for an hour, six days a we…

This study tests whether a four-week virtual yoga program can improve quality of life and reduce anxiety and depression in people going through IVF. About 80 participants will either take weekly yoga classes or continue with their usual care. Researchers will track changes in moo…

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory, attention, and multitasking in veterans with mild traumatic brain injury and PTSD. Forty-six veterans will receive either real or …

This study tests a drama-based coloring storybook called "Alican's Brave Journey" to see if it helps children aged 6-9 feel less fear, anxiety, and pain before and after surgery. 72 children having circumcision will be randomly assigned to either read the storybook or receive sta…

This phase 3 trial tests whether a slow-release form of melatonin can improve sleep in 120 children and adolescents (ages 2-17.5) with PTSD who have significant sleep disturbances. Participants will receive either melatonin or a placebo for 13 weeks. The study aims to see if mela…

This study looks at whether a program combining yoga, meditation, and mindful eating can lower stress, anxiety, and depression in university students. Sixty students will attend weekly sessions for a semester and fill out questionnaires to measure changes. The goal is to see if t…

This study tests whether combining relaxation exercises with listening to a specific Quran chapter (Surah Ar-Rahman) can reduce anxiety and improve sleep in people undergoing kidney dialysis. 76 adult Muslim patients will be split into two groups: one doing the relaxation and Qur…

This study tests whether using a cold spray or a Buzzy device (a vibrating cold pack) can reduce pain and fear during penicillin injections. Ninety adults receiving intramuscular penicillin will be randomly assigned to one of three groups: cold spray, Buzzy device, or standard ca…

This study tests whether atomoxetine, a non-addictive ADHD medication, can improve attention, thinking skills, and quality of life in 160 veterans with PTSD who also have attention problems. Participants will receive either atomoxetine or a placebo for 12 weeks. The goal is to se…

This study tests whether a single session of computer-based cognitive bias modification can reduce social anxiety in 130 Pakistani university students aged 18 to 25. Participants will either receive the active training or a control version, and their anxiety levels will be measur…

This study tests a non-invasive brain stimulation method called cTBS for treating generalized anxiety disorder. 60 adults will receive either real or sham stimulation to two brain areas over 7 days. Researchers will measure changes in anxiety symptoms and brain activity using MRI…

This study tests two non-drug methods—a device called ShotBlocker and a tapping technique called Helfer—to see if they can reduce pain and fear during hormone injections in breast cancer patients. 99 women will be randomly assigned to one of three groups. The goal is to find a si…

This study tests a safe, non-invasive therapy that uses gentle pressure on the arms to improve sleep and mood in people who have had a stroke and suffer from insomnia. The treatment, called remote ischemic adaptation, aims to help the brain recover by briefly restricting and rest…

This study will test if acupressure, music, and virtual reality can help children aged 5-10 feel less pain, fear, and anxiety when getting blood drawn. 120 healthy children will be assigned to one of these methods or standard care. The goal is to find simple, drug-free ways to ma…

This study tests whether a mindfulness-based nursing program can lower anxiety and help stabilize blood pressure in 60 adults undergoing planned open heart surgery. Participants will receive the mindfulness intervention before and after surgery, and their anxiety levels and vital…

This study tests a personalized version of a therapy called Stepped Care Cognitive Behavioral Therapy for children who have experienced trauma. The therapy is adapted for Latino families and involves caregivers helping their children through a step-by-step process. Researchers wi…

This pilot study tests a personalized version of stepped-care cognitive behavioral therapy for PTSD in Latino children aged 7-12. The therapy involves a caregiver-led first step with therapist support, followed by more intensive therapy if needed. The goal is to see if adapting t…

This early-stage study tests a brief couples therapy for 80 Veterans with PTSD and alcohol use disorder. Veterans receive individual treatment while attending 3-4 sessions with their romantic partner. The goal is to see if involving loved ones improves treatment satisfaction and …

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study will test two types of exercise—high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT)—in 68 healthy young adults aged 18 to 21. Over 8 weeks, researchers will measure changes in cardiorespiratory fitness, testosterone and cortisol le…

This study tests whether a handheld palm stimulator can reduce pain, fear, and anxiety when cancer patients get an IV for chemotherapy. About 90 adults will be randomly assigned to either squeeze the device during the procedure or receive standard care. The goal is to provide a l…

This study tests whether a single 'Braining' group exercise session can quickly reduce anxiety in people receiving psychiatric care. Thirty participants will rate their anxiety before and after the session. The goal is to see if exercise can be a fast-acting tool to ease symptoms…

This study compares a new trauma-focused therapy (MBT-TF) with standard therapy for adults who have both borderline personality disorder and complex PTSD. The goal is to see if the new approach is practical and helpful for reducing symptoms. Forty participants will be followed fo…

This study tests whether a short, nurse-guided digital art program on a tablet can lower anxiety and emotional distress in children aged 7-12 in the pediatric ICU. Sixty children will be randomly assigned to either the art program or standard care. Researchers will measure change…

