Anxiety disorder

This trial tests whether two types of talk therapy, Acceptance and Commitment Therapy (ACT) and Cognitive Behavioral Therapy (CBT), can ease depression and related issues better than usual care in people who have major depression and are facing marital crisis. About 120 adults wi…

Researchers at UC San Diego are testing whether a computer-based working memory training session, done right before a brief exposure exercise, can improve fear extinction learning in adults with social anxiety disorder. Participants will be randomly assigned to either the working…

This study tests whether a 12-week program of supervised exercise, Mediterranean diet education, and stress management workshops can improve health in 120 overweight or obese adults. Participants will wear a smart bracelet to track activity and sleep. Researchers will measure cha…

This study asks whether tapering and stopping certain psychotropic medications before intensive trauma-focused psychotherapy helps people with PTSD more than continuing those medications during therapy. Researchers will compare patients treated under a new medication-review polic…

Researchers are testing whether a personalized form of brain stimulation can ease symptoms in people with anxiety disorders that have not improved with standard treatments. The approach uses a device to deliver rapid magnetic pulses to specific brain circuits, guided by each pers…

This trial tests whether transcranial magnetic stimulation (TMS) can engage the amygdala—the brain's fear center—in adults with post-traumatic stress disorder (PTSD). Participants receive either active or sham TMS every weekday for six weeks, guided by MRI to target a personalize…

This trial tests whether propranolol, a blood pressure drug, can reduce PTSD symptoms in women who have experienced severe violence. Participants take propranolol and then revisit their traumatic memories in a structured session with a psychologist. The study compares this approa…

This trial is testing the long-term safety and tolerability of an investigational drug called SEP-363856 (ulotaront) in adults with generalized anxiety disorder (GAD). Participants who completed a previous phase 3 study will take the drug daily for 26 weeks. The study will monito…

This trial tests whether pregnenolone, a natural hormone, can help adults with both alcohol use disorder and major depression. Participants take either pregnenolone or a placebo for 12 weeks, while researchers track drinking, cravings, and mood. Brain scans will also look at how …

This phase 2 trial is testing whether a one-day treatment combining repetitive transcranial magnetic stimulation (rTMS) with the drug D-cycloserine can help military personnel and veterans with PTSD. The study will enroll 50 participants who will receive either the active treatme…

This study is testing a new approach for young adults (ages 18-26) with posttraumatic stress disorder (PTSD) who have experienced childhood trauma. The treatment combines the substance MDMA with talk therapy sessions, known as MDMA-assisted therapy. The main goals are to see if t…

This phase 2 trial is testing whether a single day of repetitive transcranial magnetic stimulation (rTMS), combined with a dose of D-cycloserine, can help first responders with post-traumatic stress disorder (PTSD). About 50 participants will receive either the active treatment o…

This trial tests whether combining eye movements with different ways of reactivating a memory can reduce the frequency and distress of intrusive trauma memories in people with PTSD. Participants are randomly assigned to one of three procedures: unconscious trauma reactivation, ac…

This trial is testing whether a personalized form of brain stimulation, called accelerated intermittent theta-burst stimulation (iTBS), can improve symptoms of depression and anxiety in people with treatment-resistant depression. The approach uses brain imaging to target specific…

This study tests whether a short couples therapy, called MERA-C, can help reduce intimate partner violence and improve emotional health in veteran couples. The therapy involves four weekly sessions with both partners, focusing on managing emotions to prevent aggression. Researche…

This trial explores whether personalized brain imaging can predict who responds best to three rapid-acting treatments for suicidal ideation in people with depression or PTSD. Participants receive either real-time brain feedback (neurofeedback), a form of magnetic brain stimulatio…

This study tests a harm reduction approach for people who use anabolic-androgenic steroids (AAS) without a prescription. Participants will receive four counseling sessions to help them reduce their steroid use and improve their health. The trial will measure changes in steroid us…

This study tests whether MDMA, combined with a type of talk therapy called Acceptance and Commitment Therapy (ACT), can help treat post-traumatic stress disorder (PTSD) in military service members. Participants receive either a full or low dose of MDMA during therapy sessions. Th…

This study explores whether a non-invasive device that stimulates the vagus nerve through the ear can help people with PTSD learn to dampen fear responses. Participants will receive either active or sham stimulation while their body reactions (heart rate, sweat, startle) are meas…

This pilot study tests a behavioral program called CBITS-RTM, adapted for teens in juvenile detention. The program combines group and individual therapy to address post-traumatic stress and includes a module on racial trauma. Researchers want to see if it reduces PTSD symptoms an…

This study tests a program called NPOWER365 for Black men who have sex with men and are living with HIV. The program uses a smartphone app, online forums, and resource referrals to help with medication adherence, mental health, and access to care. About 350 participants in the At…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests a non-invasive procedure that uses sound waves to target a small area in the brain thought to be involved in obsessive-compulsive disorder (OCD). It is for adults aged 25-64 with moderate to severe OCD that has not improved with standard treatments like therapy a…

This study tests a program called THRIVE for teen mothers in Barbados who are feeling stressed or down. The program includes seven sessions on sexual health, parenting, and life skills to improve mental health and prevent another unplanned pregnancy. Researchers will compare the …

This study explores whether artificial intelligence can help emergency department doctors identify depression and anxiety in patients. Researchers will record 30 adult patients' facial expressions and voice tones as they read a story, and then use AI to analyze those recordings. …

This study will test if a smartphone app that analyzes speech can accurately screen for depression and anxiety in university students. Researchers will enroll 80 students aged 16 to 25 and compare the app's results with standard questionnaires. The goal is to see if voice pattern…

Researchers at a state hospital in Turkey are testing whether training an entire maternity unit in trauma-informed care changes the experience of childbirth. The program teaches hospital leaders, midwives, nurses, doctors, and support staff to communicate respectfully, protect wo…

This pilot trial tests a two-hour educational workshop called SCREEN, designed to raise awareness of prostate cancer, its symptoms, and the benefits of early screening. The study enrolls men aged 18 to 79 who are not up to date with their prostate cancer screening. Researchers wi…

Researchers are testing a 10-session bilingual therapy program called PrEPared Minds/Mentes PrEParadas. The program uses cognitive behavioral therapy to reduce anxiety and depression in men who have sex with men. The goal is to see if improving mental health helps these men learn…

This trial tests whether an online parenting program, Partners in Parenting, can reduce the risk of depression and anxiety in adolescents aged 12 to 18. Researchers will adapt the program for families in Pakistan and compare it to a teen-focused program and a control group. The s…

This pilot trial tests a program called EA$E-US for couples who fled the Democratic Republic of Congo and now live in the U.S. The 8-session curriculum teaches communication, conflict resolution, joint decision-making, and coping skills. Researchers want to see if it can reduce i…

This study tests a short, 4-session therapy for burn survivors and their caregivers to prevent posttraumatic stress disorder (PTSD). The therapy, called Promotion of Emotional Disclosure for Burns (PoED-B), helps patients and their loved ones communicate better about the traumati…

This study tests a new media-based program called CONSCIOUS to help men in Nigeria recognize symptoms of mental health issues like anxiety and suicide risk, and encourage them to seek support. The program uses videos or other media to reduce stigma and improve help-seeking. 74 me…

This study tests whether a 4-hour resilience workshop can prevent PTSD and depression in 800 first responders in New York and Texas. Participants will be randomly assigned to the workshop or a control group and followed for one year. The goal is to see if the training helps them …

This study tests whether an AI-informed peer-mentoring program can help healthy teens and young adults (ages 12-25) manage stress and build social skills, lowering their risk of developing anxiety or depression. Researchers will compare this program to standard mentoring and heal…

This study tests whether digital exercises on a smartphone can help teens aged 16-19 avoid relapse of depression or anxiety. Participants who have recovered from a past episode will use a research app to work through thoughts and feelings while they feel well. Some will join onli…

This study tests whether the blood pressure medication propranolol can prevent post-traumatic stress disorder (PTSD) in women who have experienced sexual violence. 34 women will receive either propranolol or a placebo within 72 hours of the assault, then take it for about three w…

Children scheduled for angiography often feel anxious, which can affect their heart rate, blood pressure and cooperation during the procedure. This trial tests whether a short virtual reality guided breathing exercise, delivered through a headset showing calming scenery, can redu…

People hospitalized after a traumatic injury often face post-traumatic stress, depression, and substance use problems. This study tests a program called Trauma Resilience and Recovery Program Portal 2.0, which adds bedside screening, education, text-message check-ins, and follow-…

Researchers are testing whether brexanolone, an intravenous drug approved for postpartum depression, can reduce PTSD symptoms and stress-related drinking in veterans who have both PTSD and alcohol use disorder. The study enrolls 40 veterans aged 21 to 70. Participants receive one…

People with Parkinson's disease often struggle with balance and anxiety, and the two can make each other worse, especially when they try to walk and think at the same time. High-intensity aerobic exercise may help both, but Parkinson's symptoms make it hard for many to reach that…

This study tests whether a supplement called FibroThol (containing 2-Aticyto Complex and D-ribose) can help reduce pain and other symptoms in people with fibromyalgia. About 200 adults aged 18 to 65 who have had fibromyalgia for at least a year and are already on standard medicat…

Researchers are studying whether a broad-spectrum oral tincture containing CBD, CBN, and CBG changes anxiety symptoms in adults with generalized anxiety disorder. About 60 participants will take the tincture under the tongue or by mouth roughly every 12 hours for 8 weeks, with fo…

Researchers at the University of Bergen are testing whether a two-week, self-guided smartphone screen time reduction program can reduce depression symptoms in young adults. The trial enrolls 200 students in Oslo who have sought help at the student mental health service. Participa…

This pilot trial tests whether adding virtual pain neuroscience education to standard spinal cord stimulation can help chronic pain patients better manage their condition. The education teaches how the brain processes pain, aiming to reduce fear, anxiety, and catastrophizing. Par…

This study tests an online self-help tool called e-couch for adults with social anxiety. Over 5 weeks, 200 participants will use the program, which is based on cognitive behavioral therapy. Researchers will use surveys and computer tasks to predict who improves the most.

This trial tests whether a traditional Chinese music therapy, called Ziwu Liuzhu Five-Element Music Therapy, can reduce anxiety in people with pancreatic cancer who are undergoing chemotherapy. The study will enroll 320 patients with mild-to-moderate anxiety and randomly assign t…

This study looks at whether drawing different colors and shapes can help calm adults who are anxious while waiting for surgery. About 175 people scheduled for elective surgery will participate. Researchers will measure their anxiety levels before and after the drawing activity to…

Researchers at the Medical University of South Carolina are testing a program that adds community health workers to standard trauma recovery services. The study enrolls 100 adult trauma patients who screen positive for PTSD or depression risk and report at least one unmet social …

This trial compares a specially designed needle tip, the Transcodent painless needle, with a standard dental needle to see if it causes less pain during injections in the upper front teeth area. Sixty adults needing dental work on both sides of their mouth will receive injections…

This study tests whether a mobile app that combines digital cognitive behavioral therapy (CBT) with personal mental health coaching can reduce anxiety in adults with hearing or mobility disabilities. Participants use either the active program or a sham version for 8 weeks, with f…

This study tests whether a single session of low-intensity focused ultrasound (LIFU) can safely reduce chronic pain and anxiety symptoms. Ten adults with either generalized anxiety disorder or chronic pain will receive multiple ultrasound pulses in one visit and be followed for s…

Researchers are testing whether a group-based acceptance and commitment therapy (ACT) program can improve the psychological well-being and quality of life of parents of children with cerebral palsy. The trial enrolls 76 parents who attend eight weekly 90-minute group sessions led…

Researchers at Massachusetts General Hospital are testing whether a wearable patch can help autistic teenagers manage anxiety. The patch senses heart rate and guides paced breathing through a phone app, offering practice sessions and prompts during stressful moments. The trial en…

This study looks at whether combining group cardiovascular exercise with group therapy can help reduce symptoms of anxiety and depression in adults living in rural areas. Twenty participants with generalized anxiety or depressive disorders will take part in a structured program. …

Researchers are testing whether a five-minute box breathing exercise can reduce pain, anxiety, and breathlessness when a chest tube is removed after open-heart surgery. The trial enrolls 86 adults who have just had heart surgery and still have a chest tube. Half perform 15 cycles…

Researchers are testing a smartphone app called FobiApp that uses augmented reality to guide people through exposure therapy for cockroach phobia. Adults with a diagnosed cockroach phobia use the app at home, working through increasingly difficult levels that show virtual cockroa…

This clinical trial is testing a non-invasive brain stimulation method called temporal interference transcranial alternating current stimulation (TI-tACS) for people with major depressive disorder or generalized anxiety disorder. The device uses two high-frequency electrical curr…

Researchers test whether transcutaneous electrical acupoint stimulation, a non-invasive way to stimulate acupuncture points, adds benefit to exposure and response prevention therapy for adults with obsessive-compulsive disorder. The trial enrolls 90 people aged 18 to 50 with mode…

Researchers test whether spending 10 minutes with a trained Judicial Assistance Dog in the waiting room lowers anxiety in child victims of abuse before a forensic interview. The trial enrolls 46 children aged 7 and older who are visiting a child advocacy and pediatric assessment …

Researchers at Peking University are studying a 49-day digital mindfulness program for adults with emotional distress, depression, or anxiety. About 100 participants use a mobile app that delivers daily guided meditations, short lessons on emotions, and practical exercises. The t…

Researchers at Beijing Normal University are testing whether a guided nature photography program can ease mild depression and anxiety in young adults. Around 300 participants with mild emotional distress will be randomly assigned to take nature photos, take photos of human-made o…

This trial tests two sedatives—remimazolam and dexmedetomidine—to see which better relieves anxiety while keeping pregnant women comfortable and safe during spinal anesthesia placement for scheduled C-sections. The study includes 150 women at full term and measures success by pat…

Researchers are testing whether squeezing a stress ball during femoral arterial sheath removal after coronary angiography can reduce pain and anxiety and improve patient satisfaction. The trial enrolls 34 adults who had a stent or balloon angioplasty through the femoral artery. H…

This trial tests whether progressive muscle relaxation, a technique where you tense and then relax different muscle groups, can lower anxiety in parents who are the primary caregivers of children with cancer. Researchers will randomly assign 112 parents to either join relaxation …

This trial tests whether brief, video-guided jaw relaxation or breathing exercises can reduce anxiety and fear in children aged 4 to 10 who are having burn dressings changed. Children in a pediatric burn unit will be randomly assigned to one of three groups: jaw relaxation, breat…

This study tests whether a single dose of psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce PTSD symptoms in adults who have survived intimate partner violence. 76 participants will receive either a high or low dose and complete weekly th…

This trial tests whether a mobile-guided mindfulness breathing program can reduce symptom distress, fatigue, anxiety, and depression in adults with cancer receiving chemotherapy. Eighty participants will be randomly assigned to either practice 5 to 10 minutes of guided breathing …

This trial tests whether six sessions of receptive music therapy, using a specific method called Kigonki, can reduce anxiety in people with advanced cancer who are hospitalized in palliative care units. Participants will be randomly assigned to receive the music therapy or to hav…

This trial tests whether an AI-powered support tool, accessed through a WeChat Mini Program, can reduce anxiety in men recently diagnosed with metastatic prostate cancer. Participants are randomly assigned to use the platform with the AI agent or without it for the first two week…

This trial tests whether a structured, one-on-one educational session led by a nurse before an endoscopic retrograde cholangiopancreatography (ERCP) can reduce patient anxiety and improve knowledge about the procedure. Sixty adults scheduled for elective ERCP will be randomly ass…