This study tests whether a single 23-30 minute session of specially designed music or pink noise can reduce anxiety in adults with psoriasis. About 120 participants will listen at home using headphones. The goal is to see if audio therapy offers a quick, accessible way to manage …

This study looks at whether electroacupuncture (a type of acupuncture with mild electric pulses) can reduce anxiety in people with Generalized Anxiety Disorder. About 123 adults will be split into three groups: real electroacupuncture, fake electroacupuncture, or a waiting list. …

This study looks at whether community health workers (CHWs) can effectively provide a mental health program to Spanish-speaking Latine parents who have symptoms of depression, anxiety, or traumatic stress. About 52 parents will either get the program right away or after a 5-month…

This study tests whether a 10-week program combining strength exercises with muscle relaxation techniques can reduce frailty, anxiety, and burden in people caring for a loved one with Alzheimer's. About 62 caregivers will be randomly assigned to either the combined program or rel…

This phase 2 trial tests whether low intensity focused ultrasound, aimed at a deep brain region called the amygdala, can ease PTSD symptoms in 60 veterans. The treatment is non-invasive and uses sound waves similar to diagnostic ultrasound. Researchers will measure symptom change…

This study looks at whether listening to guided meditation audio can reduce stress and anxiety in people having open-heart surgery. About 72 adults will either receive meditation sessions or standard care. Researchers will measure stress hormones, blood sugar, and anxiety levels …

This study explores whether aquatic therapy can help veterans with PTSD. Fifty participants will receive 16 weeks of one-on-one sessions in a warm pool, followed by 16 weeks of group exercises. Researchers will measure changes in PTSD symptoms, sleep, and quality of life to see i…

This study looks at whether adding cannabis to standard talk therapy can help veterans with PTSD feel less anxious, depressed, or suicidal. About 280 veterans who have used cannabis before but not recently will take part. Researchers will track changes in PTSD symptoms, brain act…

This study compares hypnosis, virtual reality, and standard care to see which best reduces anxiety in adults starting chemotherapy for acute myeloid leukemia. About 99 patients will be randomly assigned to one of three groups. The goal is to find a non-drug way to help patients c…

This study tests whether a gentle hand-application method called Jin Shin Jyutsu can help perimenopausal women feel better emotionally and physically. Sixty women aged 40-54 will practice the technique daily for two weeks. Researchers will measure changes in quality of life, stre…

This study tests whether using RELAX glasses—a device that plays calming videos and sounds—can lower anxiety in ICU patients during invasive procedures like getting an IV or a catheter. About 456 adults in intensive care will either use the glasses or receive standard care. Their…

This study tests whether EMDR group therapy can help adults who experienced the April 2025 Silivri earthquake in Turkey. Forty participants will be randomly assigned to either the therapy group or a waitlist. Researchers will measure changes in PTSD, depression, anxiety, sleep qu…

This study tests whether internet-based group cognitive behavioral therapy (CBT) delivered over Zoom can reduce symptoms of anxiety and depression in international students in Malaysia. About 128 students with moderate to severe symptoms will be randomly assigned to either the th…

This study tests whether a single low dose of esketamine, given during anesthesia for breast cancer surgery, can reduce severe depression and anxiety symptoms right after the operation. Researchers will enroll 242 women with severe depression who are scheduled for breast cancer r…

This study tests whether acupressure, a technique that applies gentle pressure to specific points on the body, can lower blood sugar and reduce anxiety in people aged 65 and older with diabetes. Forty-eight participants will receive either real acupressure or a sham version for 6…

This study tests whether individual psychotherapy, group therapy focused on body image, or a mix of both can improve quality of life and reduce anxiety in women with endometriosis. Forty women will be randomly assigned to one of three therapy programs or a control group. The goal…

This study tests whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression after the operation. About 218 women having breast cancer surgery will be randomly assigned to receive either esketamine or a placebo during anesthes…

This study looks at whether giving esketamine continuously during breast cancer surgery can reduce feelings of anxiety and depression in patients who already have mild-to-severe depression. About 142 women will take part, and their mood and sleep quality will be tracked after sur…

This study tests a 4-week art-based program that combines relaxation exercises with creative activities like emotion-color mapping and gratitude mandalas. The goal is to see if it reduces anxiety, improves emotion regulation, and lessens symptom burden in 60 adolescents aged 10-1…

This study tests a special type of acupuncture—dense cranial electroacupuncture plus body acupuncture—in 148 teens aged 15-22 with mild to moderate anxiety or depression. Participants receive treatment twice a week for 8 weeks, and researchers measure changes in anxiety, depressi…

This study tests a web-based program called TOUCHMinds designed to help teenagers aged 15-17 who have anxiety symptoms or anxiety disorders feel more comfortable seeking help. The program includes six self-guided online modules and three video sessions with a psychologist. Resear…