This trial tests whether wearing virtual reality glasses during double J stent removal can lower patient anxiety and pain. The procedure, common after kidney stone surgery, often causes distress. Researchers will compare patients who use VR distraction with those receiving standa…

This trial tests whether using a weighted blanket during a hospital stay can reduce pain and anxiety in adults recovering from traumatic injuries. Half of the 50 participants will receive a weighted blanket, while the other half gets a standard hospital blanket. Researchers will …

This trial tests whether different electroacupuncture frequencies can ease symptoms of generalized anxiety disorder, a condition marked by persistent, excessive worry. Researchers will compare three stimulation patterns (2 Hz, 100 Hz, and a mixed 2/100 Hz wave) against a sham ver…

Researchers are testing whether a dexmedetomidine nasal spray can reduce anxiety in patients scheduled for brain tumor surgery. Participants receive the spray the night before and the morning of surgery, and their anxiety levels are measured before and after the procedure. The tr…

This trial tests whether an 8-day mindfulness body scan can reduce stress, anxiety, and depression in adults who survived tidal flooding in Sayung, Demak, Indonesia. Participants will practice guided body scan meditation and have their blood tested for inflammation markers before…

This trial tests whether an 8-day mindfulness body scan can reduce stress and inflammation in people who have survived repeated tidal flooding. Researchers will measure blood markers like IL-6, TNF-α, CRP, and cortisol, along with questionnaires on depression, anxiety, sleep, and…

This trial tests whether combining laughter yoga with virtual reality nature scenes can reduce anxiety and improve sleep in people who are in the early stages of chemotherapy. Participants will either receive this digital behavioral intervention during their chemotherapy infusion…

This study tests whether adding a support person to a trauma-informed cognitive training program helps people with post-traumatic stress improve their daily functioning and reduce distress. The program, called TIGMT, teaches skills like attention, planning, and problem-solving, a…

This study tests a self-help program for 200 post-9/11 veterans who have depression or PTSD symptoms but are not in therapy. The program teaches healthy coping skills and how to find support services. Researchers will compare the self-help group to those receiving standard resour…

This study tests whether a four-week online yoga program, tailored to each teen's physical limits, can lower anxiety in adolescents aged 12 to 18 who are being treated for cancer. Participants either join the yoga sessions or receive no extra intervention, and researchers measure…

This study tests whether a 10-session virtual group psychotherapy program can help people with inflammatory bowel disease (IBD) who also have anxiety or depression. The therapy is adapted from a standard manual called Mind Over Mood and includes education on the brain-gut connect…

This trial tests whether guided imagery, a relaxation technique using audio recordings, can reduce anxiety and improve sleep and comfort in adults with acute coronary syndrome, such as a heart attack, who are in a cardiac intensive care unit. Participants will be randomly assigne…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This pilot study tests whether psilocybin-assisted psychotherapy is feasible, safe, and potentially helpful for military veterans with treatment-resistant posttraumatic stress disorder (PTSD). Twelve veterans will receive two psilocybin sessions (15 mg and 25 mg) within a structu…

This study aims to create a brief behavioral intervention for older adults (60+) with lung cancer, addressing aging-specific concerns like depression, anxiety, pain, and shortness of breath. In the first phase, patients, caregivers, and providers give feedback on the program. In …

This study tests whether structured spiritual care from a chaplain can reduce anxiety and improve well-being for family members of ICU patients who cannot make decisions for themselves. The chaplain will meet with the family surrogate several times and stay in touch weekly. The t…

This study looks at whether adding cannabis to standard talk therapy can help veterans with PTSD feel less anxious, depressed, or suicidal. About 280 veterans who have used cannabis before but not recently will take part. Researchers will track changes in PTSD symptoms, brain act…

This trial tests whether having family members write a digital diary during and after a loved one's ICU stay can help them cope with grief. Forty family members of ICU patients receiving life-sustaining treatment will be randomly assigned to either write a diary via WhatsApp or r…

This study tests an adapted version of a therapy called STAIR-NT, designed to help first responders who have both PTSD and a history of traumatic brain injury. The therapy combines skills training and narrative therapy to address emotional regulation and interpersonal issues. Res…

This trial tests whether coloring mandalas—intricate circular patterns—can help reduce anxiety and improve sleep quality in female students who experience premenstrual syndrome (PMS). Participants will be asked to color mandalas, and researchers will measure changes in their anxi…

This trial tests whether adding mindfulness training to a standard respiratory symptom management program can reduce anxiety and ease breathlessness, cough, and fatigue in people with lung cancer. About 189 patients will be randomly assigned to one of three groups: the combined m…

This trial tests whether a brief therapy called Written Exposure in Substance Treatment (WEST) can reduce PTSD symptoms in people staying at a residential substance use program. Participants with PTSD are randomly assigned to receive WEST plus usual care or usual care alone. The …

This trial tests whether a 10-session online group cognitive-behavioral skills training program can reduce symptoms of depression and anxiety in university students. About 400 students who screen positive for these symptoms will be randomly assigned to either the online CBT progr…

This study tests whether a brief video that familiarizes patients with the operating room environment can reduce postoperative pain and anxiety in men undergoing prostate surgery for benign enlargement. Participants will be randomly assigned to watch the video either the day befo…

This trial tests whether virtual reality (VR) distraction can reduce pain, anxiety, and the need for pain medications during prone pain procedures, compared to standard care alone. About 230 adults undergoing such procedures at a pain clinic will be randomly assigned to either us…

This pilot study tests a culturally adapted empowerment self-defense program for Indigenous women (including American Indian, Alaska Native, and Two Spirit individuals) who have experienced sexual violence and currently have moderate to severe depression or PTSD. The program teac…

This pilot study explores whether surface-guided radiotherapy (SGRT) can help head and neck cancer patients who feel anxious or claustrophobic during standard radiation treatment. Instead of a tight thermoplastic mask, SGRT uses a camera system to track patient position in real t…

This trial tests whether a brief multisensory stimulation session before a pediatric surgery clinic visit can lower anxiety and fear in children aged 5 to 10, as well as reduce parental anxiety. Children undergoing their first surgical evaluation will be randomly assigned to rece…

This trial tests whether listening to alpha-frequency binaural beats—a type of auditory stimulation that may promote relaxation—can reduce pain and anxiety after orthodontic separator placement. Participants aged 15-30 with mild crowding will be randomly assigned to either listen…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study tests whether an 8-week mobile app program, based on Transition Theory, can help first-time expectant fathers reduce anxiety, strengthen their bond with the unborn baby, and improve marital adjustment. About 96 fathers whose partners are 26-28 weeks pregnant will be ra…

This trial tests whether using a virtual reality headset during regional anesthesia can lower patients' anxiety and pain. Adults aged 18 to 64 having elective surgery with regional anesthesia will either receive VR distraction or standard care. Researchers will measure anxiety an…

This trial tests whether giving a combination of dexmedetomidine and esketamine during and after laparoscopic ureteral reconstruction can reduce depressive symptoms and anxiety in patients. The study enrolls 658 adults with ureteral stricture who are scheduled for this surgery. P…

This study tests whether a six-session online program that helps young adults explore meaning in life can reduce symptoms of depression and anxiety. Participants are randomly assigned to either the program or a waitlist. The goal is to see if building a sense of purpose improves …

This study explores whether a short, evidence-based therapy called Written Exposure Therapy (WET) can help pregnant and postpartum women who have PTSD and a history of substance misuse. Participants receive five weekly telehealth sessions where they write about a traumatic experi…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This trial tests whether an AI-based system can provide preoperative counseling for elective cesarean delivery as effectively as a physician. Women scheduled for a C-section will be randomly assigned to receive either standard doctor-led counseling or AI-delivered counseling with…

This trial tests whether a non-wearable audiovisual display, like a mobile screen showing calming content, can reduce anxiety in children aged 6 to 12 during emergency department procedures such as blood draws or stitches. Participants are randomly assigned to either use the dist…

Many cancer patients feel anxious before radiotherapy, partly due to unfamiliar equipment and procedures. This trial tests whether adding a simulation-based education session — a virtual preview of the treatment environment — before standard education can reduce that anxiety and …

This trial is testing whether a specially adapted form of cognitive behavioral therapy, called CBT-DAY, can reduce depressive symptoms in autistic youth aged 11 to 17. Participants will be randomly assigned to receive either CBT-DAY or standard care, and researchers will compare …

This trial tests whether a 12-week Latin dance program—featuring Rumba, Cha-cha, and Jive—can improve psychological health in primary school children aged 6 to 12. Participants are randomly assigned to either the dance program or regular physical education classes. Researchers wi…

This pilot trial tests a structured cognitive rehabilitation program called CanCOG® for cancer survivors who experience thinking difficulties—often called 'chemo brain'—after treatment for cancers outside the brain. Sixty adult survivors will be randomly assigned to either the si…

This study tests whether a daily probiotic supplement, Bifidobacterium longum 1714™, can improve wellbeing in adolescents aged 15-17 who report mild-to-moderate anxiety. Over 8 weeks, participants take one capsule daily and report changes in anxiety, sleep, fatigue, and cognitive…

This large citizen-science trial is testing whether two prebiotic products can reduce feelings of anxiety and improve related outcomes like sleep in adults. Around 1,000 participants will be randomly assigned to take either an active prebiotic or a placebo for 12 weeks, without k…

This trial tests whether a type of talk therapy called Acceptance and Commitment Therapy (ACT) can help cancer survivors and their spouses cope with the fear that cancer might return. It compares ACT to a more traditional therapy, Cognitive Behavioural Therapy (CBT), in a two-arm…

This trial tests whether box breathing — a technique of inhaling, holding, exhaling, and holding for 4 seconds each — can reduce anxiety, pain, and improve lung function in people undergoing colonoscopy. Half of the 68 participants will practice the breathing exercise before the …

This trial tests whether using virtual reality (VR) before an upper gastrointestinal endoscopy can reduce patient anxiety, improve psychological readiness, and boost satisfaction after the procedure. About 52 adults scheduled for the procedure will be randomly assigned to either …

This study tests whether virtual reality (VR) can reduce pain, fear, and distress in children aged 6 to 12 during burn dressing changes. Half of the participants will receive standard care plus VR distraction, while the other half receives standard care alone. Pain, fear, and dis…

This trial tests whether a structured education program, given to both breast cancer patients and their primary caregivers together, can improve self-care behaviors and reduce anxiety for patients, while also easing caregiver anxiety and burden. The program involves four weekly s…

This trial tests whether a culturally tailored mobile health program, called Self-Compassion, Health, and Empowerment (SHE), can improve mental health in Chinese immigrant women who have experienced intimate partner violence. Participants receive six weekly sessions covering safe…

This pilot study tests whether playing a collaborative virtual reality game during the first walk after scoliosis surgery can reduce pain and anxiety in teens aged 10 to 17. Half of the participants will use a VR headset to explore a magical jungle with a physiotherapist, while t…

This pilot study will test whether a 'Comfort Tote' filled with items like aromatherapy oils, stress balls, acupressure guides, and a journal can help teens aged 10-21 feel less pain, anxiety, and stress after scoliosis surgery. Half the participants will get a tote with therapeu…

This study tests a mobile health app called OPUCARE designed to support women with infertility who are about to undergo egg retrieval. The app provides medication reminders, treatment information, side-effect tips, and motivational messages. Researchers want to see if using the a…

This study tests whether a rapid, 5-day course of transcranial magnetic stimulation (TMS) can reduce PTSD symptoms in veterans. Ninety veterans with chronic PTSD who are still symptomatic despite ongoing treatment will receive either real TMS or a sham procedure. The goal is to s…

This trial is developing and testing a peer-led program called the Trauma Recovery Program for family members and significant others of people with borderline personality disorder. The program aims to reduce posttraumatic stress symptoms that can arise from living with or caring …

This trial investigates whether Benson Relaxation Technique (BRT), a 20-minute mind-body relaxation session, can reduce anxiety and depression in people who had an ischemic stroke 1-2 weeks earlier. Participants are randomly assigned to receive either BRT or health education twic…

This trial tests whether listening to white or pink noise through headphones can reduce pain and anxiety in children aged 7–12 during a routine IV insertion. One hundred fifty children will be randomly assigned to hear white noise, pink noise, or receive standard care. Researcher…

This study tests whether personalized feedback, based on real-time data from smartphones and wearable devices, can help Veterans with PTSD who use cannabis. The feedback aims to show how PTSD symptoms, cannabis use, and daily behaviors like sleep and activity are connected. The g…

This trial tests whether watching a 15-minute comedy video right before urodynamic testing — a procedure that can be uncomfortable and anxiety-provoking — helps reduce pain, anxiety, and improve readiness. About 68 adults having the test for the first time will be randomly assign…

This trial tests whether a guided digital program delivered through a mobile app can reduce anxiety and depression in young adults (ages 18–40) who have fertility-related distress after a cancer diagnosis. Participants use the app to complete four modules covering coping skills, …

This trial tests whether coloring mandalas for 20 minutes can lower anxiety, pain, and improve vital signs and satisfaction in men undergoing transurethral resection of the prostate (TURP). Half of the 64 participants will color a mandala before surgery; the other half will recei…

This trial tests whether a wearable device that gently stimulates the vagus nerve through the ear can reduce pain and PTSD symptoms in veterans who have both conditions. Participants receive six sessions of a brief PTSD therapy along with either active or sham stimulation over fo…

This trial tests whether a meditation-based program called Mantram Repetition Program (MRP) can help veterans who have both posttraumatic stress disorder (PTSD) and chronic pain. Participants will be randomly assigned to either MRP or a health education group. The study measures …

This trial tests whether squeezing a stress ball during coronary angiography — a common heart-imaging procedure — can lower patients' anxiety, fear, and physical stress while improving comfort. About 64 adults scheduled for elective angiography will be randomly assigned to either…

This pilot study tests whether a nurse-led digital cognitive behavioral therapy for insomnia (dCBT-I), delivered through a chatbot on WhatsApp, can help university students with mild to moderate anxiety or depression. Participants will complete a two-week daily sleep diary via th…

This trial tests whether watching a calming nature video through a virtual reality headset can reduce fear of childbirth and anxiety in high-risk pregnant women who are on bed rest in the hospital. Participants in the intervention group will view a VR nature scene with relaxing s…

This trial tests whether a simple mandala coloring activity can reduce perceived stress and anxiety in women hospitalized with high-risk pregnancies. Sixty participants will be randomly assigned to color mandalas daily for three days or to receive standard care. Stress and anxiet…

This study tests whether video-based education can reduce anxiety, correct myths, and boost motivation in first-time mothers. Pregnant women between 32 and 36 weeks will receive three educational video modules via WhatsApp alongside routine care. The goal is to see if this techno…

This trial tests a smartphone app called E-breathing that detects when a teen is feeling distressed and prompts them to practice slow-paced breathing. The study includes 100 adolescents aged 11 to 17 in Hong Kong who have at least mild symptoms of depression, anxiety, or stress. …

This study tests whether a 20-minute mandala coloring session can reduce childbirth fear and anxiety in fathers whose partners are giving birth for the first time. Fathers waiting outside the delivery room are randomly assigned to either color a mandala or receive standard care. …

This study tests whether an AI-assisted expressive writing program can reduce anxiety, emotional distress, and improve quality of life in adults receiving chemotherapy for any type of cancer. Participants are randomly assigned to either use the AI writing tool alongside their usu…

This study tests whether a gentle brain stimulation technique called tDCS can make a standard talk therapy for PTSD work better. Military personnel and veterans with both PTSD and a history of mild to moderate traumatic brain injury will receive five weekly sessions of written ex…