This study aims to see if peer support can help pregnant and postpartum veterans who have serious mental illness. Researchers will develop a program where trained peer specialists offer support, then test it with 24 veterans to see if it is helpful and practical. The goal is to i…

This study tests whether a nurse-guided breathing exercise called Pursed Lip Breathing can help people with COPD feel less anxious and have better vital signs (like heart rate and oxygen levels) right after a bronchoscopy. Sixty-four adults with COPD will be randomly assigned to …

This trial tests a non-transdermal biofield patch against a placebo patch in 40 adults who often feel anxious. Over 4 weeks, researchers will measure changes in anxiety, sleep quality, and energy levels. The goal is to see if the patch offers any real benefit beyond a placebo eff…

This study tests whether a special type of acupressure—timed to the body's natural daily rhythms—can improve sleep in nursing home residents aged 60 and older. Eighty participants will receive either real or fake acupressure twice a day for four weeks. Researchers will measure sl…

This pilot study will test whether a smartphone app that teaches cognitive behavioral therapy for insomnia (CBTI) can improve sleep in 144 active-duty service members. Participants will use the app for five weeks, and researchers will measure changes in insomnia severity, depress…

This study tests whether listening to positive self-affirmation audio recordings can help reduce pain, depression, anxiety, and stress in women who have had a mastectomy. Forty-two women will be randomly assigned to either listen to the affirmations or receive standard care. The …

This study tests whether adding virtual reality (VR) sessions to standard counseling helps university students with public speaking anxiety more than counseling alone. About 72 students will be randomly assigned to either counseling only or counseling plus VR exercises that simul…

This study will give 4,400 adults with anxiety a digital brain training program called LENS, which helps people think more positively in uncertain situations. Researchers want to find out why some people improve more than others by looking at genetic and psychological factors. Th…

This study tests a new gel that dissolves tooth decay without drilling, aiming to reduce patient anxiety. Eighty adults with cavities in lower molars will be randomly assigned to either the gel or a standard drill. The main goal is to see which method causes less pain and discomf…

This study looks at whether watching an educational video can lower anxiety in pregnant women who are deciding whether to attempt a vaginal birth after a previous C-section. About 90 women will be randomly assigned to either watch the video or receive standard verbal advice from …

This study compares melatonin, a natural sleep hormone, to midazolam, a common sedative, for calming children before tonsillectomy. About 195 children will receive either melatonin or midazolam before surgery. The goal is to see if melatonin reduces anxiety and confusion after wa…

This study tests two simple, drug-free methods—vibration and breathing exercises—to see if they can reduce pain and anxiety when a chest tube is removed after surgery. About 70 adults will be randomly assigned to vibration, breathing exercises, or standard care. If effective, the…

This study tests whether using a virtual reality headset during labor can help reduce pain and anxiety and make the childbirth experience more satisfying. About 92 women in Taiwan will be randomly assigned to either use VR with calming nature scenes and music or receive standard …

This study will follow 120 people with chronic pain, nerve damage from chemotherapy, radiation side effects, or slow-healing wounds who are referred for ozone therapy. Researchers will track changes in quality of life, pain, and other symptoms over several months. The goal is to …

This study tests whether a simple art activity—coloring mandalas—can reduce anxiety and depression in new mothers. Sixty women who recently gave birth will be randomly assigned to either practice mandala coloring at home for eight weeks or receive standard postpartum care. Resear…

This study will test whether listening to music or chewing sugar-free gum can reduce pain and anxiety during episiotomy repair—the stitching of a cut made during childbirth. Sixty women who have a vaginal birth with an episiotomy will be randomly assigned to one of three groups: …

This study will test a smartphone app called CONEMO in over 12,000 adults visiting primary care clinics. The app uses cognitive behavioral therapy techniques to help reduce symptoms of depression, anxiety, and insomnia. Participants will use the app on their own phones or tablets…

This study tests whether child life services—special support to help kids cope with medical procedures—can reduce pain and fear during skin prick allergy tests. About 140 children aged 1-18 will either receive this extra support or standard care. Researchers will measure pain, ho…

This study tests whether one-on-one sessions with a midwife can help pregnant women feel less anxious about childbirth. About 80 women with high pregnancy-related anxiety will attend 4-6 sessions to learn about birth, pain relief, relaxation, and birth planning. The goal is to lo…

This study will test whether watching a liquid-gel or sand hourglass during blood collection can reduce pain, fear, and anxiety in children aged 5 to 10. About 120 children will be randomly assigned to use one type of hourglass or no hourglass. The goal is to find a simple, non-d…

This study looks at whether using a weighted blanket can reduce nighttime leg cramps, improve sleep quality, and lower anxiety and stress in pregnant women. Fifty women in their third trimester will use the blanket for 14 days and compare results to a 14-day period without it. Th…

This trial will test three simple techniques—box breathing, a cognitive reframing tool called 'Magnify,' and emotion regulation through song lyrics—in 200 middle and high school choir students. Researchers want to see if these music-based interventions can reduce anxiety and impr…