This pilot study tests a version of cognitive processing therapy (CPT) that has been adapted to also address stress from lived experiences, such as discrimination or identity-related challenges. The trial enrolls sexual and gender minority adults with PTSD who report distress fro…

This study tests whether a modified version of the Mitchell relaxation method can quickly improve heart rate variability—a marker of how well the heart handles stress—in people with high anxiety. About 122 adults aged 18 to 65 with elevated anxiety scores will be randomly assigne…

This study tests two psychological treatments—Acceptance and Commitment Therapy for Moral Injury (ACT-MI) and Present Centered Therapy for Moral Injury (PCT-MI)—in 180 veterans who have experienced moral injury from warzone deployment. The goal is to see which therapy better help…

This study tests whether applying mild electrical pulses (TENS) to the shins can reduce pain and anxiety in people receiving Botox injections into the bladder for overactive bladder. Participants are randomly assigned to receive either active TENS or a sham device during the inje…

This pilot study tests whether MyFILM, a 9-week group program using clips from the movie Inside Out, is feasible and acceptable for children aged 9-12 with mood or anxiety concerns. Participants attend weekly sessions to learn social-emotional skills and coping strategies. The st…

This study tests a computer-based cognitive training program called COGENT in veterans with PTSD. The program is designed to improve how people manage information in working memory, which may reduce cognitive disability and PTSD symptoms. Researchers will measure changes in think…

This study tests a 13-week remote stress recovery program for people who had a heart attack before age 55 and still feel distressed. The program includes online sessions with a therapist, a workbook, and videos. The goal is to see if a larger trial is possible by checking how man…

This trial tests whether an AI-enhanced mobile app called e-CAMP can improve mental well-being and reduce mild-to-moderate depression and anxiety in young adolescents aged 11 to 15. About 300 students from eight schools in Hong Kong will either use the app regularly for eight wee…

This study investigates whether the 4-7-8 breathing technique can help reduce pain and anxiety in people with type 2 diabetes and diabetic neuropathy during an electromyography (EMG) procedure. EMG can be uncomfortable and stressful, and this trial compares the breathing techniqu…

This study tests whether virtual reality (VR) and cold packs, alone or together, can reduce pain and anxiety in women after a cesarean section. About 120 women will be randomly assigned to receive VR, cold therapy, both, or standard care. The goal is to see if these drug-free app…

This study tests whether changing the environment—by playing relaxing music or dimming the lights—can lower anxiety in adults undergoing a urodynamic study, a test that measures how well the bladder stores and releases urine. About 220 participants with ongoing bladder symptoms w…

This study tests whether immersive virtual reality (VR) can lower stress, anxiety, and pain in adults undergoing their first central or midline catheter insertion. Participants use a VR headset showing calming nature scenes during the procedure. The goal is to see if this distrac…

This study tests whether adding a type of brain stimulation called intermittent theta-burst stimulation (iTBS) can help adults with post-traumatic stress disorder (PTSD) who do not improve enough with standard eye movement desensitization and reprocessing (EMDR) therapy alone. Pa…

This study tests whether showing an animated video or using therapeutic play before a throat swab can help children aged 4-8 feel less fear, anxiety, and distress. About 105 children will be randomly assigned to watch a short animation, engage in a playful activity, or receive st…

This study tests whether adding the sleep medication suvorexant to a shortened form of exposure therapy helps veterans with PTSD and insomnia. Participants take suvorexant or a placebo nightly for 8 weeks while attending weekly therapy sessions. Researchers measure changes in PTS…

This study tests a therapy program that combines acceptance and commitment therapy with virtual reality to help older adults (65+) manage anxiety symptoms. Participants attend 12 group sessions, some using VR, to learn psychological flexibility and reduce anxiety. The goal is to …

This study tests whether a set of four gentle osteopathic manual techniques can reduce stress and anxiety in young adults aged 18 to 35. Thirty participants will either receive the real techniques or a placebo simulation, and researchers will measure changes in heart rate variabi…

This study tests whether a virtual debriefing session with a maternal-fetal medicine specialist, held six to eight weeks after a delivery complicated by severe maternal morbidity (such as ICU admission or major blood transfusion), can lower symptoms of post-traumatic stress, depr…

This trial tests whether a dietary supplement called magnesium choline citrate can improve cognitive function and reduce anxiety in healthy adolescents and adults aged 8 and older. Over 84 days, participants take either the supplement or a placebo and complete questionnaires abou…

This study tests whether a virtual reality (VR) session the day before gallbladder surgery can lower patients' anxiety and uncertainty about general anesthesia. Two hundred adults who have never had anesthesia will either watch a VR video showing the operating room and anesthesia…

This study tests whether a 15-20 minute virtual reality (VR) relaxation session can reduce anxiety in adolescents aged 12 to 18 during a primary care visit. Participants use the Healthy Mind® VR platform to explore calming environments like beaches or mountains while doing guided…

This study tests whether a device that sends magnetic pulses to a specific brain area (dorsomedial prefrontal cortex) can safely reduce obsessive-compulsive behaviors in adults aged 22 and older. Participants receive either real or sham stimulation over six visits. The main goal …

This study tests whether watching a short educational video before surgery can lower anxiety in adults having elective procedures. Participants are randomly assigned to receive the video via a QR code they scan on their own phone, via a tablet provided in the waiting area, or to …

This study tests whether a short mindfulness exercise, followed by questions that help patients reflect on their experience, can reduce pain and anxiety after knee or hip replacement surgery. Adults who have had a joint replacement will receive a guided breathing exercise via tex…

This study tests whether using a virtual reality headset with guided imagery—like calming nature scenes and breathing exercises—can reduce pain, anxiety, and fatigue in women with breast cancer during chemotherapy. Participants are randomly assigned to either receive VR-guided im…

This study tests a mobile app called Maya that teaches cognitive behavioral therapy skills to adults who recently had a stroke and feel depressed or anxious. Ten participants will use the app for a few weeks to see if it is easy to use and helps improve their mood. The goal is to…

This study tests whether using a virtual reality headset (HypnoVR) during interventional radiology procedures can lower patients' anxiety and pain. Seventy adults will be randomly assigned to either use the VR headset or receive standard care. Researchers will measure anxiety wit…

This study tests a 3D-printed 'oxygen support cage' placed over the patient's head during cataract surgery. The cage lifts surgical drapes off the face, which may reduce feelings of suffocation and anxiety. Researchers will measure changes in blood pressure, heart rate, breathing…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study tests BraveBot, a computer program that talks with young people (ages 12-22) through their phone or computer while they do exposure therapy homework for anxiety or OCD. BraveBot does not replace the therapist but offers real-time coaching and encouragement during assig…

This study investigates whether a single session of whole-body hyperthermia (using an infrared sauna) can quickly improve symptoms of depression and anxiety. Researchers will measure brain activity, inflammation, and mood changes in four groups: healthy postpartum women, postpart…

This study will test whether smartphone sensors can detect when someone with early psychosis is feeling anxious or depressed and then offer a short mindfulness or psychoeducation exercise. Ten adults aged 18–50 with early psychosis and mild mood symptoms will use the app for 10 w…

This early-stage trial at the University of Chicago tests whether Adderall, a drug used for ADHD, can improve social interactions in people with PTSD. About 40 adults aged 18-65 will receive either Adderall or a placebo and rate their conversations. The goal is to see if this dru…

This study tests an 8-week group program that combines mindfulness, gentle movement, breathing exercises, healthy eating tips, and art activities for adults aged 55 and older with mild-to-moderate depression or loneliness. The goal is to see if the program improves mood, reduces …

This pilot study tests an 8-week group program designed to improve life balance for parents of preschool children. The program includes group sessions, personal goal setting, and phone check-ins. Researchers will measure changes in life balance, parenting stress, and mental healt…

This study tests a smartphone app that offers short mental health exercises for breast cancer survivors. The exercises target negative thinking, coping skills, and relaxation. The goal is to see if using the app for 8 weeks reduces anxiety and depression symptoms. The study will …

This study tests whether a structured debriefing session within 24 hours after a difficult birth can reduce post-traumatic stress and improve the birth experience. About 142 women who had an unexpected or adverse event during labor will be split into two groups: one gets usual ca…

This study tests whether using virtual reality (VR) for mindfulness can help people feel less anxious and experience less pain during minor vascular surgery done under local anesthesia. 160 adults with varicose veins will be randomly assigned to either wear VR glasses with guided…

This study tests whether giving caregivers hands-on practice plus a video to review at home improves their knowledge, skills, and stress levels when caring for a patient with a feeding tube (PEG). About 54 caregivers will be randomly assigned to either the video-enhanced training…

This study tests a 12-week telehealth program called PARTNER-MH, where trained peer specialists help minoritized veterans navigate mental health care, address social needs, and improve communication with clinicians. The trial will enroll 268 veterans with depression, anxiety, or …

This study tests whether a virtual reality (VR) tour of the hospital and operating room can help children aged 3 to 12 feel less anxious and scared before elective surgery. Half of the 56 children will use a VR program called NixiKit, while the other half will receive the usual p…

This study tests whether sophrology, a relaxation technique using gentle movements, breathing, and positive visualization, can reduce anxiety in cancer patients undergoing radiation therapy. Fifty-four adults with various cancers will be offered sophrology sessions during their t…

This study tests whether a gentle brain stimulation technique called tACS can make mindfulness therapy work better for people with generalized anxiety disorder. 99 adults will receive either real or fake tACS while doing mindfulness exercises. Researchers will track anxiety sympt…

This pilot study will test whether a 6-week app-based mental fitness program can improve wellbeing and self-compassion in anesthesiology residents. Sixty residents will be randomly assigned to either the mental fitness app or a control program. The main goal is to see if such a p…

This study tests a faster version of brain stimulation for generalized anxiety disorder. Instead of weeks of treatment, participants receive five sessions per day for five days. The stimulation is guided by each person's MRI scan to target a specific brain area linked to anxiety.…

This study tests a program called Natural Psychotherapy to see if it can reduce anxiety and depression symptoms in 3,000 Chinese students aged 7 to 18. Participants will be randomly assigned to the program or a control group, and their progress will be tracked for 6 months. The g…

This study tests whether structured play activities, done with a parent, can reduce anxiety in children with congenital heart disease before their surgery. About 204 children aged 0-12 will be randomly assigned to either receive therapeutic play plus standard care, or standard ca…

This study looks at whether taking a daily probiotic powder can help adults with overactive bladder (OAB) and anxiety. About 218 people will take either probiotics or a placebo for 12 weeks, while everyone also learns bladder training. The main goals are to see if probiotics redu…

This study compares ketamine to morphine for treating acute pain in children visiting the emergency department. Over 1,000 children with abdominal pain or broken bones will receive either drug. The goal is to see if ketamine works as well as morphine but with fewer side effects.

This study tests whether reading specific self-help books can lower anxiety, depression, and rumination in university students aged 18-25. 110 students from health science programs will be randomly assigned to read one of two books or join a waiting list. Over 8 weeks, they will …

This study will test two smartphone apps, Tankevirus and Grubl, designed to help people with mild to moderate anxiety and depression. About 1000 Norwegian adults will use one of the apps or a placebo app for two weeks. Researchers will measure changes in symptoms and quality of l…

This study compares an AI-delivered digital therapy called Nook to standard cognitive behavioural therapy (CBT) for people with moderate depression and/or anxiety. 400 participants aged 16-64 in the UK will be randomly assigned to either the AI program or human-led therapy. The g…

This pilot study will test whether a weekly 60-minute sound bowl meditation, offered for six weeks, can lower stress and anxiety in unpaid caregivers. Forty adult caregivers who have been helping a chronically ill or disabled family member or friend for at least six months will p…

This study tests whether doing a short 5-minute breathing or mindfulness exercise every day for a month can help Spanish-speaking university students feel less anxious and stressed. 240 participants will be split into four groups, each using a different technique like box breathi…

This study looks at two ways to inject botulinum toxin (like Botox) to treat long-term nerve pain from amputation in 100 combat veterans. The goal is to see which method—injecting inside the nerve or around it—works better for reducing pain and improving daily life. Participants …

This study tests whether a stellate ganglion block—a local anesthetic injection near nerves in the neck—can improve sleep and reduce stress in people with PTSD. Sixty adults with PTSD will receive two injections two weeks apart, and their sleep will be tracked with a smart ring f…

This study tests whether a virtual reality (VR) mindfulness program can help reduce anxiety in people who have had a stroke. About 48 adults who had a stroke more than 6 months ago and still feel anxious will use a VR headset for 9 sessions over 3 weeks. The goal is to see if thi…

This study tests a new online program called TEAM-LEADS designed to help teens and young adults (ages 13-22) with lupus or dermatomyositis reduce stress and improve heart-healthy behaviors like diet, exercise, and sleep. The program is self-guided and completed online. The study …

This study tests whether watching a short AI-generated educational video before a gynecological exam can reduce women's anxiety and increase their satisfaction. Researchers will enroll 114 women and measure their anxiety and satisfaction levels using standard questionnaires. The …

This study tests whether listening to calming music or using virtual reality can reduce pain, anxiety, and fear in children aged 6-12 with leukaemia who need care for painful mouth sores caused by chemotherapy. Forty-five children will be randomly assigned to a music group, a VR …

This study tests whether a mobile app called SocialRx, which recommends personalized arts and cultural activities, can improve depression, anxiety, and loneliness in teens aged 15-18. About 230 teens with depression or anxiety will either use the app for a year or continue their …

This study looks at whether a counseling approach called 'value clarification' can help women going through menopause feel better. It focuses on reducing symptoms like hot flashes, mood changes, and sleep problems, as well as easing depression, anxiety, and stress. About 88 women…

This study tests whether an AI-enhanced virtual reality cognitive behavioral therapy (VR/AI CBT) program can reduce anxiety and improve quality of life in people with inflammatory bowel disease (IBD). Seventy-six adults with IBD and moderate-to-severe anxiety will be randomly ass…

This study tests whether a warm foot bath combined with relaxation exercises can reduce pain and anxiety when chest tubes are removed after cardiac surgery. Sixty adults who had heart surgery will be randomly assigned to either relaxation exercises alone or relaxation plus a warm…

This study tests whether a specially designed AI chatbot can lower anxiety and trauma-related distress in adults recently diagnosed with cancer. Participants will use the chatbot for 12 weeks and complete surveys about their feelings and needs. The goal is to see if this digital …

This study tests whether an AI-assisted writing program can help Chinese teenagers (ages 10-19) who are struggling with prolonged grief after losing a loved one. Participants will complete three guided writing sessions over six days, with some receiving personalized AI feedback. …

This study tests whether two types of breathing exercises—pranayama and pursed-lip breathing—can reduce pain, anxiety, and improve vital signs in women after breast surgery. 126 participants will be randomly assigned to one of three groups: pranayama, pursed-lip breathing, or sta…

This study tests a program that combines yoga with cognitive behavioral therapy (CBT) to help people with Generalized Anxiety Disorder. Researchers will measure changes in anxiety levels, psychological resilience, and daily functioning in 64 adults. The goal is to see if this min…

This pilot study tests a 12-week mindful eating program called "Eat for Life" in 88 female nutrition students. The goal is to see if it reduces disordered eating, improves body appreciation, and boosts mental health compared to standard nutrition advice. Participants will complet…

This study tests a program called the Brave Elephant Program, designed to help shy preschoolers (ages 3-6) at risk for anxiety. The program trains teachers and uses classroom activities to build social skills and emotional strength. Researchers will check if the program is practi…