This study tests whether showing 3D hologram videos during burn dressing changes can reduce pain, anxiety, and fear in patients. 70 adults will be randomly assigned to either watch a hologram or receive standard care. The hologram projects interactive images into the air without …

This study tests whether adding a device that turns body movements into sound can help people with acute stress disorder (ASD) feel more connected to themselves. Thirty adults who recently experienced a traumatic event will receive standard therapy plus this 'movement sonificatio…

This study tests whether a short education program can help ICU patients on non-invasive ventilation (a breathing mask) use their machine more regularly and feel less anxious or depressed. About 92 adults will be randomly assigned to either the special training or standard care. …

This study looks at whether playing a guessing game during blood collection can lower fear, pain, and bad feelings in children ages 6 to 12. About 70 kids will take part, and their pain, fear, and emotions will be measured using special scales. The goal is to find a simple, fun w…

This Phase 2a trial will test whether PT150, a drug that blocks a stress-related receptor, can safely reduce PTSD symptoms in 120 US veterans. Participants will receive either PT150 or a placebo for several weeks, and researchers will track changes in PTSD severity and side effec…

This study tests whether very short (4 or 8 sessions) psychological treatments can reduce symptoms of anxiety, depression, and stress-related physical complaints. About 184 adults with mild to moderate symptoms will be randomly assigned to group or individual therapy, or a relaxa…

This study tests whether increasing ward rounds from twice to four times a day, with structured conversations and simple breathing exercises, can lower anxiety in hospitalized patients waiting for therapeutic gastrointestinal endoscopy. About 1,000 adults with mild anxiety will t…

This study tests whether using a virtual reality headset can reduce pain and anxiety when chest tubes are removed after open-heart surgery. Sixty adults will be randomly assigned to either watch a VR video during the procedure or receive standard care. Pain and anxiety levels wil…

This study tests whether inhaling high-THC cannabis can safely reduce PTSD symptoms in 320 veterans. Participants will either receive active cannabis or a placebo with almost no THC. The goal is to see if cannabis helps with PTSD severity and daily functioning, providing real-wor…

This study tests whether wearing virtual reality goggles during a noninvasive bladder test can lower anxiety and improve comfort. Sixty adults aged 30-50 who have never had this test before will be randomly assigned to either watch a 360-degree bathroom scene through VR goggles o…

This study tests whether a digital mental health platform with open peer support can improve quality of life in adults with mild anxiety or depression symptoms. 82 participants will use the platform for 31 days. The goal is to see if their overall well-being, stress, and mood imp…

This study tests whether using a virtual reality headset during a breast biopsy can lower depression, anxiety, and stress. 80 women will either wear a VR headset showing calming nature scenes or receive standard care. Researchers will measure their mood before and after the proce…

This study tests a program that combines doctor care, digital tools, virtual reality, and school-based support to help teens and adults in Morocco with depression and anxiety. About 146 participants will be split into two groups: one gets the new program, the other gets usual car…

This study tests whether a short, personalized music listening session with a therapist can lower anxiety, stress, and pain in cancer patients starting radiation therapy. 72 adults will be randomly assigned to receive music therapy during their first radiation session or standard…

This study tests whether a short, intensive psychological program before lung cancer surgery can lower anxiety and depression. About 138 adults scheduled for lung cancer surgery will be split into three groups: one receiving four weekly therapy sessions, one refusing support, and…

This study tests a guided self-help CBT manual called 'Khushi or Khatoon' for cancer patients with anxiety and depression. The manual uses culturally adapted stories and exercises over eight weeks. Researchers will enroll 108 adults in Pakistan to see if the manual is feasible, a…

This study tests whether a version of dialectical behavior therapy (DBT) that has been adapted to fit local cultures can help adults aged 18-45 with borderline personality disorder better manage their emotions and reduce self-harm. The therapy is being studied in a low- and middl…

This study looks at whether doing a quick relaxation exercise and applying a cold pack before removing a chest tube can help reduce pain and anxiety and increase satisfaction. About 87 adults who had open-heart surgery and need a chest tube removed will take part. The goal is to …

This pilot study will test whether a program called Facing Your Fears can help reduce anxiety in 24 children aged 12-18 who have both autism spectrum disorder and intellectual disability. The program uses cognitive behavioral therapy techniques like gradual exposure to feared sit…

This pilot study tests whether a dietary supplement made from Leonurus cardiaca (motherwort) can reduce anxiety in adults with Generalized Anxiety Disorder. Sixty participants aged 20-50 will take either the supplement or a placebo for 30 days. Researchers will measure changes in…

This study tests whether structured group therapy, including cognitive behavioral therapy and mindfulness, can reduce symptoms of depression and anxiety in adults in Pakistan. About 108 participants will attend 12 weekly group sessions. The goal is to see if this approach improve…

This study tests whether a culturally adapted self-help workbook based on cognitive behavioral therapy (CBT) can help people with obsessive-compulsive disorder (OCD) in Pakistan. 108 adults with OCD will use the manual over ten weeks, with guidance from a therapist. Researchers w…