This study tests whether a dedicated 30-minute consultation with a healthcare professional before getting an implantable port (a small device under the skin for chemotherapy) can lower patient anxiety. About 150 adults scheduled for the procedure will either get standard care or …

This study tests whether a 10-week virtual group therapy, where people write about their traumatic experiences, can reduce PTSD symptoms in adults who also have borderline personality disorder (BPD) traits. The therapy is called Group Extended Written Exposure Therapy (GE-WET). R…

This study tests whether a group retreat using psilocybin (the active ingredient in magic mushrooms) can safely help healthcare clinicians who feel depressed and have lost meaning in their work. Seventy-two doctors, nurses, and physician assistants will take part in small groups,…

This study tests whether combining repetitive transcranial magnetic stimulation (rTMS) with expressive writing can reduce post-traumatic stress symptoms in adults. Forty-five participants who have experienced a traumatic event will be split into three groups: rTMS before writing,…

This study will test whether listening to an audiobook before total knee replacement surgery can lower patients' anxiety, blood pressure, and pulse rate. About 93 adults scheduled for elective knee replacement will be asked to use an audiobook app before their operation. Research…

This small study will test whether a type of brain stimulation called TMS can help new mothers with obsessive-compulsive disorder that started or worsened after childbirth. Fifteen women will receive 50 sessions over 10 days, along with brain scans and symptom checks. The goal is…

This study looks at whether virtual art therapy can help 62 patients in the coronary intensive care unit (ICU) feel less angry, anxious, and confused. Patients will use a tablet or screen to create art, and researchers will measure changes in vital signs, delirium risk, and menta…

This study looks at whether listening to music can help lower anxiety in adults who have been on a breathing machine for more than 21 days. Two hundred participants will either get standard care or also listen to calming music through headphones for 30 minutes, twice a day, for t…

This study compares two types of therapy for adults afraid of dogs, spiders, or snakes: one uses virtual reality (Doxy.me VR) and the other uses standard photos and videos. Both are delivered via telehealth. Researchers want to see if VR feels more realistic and reduces phobia se…

This study tests a single 90-minute therapy session for teens aged 13-18 who have experienced trauma and are waiting for longer treatment. The session teaches coping skills and understanding of trauma cues. About 40 teens in New Zealand will take part to see if this approach is p…

This study tests a small, non-drug device called ShotBlocker to see if it can reduce pain and anxiety when placing an IV. One hundred adults who need an IV will be randomly assigned to either use the ShotBlocker or receive standard care. The goal is to find a simple, low-cost way…

This study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…

This study will test whether listening to Turkish music after a planned cesarean section helps reduce pain, anxiety, and improve mother-baby bonding. Seventy first-time mothers will be enrolled. The researchers will measure pain and anxiety levels using standard scales and assess…

This study tests whether short, playful activities—like guided drawing, gentle body movement, and acceptance therapy—can reduce stress and anxiety in university students during exams. Sixty students will participate in a single 20-minute session, and a subgroup will have their br…

This study tests whether doing art activities (like drawing or painting) can reduce fatigue, anxiety, and improve quality of life in adults with blood cancers. Fifty-two patients will be split into two groups: one gets six art sessions over two weeks, the other gets standard care…

This early study tests whether a custom video game called Militant of the Maze can make exposure therapy for OCD more effective and engaging. Researchers will first have clinicians play and evaluate the game, then refine it and test it with a few non-clinician volunteers. The goa…

This study tests a structured education program for first-time pregnant women to reduce fear of childbirth and stress, and to strengthen their belief in normal birth. About 72 women in their third trimester will either receive the program or standard prenatal care. The goal is to…

This study tests whether a structured mandala activity program can reduce anxiety and improve emotional well-being in adolescents who have a sibling with special needs. Sixty-four teens will be randomly assigned to either participate in the mandala program or a control group. Res…

This study tests a non-invasive brain training method (neurofeedback) to reduce anxiety in people with chronic coronary syndrome who are at high risk for heart events. 214 participants will receive either real or sham feedback over 4 weeks. The goal is to see if this approach low…

This study tests an 8-week mindfulness program designed to help nursing students reduce stress, anxiety, and depression while improving their emotional control. About 93 students will learn meditation, breathing exercises, and mindful movement. The goal is to see if these techniq…

This study tests whether an AI-based rehabilitation program, combined with usual care, can reduce anxiety symptoms more than usual care alone. About 158 adults with anxiety disorders will use the AI system for 12 sessions over 3 weeks. The goal is to see if digital therapy can im…

This study tests an 8-week digital program that helps migrants in Sweden improve their mental health through better sleep, diet, physical activity, and social connections. 240 adults with moderate stress, anxiety, or depression will either get the program or a general wellness mo…

This study tests whether combining breathing exercises with progressive muscle relaxation can reduce shortness of breath, anxiety, and delirium in patients recovering from heart surgery. 116 adults will be randomly assigned to either receive these techniques plus standard care, o…

This study tests whether an interactive virtual reality (VR) program can help reduce pain, anxiety, and fatigue in 20 hospitalized palliative care patients. Participants use a VR headset with sensors to interact with a calming natural environment for 10 minutes daily over 14 days…

This study will develop and test a digital mental health program called 'VIBE in the Parks' for teens aged 13-24 who use Chicago Park District programs. About 268 participants will either get access to this program or a digital CBT workbook. The goal is to see if the program help…

This study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…

This study tests whether using an animal-shaped magic mirror during vaccination can reduce pain in children aged 1 to 4 years and lower anxiety in their mothers. About 126 mother-child pairs will take part, with some using the mirror and others receiving standard care. The goal i…

This study tests a personalized form of brain stimulation (PrTMS) for PTSD in 100 military veterans. Unlike standard treatments, it uses an EEG brainwave test to customize the therapy to each person. Participants will receive either active treatment or a sham version over 6 weeks…

This study will test whether an open-label placebo nasal spray (a spray with no active ingredients, clearly labeled as a placebo) can reduce stress in 260 adults about to do a canyon swing. Participants will either use the spray or receive no treatment. Researchers will measure s…

This study tests whether using a stress ball or receiving a hand massage during eye surgery can lower patients' anxiety, pain, and stress levels. 174 adults having eye surgery under local anesthesia will be randomly assigned to one of three groups: stress ball, hand massage, or s…

This study tests a supplement called MetaCalm to see if it can help healthy adults feel less stressed quickly. About 280 people will take one of two doses and report their anxiety levels over 6 hours. The goal is to see if MetaCalm lowers stress scores and also affects hunger and…

This study tests whether a short mindfulness program can lower anxiety and improve bonding for mothers whose babies are in the neonatal intensive care unit (NICU). 66 mothers will be randomly assigned to either the mindfulness program or standard care. The program includes four g…

This study will test whether listening to nature sounds or watching virtual reality nature scenes can reduce anxiety and improve comfort and satisfaction for pregnant women during a non-stress test (NST), a routine check of fetal well-being. Researchers plan to enroll 150 healthy…

This study tests whether a short animated video can lower anxiety in children (ages 4-10) getting a stem cell transplant and their parents. Half the families watch the video, the other half get standard verbal instructions. Researchers measure anxiety and satisfaction before and …

This study tests whether a smartphone app called SOLOMIYA is helpful and easy to use for people living under the stress of war in Ukraine. About 80 adults with mild to moderate depression or sleep problems will use the app for a few weeks. The app provides relaxation exercises, m…

This study tests whether listening to short, guided mindfulness audio recordings before and after surgery for a broken arm or leg can help reduce pain, anxiety, and the need for opioid painkillers. Fifty adults will be randomly assigned to either the mindfulness group or a contro…

This study tests whether squeezing a soft or spiky ball during a blood draw can reduce pain and anxiety in children aged 7 to 12. About 144 kids in a pediatric emergency setting will be randomly assigned to squeeze a soft ball, a spiky ball, or receive standard care. Their pain a…