This study will test if using an AI chatbot like ChatGPT can help people with generalized anxiety disorder or major depressive disorder who are already in regular therapy. Researchers plan to recruit 204 adults in the U.S. who are currently in individual therapy. Participants wil…

This study tests a one-week course of brain stimulation (called iTBS) for veterans who have both PTSD and chronic pain. Thirty veterans will receive 5-6 short sessions each day for five days, with no placebo group. Researchers will track changes in PTSD symptoms, pain, mood, and …

This study tests whether a gentle, non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve sleep and reduce anxiety in adults over 60 who have chronic insomnia. Sixty participants will receive tACS sessions, and researchers …

This pilot study will test a new type of talk therapy called ACT-SHARE for veterans who have both PTSD and alcohol problems and are struggling with conflict in their romantic relationships. The therapy aims to help veterans manage difficult thoughts and feelings and take actions …

This study looks at whether teaching mindfulness skills to pregnant women admitted to the hospital for risk of preterm delivery can reduce their depression, anxiety, and stress. Researchers will enroll 60 mothers and provide four weeks of mindfulness training. Participants will f…

This study will test a program called Living Well, which includes a mobile app with 21 mental health modules and personal coaching sessions, for breast cancer patients with moderate to severe anxiety. The goal is to see if the program can lower anxiety and reduce overall healthca…

This study tests whether listening to classical music during a hospital stay can lower distress and pain in people with suspected or confirmed lung cancer who are having minimally invasive lung surgery. Half of the 74 participants will receive the music therapy, while the other h…

This study tests a brain-training method called neurofeedback to see if it can help people with obsessive-compulsive disorder (OCD) and post-traumatic stress symptoms feel better overall. Twenty adults on a therapy waitlist will try the training, and researchers will check for ch…

This study looks at whether spending time with a trained facility dog can help children ages 8 to 17 feel less afraid and anxious while staying in the hospital. Participants will either visit with a dog and a child life specialist, do a mindfulness activity, or color. Their heart…

This study will test a mobile app designed to help veterans who have both PTSD and depression. The app teaches skills to manage emotions and relationships, based on a proven talk therapy. Forty veterans will use the app and answer surveys to see if it improves their daily functio…

This pilot study will test whether a weighted blanket can help reduce anxiety and pain in people recovering from total knee replacement surgery. Thirty adults scheduled for knee replacement at NYU Langone will be randomly assigned to receive either a weighted blanket or a regular…

This study tests whether using a mobile app called the Safe and Sound Protocol (SSP) can help adults who are in treatment for substance use and have a history of trauma. About 100 participants will either use the active SSP or a sham version for up to 5 hours over a week, alongsi…

This study tests whether virtual reality (VR) can help people cope with trauma from COVID-19. It involves 100 adults, including healthcare workers and COVID-19 survivors, who will try VR exposure therapy in 5 weekly sessions. The goal is to see if this approach reduces PTSD sympt…

This study tests whether a digital monitoring device called Dalia can improve depression symptoms when added to usual care. About 644 adults with moderate-to-severe depression will use the device for 3 months. The main goal is to see if more people feel significantly better compa…

This study tests whether taking probiotics can improve quality of life, daily activities, and anxiety in people who have had a moderate stroke. Researchers will enroll 110 adults aged 18 to 80 who had a stroke within the past 3 months. Participants will take probiotics and be mon…

This study tests a therapy called CFTSI for children aged 7 to 17 who have experienced a traumatic event in the last 3 months. The goal is to see if CFTSI reduces post-traumatic stress symptoms better than standard supportive therapy. 140 children and their families will take par…

This study combines virtual reality with a gentle electrical pulse on the ear (called taVNS) to help people with chronic shoulder pain who are waiting for surgery. The goal is to see if this drug-free approach can reduce pain, anxiety, and depression. Only 10 people will take par…

This study tests whether a therapy called Sensory Motor Arousal Regulation Treatment (SMART) works better than standard care for youth aged 7-17 who have experienced trauma and struggle with self-regulation. The trial will involve 120 participants randomly assigned to SMART or us…

This study tests if watching a virtual reality (VR) video of an MRI scan before the real thing can help children aged 5 to 10 stay calm and still. About 150 kids having their first MRI will be split into three groups: one watches the VR video at home and again at the hospital, on…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works in people. Participants will be monitored for safety and any effects. The study is still ongoing, and details about who can join are not yet …

This study looks at brain activity in teenagers aged 10 to 17 with ADHD, OCD, or no diagnosis. Researchers will use EEG, MRI, and MEG to measure brain signals while participants do computer tasks. The goal is to understand how the brain controls thinking and behavior, which may h…

This study looks for brain-based markers (biomarkers) of obsessive-compulsive disorder (OCD) in people with severe, hard-to-treat symptoms. Participants complete decision-making tasks and are exposed to personal OCD triggers while their brain activity is recorded with EEG and the…

This study tests a new program called CapExchange, where people with stable mental health conditions exchange practical skills with others in their community. The goal is to see if this approach is practical and helpful for improving well-being and social connection. About 10 to …

This study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…

This study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…

This study will implant deep brain stimulation devices in 10 adults with severe, treatment-resistant OCD to record brain activity during approach and avoidance tasks. Researchers will compare clinic-based and at-home recordings to find neural markers of OCD symptoms. The goal is …

This study will follow 45,000 university students over three years to understand how financial struggles, housing issues, and loneliness affect their mental health and whether they seek help. Participants will fill out questionnaires about their well-being and life circumstances.…

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

This study looks at moral injury—a type of distress that happens when workers cannot act according to their values—among healthcare professionals in psychiatric facilities in the PACA region of France. Researchers will survey about 2,688 workers to understand what causes this suf…

This pilot study will examine whether certain genes related to serotonin are linked to gut bacteria that process tryptophan in adults with depression, anxiety, PTSD, or panic disorder. Thirty participants will provide saliva and stool samples from home. The goal is to gather info…

This study looks at brain activity recorded from deep brain stimulation (DBS) devices in 20 people with Parkinson's disease. Researchers want to see if certain brain signals are linked to symptoms like sudden anxiety, impulse control problems, and hallucinations. Participants wil…

This study works with 40 veterans who have PTSD to understand why many don't start recommended therapies like CPT or PE. Researchers will look at the treatments veterans try first and how that affects their next steps. The goal is to create a program that helps veterans get the r…

This study will use wearable devices like heart rate monitors and sleep trackers to see how financial stress and news affect your body. Researchers will follow 2,500 adults remotely, collecting data on heart rate, sleep, and stress levels. The goal is to create AI tools that can …

This study tests whether a wrist-worn biosensor can detect changes in the body's stress response during ketamine-assisted therapy for PTSD. Five adults will wear the device before, during, and after therapy sessions. The goal is to see if a specific pattern of nervous system acti…

This study looks at whether a new strategy to detect and refer pregnant and postpartum women with depression or anxiety to mental health services works well in routine care. About 3000 women will take part. The goal is to see if early help is feasible and acceptable, and to test …

This study looks at whether a type of brain stimulation called transcranial magnetic stimulation can help people with OCD shift their behavior more flexibly. It involves 12 participants who will receive three daily sessions of stimulation. The goal is to see if the procedures are…

This study follows 75 volunteer first responders who are alerted via a smartphone app to help in out-of-hospital cardiac arrests. Researchers want to understand how these stressful events affect the volunteers' mental health and whether a structured follow-up conversation can hel…

This study will test a customized online health program for Canadian women Veterans and their families. The program includes health missions, peer support, and social connection to encourage physical activity and healthy habits. Researchers will track how many people complete the…

This study aims to develop and pilot a program for people with HIV in South Africa who also face depression, trauma, and food insecurity. Researchers will first explore how these problems interact, then create a treatment called CBT-SA that combines therapy, nutrition support, an…

This study aims to adapt a digital mental health app called Wysa for adolescent girls aged 13-18 in rural Uttar Pradesh, India, who have anxiety or depression. Researchers will work with the girls, their families, and community members to identify what helps or hinders app use an…

This study tests a web-based toolkit that helps healthcare providers screen for intimate partner violence and mental health issues in patients receiving treatment for opioid use disorder. About 792 patients and their providers will use the toolkit during routine care to see if it…

This study will enroll 500 adults with high levels of repetitive negative thinking (like worry or rumination) to understand why cognitive-behavioral therapy helps. Participants will receive one of two digital therapy programs: one focusing on concrete thinking, the other on self-…

This study examines how 180 adolescents aged 14-18 with trauma-related symptoms react to stress and strong emotions. Researchers will measure brain activity, heart rate, and anxiety while teens repeatedly imagine details of their own traumatic event. The goal is to understand whi…

This study looks at how people with anxiety make decisions to avoid things that make them anxious. Researchers will use brain scans and phone tracking to see how avoidance behavior works in the lab and in real life. About 163 adults with and without anxiety will take part. The go…

This study looks at how low levels of carbon monoxide (CO) from smoking or the environment affect pain, senses, anxiety, and depression. Researchers will measure CO in the breath of 70 healthy adults and test their pain threshold and mood. The goal is to better understand CO's su…

This study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …

This observational study will survey over 300 Ukrainian women to understand how war influences their decisions about pregnancy and childbirth, and their mental health during the perinatal period. Participants will complete questionnaires about their well-being, reproductive choic…

This study looks at whether giving both food assistance and psychological counseling helps young adults aged 18-25 who face food insecurity and mental health issues. Participants will receive weekly food aid for a year, and half will also get twice-monthly therapy for six months.…

This study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can change how people remember the order of emotional movie clips. Researchers will compare active TBS to a sham (fake) version in 120 healthy adults. The goal is to understan…

This study will test a non-invasive brain stimulation method called temporal interference (TI) in 300 healthy volunteers and people with anxiety or PTSD. TI uses two weak electrical fields to target deep brain areas linked to fear and emotion without affecting the surface of the …

This study is testing whether functional MRI brain scans can predict and track how well children and teens with obsessive-compulsive disorder (OCD) respond to a type of therapy called Exposure and Response Prevention (ERP). Thirty participants aged 10 to 17 will receive 14 weekly…

This study looks at whether an 8-week CrossFit program can make kids aged 7 to 11 stronger, fitter, and happier. Thirty children will be split into two groups: one does CrossFit twice a week, the other continues their normal routine. Researchers will measure physical changes like…

This study compares 200 people with alcohol use disorder to healthy volunteers using questionnaires that measure psychological processes and emotional symptoms like depression and anxiety. The goal is to identify differences in how people think and cope. It is purely observationa…

This study is testing a new online program called Whole Selves, designed specifically for transgender and nonbinary young adults. The program helps them think about their alcohol use and romantic relationships in a way that fits their experiences. About 107 people will try the pr…

This study tests a nursing program that uses motivational interviewing to help rural women feel less afraid of cervical cancer and more willing to get screened. Eighty women aged 30-65 will take part in four weekly one-on-one sessions. Researchers will measure changes in their he…

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change before treatment and at 3, 6, and 12 months after. Researchers will use questionnaires to track these changes. The goal is to better understand recovery …

This study looks at how emotional state influences the course of functional dyspepsia and irritable bowel syndrome in 150 adults. Participants will fill out questionnaires about their quality of life, mood, and anxiety at the start and after treatment. The goal is to better under…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study looks at how anxiety and depression influence shared decision-making in patients aged 65 and older with critical limb threatening ischaemia (CLTI), a severe form of leg artery disease. Researchers will interview patients, their carers, and healthcare staff to understan…

This observational study will follow 250 adults treated in the emergency department for major trauma. Researchers want to see if early factors like thinking flexibility, social support, and stress levels can predict who develops PTSD within 6 months. Participants fill out questio…

This study looks at whether a video-supported flipped learning model can lower anxiety and improve skill levels in midwifery students learning episiotomy. About 60 third-year midwifery students will be split into two groups: one gets traditional classroom teaching, the other watc…

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This study asks children aged 6-16, their parents, and clinicians to vote on the most important research topics in pediatric anesthesia and perioperative medicine. Over 1,000 participants in Switzerland will complete online surveys to create a ranked list of the top 10 priorities…

This observational study looks at 85 adults with Bell's palsy to see if worse facial muscle function is linked to higher anxiety, depression, and lower self-esteem. Researchers will measure facial movement and muscle activity, then compare those results with participants' answers…

This observational study will look at 138 adults with hemophilia and joint damage to understand how central pain mechanisms and psychological factors like anxiety affect pain interference in daily activities. Researchers will measure pain intensity, sleep quality, and pain self-e…

This study follows 300 Ukrainian veterans who lost a limb in combat to see if longer evacuation times or extended tourniquet use increase the risk of developing PTSD. Participants will be monitored for 18 months using PTSD symptom questionnaires. The goal is to identify factors t…

This study tests a short media campaign (about 3-5 minutes) designed to encourage parents and caregivers in Nigeria to vaccinate their children. The campaign aims to reduce vaccine hesitancy, address fears, and improve vaccine access. About 74 participants whose children are not …

This study will survey 160 adults on long-term hemodialysis at Sohag University Hospital to find out how many experience anxiety or depression. Researchers will also look for links to age, gender, and other health factors. The goal is to better understand the mental health needs …

This study will follow 120 adults receiving a steroid injection for lower back and leg pain caused by a slipped disc. Researchers want to see how factors like anxiety, pain during the procedure, and sedation affect how satisfied patients feel one hour after the injection. The goa…

This study tests whether giving mothers online training about introducing solid foods helps their babies grow and develop better. 132 mothers and their 5-month-old babies will take part. The training covers feeding behaviors, and researchers will measure baby growth, development,…

This study looks at how certain brain circuits cause strange sensory feelings in people with Obsessive-Compulsive Disorder (OCD). It will test if a non-invasive brain stimulation technique called rTMS can reduce these symptoms. The study involves 120 adults with OCD and healthy v…

This study will observe 300 people with long-term jaw and face muscle pain (TMD) to see how psychological factors relate to their physical symptoms. Participants will fill out questionnaires about their pain and other body symptoms. The goal is to better understand the role of me…

This study follows 150 adults with severe arm or leg injuries that required a tourniquet to stop bleeding. Researchers will track how long the tourniquet was used and check for pain, nerve damage, and recovery over 6 months. The goal is to see if longer tourniquet use increases t…

This study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…

This study looks for biological markers in tumor tissue and blood that may be linked to anxiety and depression in people with solid tumors. Researchers will combine psychological assessments with lab tests to better understand these emotional struggles. The goal is to improve ear…

This study looks back at data from 80 veterans and first responders who completed a 12-week program that combined mental health support, physical therapy, nutrition advice, and occupational therapy. Researchers want to see if the program helped improve sleep, anxiety, depression,…

This early-stage study looks at how the drug buagafuran (AF-5) behaves in people with liver impairment compared to those with normal liver function. Twenty-four adults will receive a single 30 mg dose, and researchers will measure drug levels in the blood and monitor safety. The …

This study looks at how fear of movement (kinesiophobia) affects daily function in people with rheumatoid arthritis. Researchers will compare 200 RA patients with 200 healthy volunteers to understand links between fear, pain, fatigue, mood, and muscle loss. The goal is to find no…

This study tests whether a short educational video, shown alongside standard information, can help first-time heart attack patients better understand their upcoming heart catheterization and feel less anxious. About 140 participants will be randomly assigned to receive either sta…

This study looks at how nomophobia (fear of being without a phone) affects anxiety and academic confidence in university students who have text neck (neck pain from looking down at phones). Researchers will survey 396 students aged 18-35 who use smartphones at least 3 hours daily…

This study looks at how trauma exposure relates to suicidal thoughts and behaviors in teenagers aged 11 to 17 who are in psychiatric hospitals. Researchers will compare teens admitted for suicide attempts with those admitted for other reasons. They will use questionnaires and blo…

This study is creating a decision-support tool called CRAFTT to help therapists tailor mental health treatments to the cultural values and experiences of Latine youth (ages 5-15). The goal is to improve how well these treatments work and reduce mental health disparities. Research…

This study uses a non-invasive brain stimulation technique called TMS to temporarily change activity in a brain region linked to anxiety. Researchers will use fMRI scans to see how this affects brain connections and anxiety-related startle responses. 140 adults with anxiety will …

This study looks at how two types of noninvasive brain stimulation affect brain activity and the body's stress system in people with both PTSD and major depression. Fifty adults will receive both active and sham stimulation in random order, with brain and heart measurements taken…

This study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…

This study will compare obsessive-compulsive symptoms in 102 adults with substance use disorder to a similar group without it. Participants will complete interviews and questionnaires to measure OCD severity, addiction severity, and quality of life. The goal is to understand how …

This study looks at how a brief writing therapy called Written Exposure Therapy (WET) works for people with both PTSD and substance use disorders who are in residential treatment. About 108 participants will either do WET or neutral writing alongside their usual care. Researchers…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study interviews 30 adults with generalized anxiety, social anxiety, or PTSD who previously completed a trial comparing two therapies: metacognitive therapy (MCT) and cognitive-behavioral therapy (CBT). The goal is to learn what participants thought about each treatment to h…

This study tests whether a smartphone app, co-created with teens, plus trained peer navigators can help more young people ages 13-22 get mental health care in schools and clinics. Over 8,000 youth will take part across multiple sites. The goal is to see if this approach increases…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…

This study will survey 400 adults visiting a urology clinic for the first time. Researchers want to learn if patients who use AI chat tools (like ChatGPT) before their appointment feel more or less anxious, satisfied, and informed compared to those who don't. Participants fill ou…

This study looks at how menopause changes the way the body processes escitalopram, a common antidepressant. Researchers will measure drug levels in the blood of 94 women aged 40-60 who are premenopausal or menopausal and taking the medication for depression or anxiety. The goal i…

This study looks at 300 adults with bronchiectasis, a chronic lung condition, to understand why many also experience anxiety and depression. Researchers will collect blood, sputum, and stool samples to analyze metabolic pathways and identify biomarkers. The goal is to find clues …

This study checks if an AI software can accurately measure depression and anxiety symptoms in 650 adults. Participants will have their symptoms rated by both the AI and human experts to see if the AI works well across different groups. The study does not provide any treatment—it …

This study will test a digital tool called AI-COA® to see how well it measures the severity of depression and anxiety compared to standard clinician ratings. About 150 adults in the U.S. who are starting a new treatment for depression or anxiety will use the tool over 12 weeks. T…

This study will ask 380 heart patients and healthcare workers at Assiut University Heart Hospital to fill out questionnaires about depression, anxiety, stress, and burnout. No treatments or changes are given—the goal is simply to find out how common these mental health problems a…

This pilot study tests a 3-5 minute recorded message called PEACE, designed to improve mental wellbeing and public attitudes toward reintegrating former Boko Haram members in Nigeria. Researchers will enroll 74 adults to see if the intervention is acceptable and feasible. The goa…

This study will give 40 adults with major depression and moderate-to-severe anxiety a single dose of CYB003 (a synthetic version of psilocin, the active ingredient in magic mushrooms) or a placebo. Researchers will use brain scans (fMRI, EEG) and questionnaires to see how the dru…

This study will test whether an AI-generated educational program can improve how mothers manage their children's fevers and reduce their anxiety. Eighty mothers of young children visiting a Turkish emergency department will be split into two groups: one gets the AI-based training…