This study tests a program called CommunityRx-Dementia, where trained peer mentors help caregivers of people with dementia. Over 12 months, caregivers get a personalized list of community resources, coaching, and supportive text messages. The goal is to reduce loneliness and help…

This study will test whether sacral massage (a massage on the lower back) can help reduce pain, depression, stress, and anxiety during labor. About 193 first-time mothers with a single, healthy baby will be randomly assigned to receive the massage or standard care. Researchers wi…

This study tests whether playing music through a sound shower in the ICU waiting room can reduce anxiety in family members. 224 adult relatives of intubated patients will be randomly assigned to wait with or without the music. Their anxiety levels will be measured using a standar…

This study looks at three simple methods—breastfeeding, using a stress ball, or wearing virtual reality goggles—to help first-time mothers feel less pain and anxiety during episiotomy repair (stitching) after giving birth. About 120 women will be randomly assigned to one of these…

This study looks at whether a back massage with mentholated ointment (like Vicks) can lower pain and anxiety in people who just had coronary bypass surgery. 120 adults will be split into three groups: one gets a back massage with mentholated ointment, one gets a back massage with…

This study looks at whether a supplement called Neurofast® can help people who have both anxiety and heart problems. 80 adults aged 18-70 will take the supplement or no extra treatment for 12 weeks. Researchers will measure changes in anxiety, heart rate, and blood pressure.

Many cancer survivors live with a persistent fear that their cancer will return, which can harm their mental health and daily life. This pilot study will test a type of talking therapy called metacognitive therapy (MCT) against relaxation therapy in 120 survivors. The goal is to …

This study tests whether a personalized AI-generated video, delivered by a nurse avatar, can improve recovery for people after coronary artery bypass surgery. About 128 patients will either get standard discharge instructions or the AI video plus standard care. Researchers will m…

This study tests whether 8 sessions of cognitive processing therapy (CPT), delivered online, can help women and birthing people who have post-traumatic stress disorder (PTSD) from a traumatic childbirth. The trial will enroll 29 participants to see if the therapy is practical, ac…

This study tests whether electroacupuncture (a type of acupuncture with mild electrical pulses) can reduce a group of common symptoms—pain, tiredness, sleep problems, anxiety, depression, and memory fogginess—in breast cancer survivors who are on hormone therapy. About 228 women …

This study will test an internet-based therapy program for people with emotional disorders like depression and anxiety. The program teaches skills to manage emotions and is designed to be used at home. Researchers want to see if it works well in primary care settings, if it is co…

This study tests whether taking a daily probiotic supplement for 8 weeks can reduce stress and anxiety in healthy university students during exam time. Two hundred students will receive either the probiotic or a placebo. Researchers will measure changes in stress, anxiety, sleep …

This study tests a device that gently stimulates a nerve in the ear during heart surgery. The goal is to see if it lowers the chance of postoperative delirium, anxiety, and depression. About 270 adults having elective heart surgery will be randomly assigned to receive real or sha…

This study looks at whether listening to music can help lower anxiety in people having surgery for the first time. Researchers will measure heart rate, blood pressure, and anxiety levels in 90 adults. Some will choose their own music, others will listen to a standard playlist, an…

This study tests whether playing a virtual reality music-movement game can improve mood and social connection in young adults aged 18-25 with mild to moderate depression or anxiety. Participants will be split into three groups: one playing a social VR game with others, one playin…

This study looks at two simple, drug-free methods—Helfer Skin Tap (gentle tapping near the injection site) and vibration—to see if they can lower pain and fear in children aged 5-10 getting a shot in the emergency room. About 186 children will be randomly assigned to one of these…

This study tests if a therapy called EMDR can reduce post-traumatic stress symptoms in parents whose baby was in the neonatal intensive care unit (NICU). About 80 parents with PTSD symptoms will be randomly assigned to get EMDR right away or after a waiting period. The goal is to…

This study tests whether watching a 360° relaxing nature video through a VR headset during a Pap smear can lower pain and anxiety. Sixty women aged 18–65 will be randomly assigned to either the VR group or standard care. Researchers will measure pain and anxiety levels to see if …

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) during breast cancer surgery can help prevent or reduce negative emotions like anxiety and depression after the operation. About 232 women will receive either real or sham stimulation for 30 minut…

This study tests whether a mindfulness training program can reduce depression, anxiety, and stress in pregnant women who did not plan or want their pregnancy but chose to continue it. Researchers will randomly assign 68 women in Turkey to either the mindfulness training or a cont…

This study tests whether Emotional Freedom Techniques (EFT) — a simple tapping routine — can reduce anxiety and fear in people about to have thyroid surgery. Seventy adults will be randomly assigned to receive EFT plus standard nursing care or standard care alone. Researchers wil…

This study tests whether a structured program where relatives provide sight, sound, touch, and smell stimulation to brain-injured ICU patients can reduce post-traumatic stress in those relatives. 200 family members will be trained and supervised to deliver the stimulation during …

This study looks at whether listening to music can help lower anxiety and improve sleep in people who have had a heart attack and are spending their first night in a special heart unit. About 64 adults will take part. They will listen to music and then use eye masks and earplugs …

This study tests a new way to help people going through alcohol withdrawal feel less anxious. It combines hypnosis with aromatherapy, using a calming scent to trigger the relaxation learned during hypnosis. About 80 adults in a hospital addiction unit will either get this combine…

This study looks at whether coloring mandalas (circular patterns) can help reduce anxiety and tiredness, and improve breastfeeding confidence and mother-baby bonding in women who had a C-section. About 140 new mothers will either color mandalas twice a week for 5 weeks or receive…

This study tests a program called REWIRE for teens aged 12-17 who feel anxious or depressed and use social media over 3 hours daily. The program aims to cut social media use by about half and replace it with positive offline activities like hobbies or time with friends. Researche…

This pilot study will test a 'blended' therapy approach for adults with emotional disorders like anxiety and depression. Participants will either receive standard face-to-face therapy, a mix of face-to-face sessions and a smartphone app, or be placed on a waitlist. The goal is to…

This study tests whether provoking OCD symptoms right before a gentle brain stimulation technique (tDCS) can boost its effects. About 178 adults with treatment-resistant OCD will receive either tDCS alone or tDCS preceded by symptom provocation. The goal is to see if the combined…

This study tests whether daily mindfulness exercises—like breathing and meditation—can reduce anxiety, depression, and poor sleep in women going through early menopause. Twenty women in Turkey will be split into two groups: one does mindfulness training for an hour, six days a we…

This study tests whether a four-week virtual yoga program can improve quality of life and reduce anxiety and depression in people going through IVF. About 80 participants will either take weekly yoga classes or continue with their usual care. Researchers will track changes in moo…

This study tests whether a non-invasive brain stimulation technique called tDCS, combined with computer-based cognitive training, can improve memory, attention, and multitasking in veterans with mild traumatic brain injury and PTSD. Forty-six veterans will receive either real or …

This study tests a drama-based coloring storybook called "Alican's Brave Journey" to see if it helps children aged 6-9 feel less fear, anxiety, and pain before and after surgery. 72 children having circumcision will be randomly assigned to either read the storybook or receive sta…

This phase 3 trial tests whether a slow-release form of melatonin can improve sleep in 120 children and adolescents (ages 2-17.5) with PTSD who have significant sleep disturbances. Participants will receive either melatonin or a placebo for 13 weeks. The study aims to see if mela…

This study looks at whether a program combining yoga, meditation, and mindful eating can lower stress, anxiety, and depression in university students. Sixty students will attend weekly sessions for a semester and fill out questionnaires to measure changes. The goal is to see if t…

This study tests whether combining relaxation exercises with listening to a specific Quran chapter (Surah Ar-Rahman) can reduce anxiety and improve sleep in people undergoing kidney dialysis. 76 adult Muslim patients will be split into two groups: one doing the relaxation and Qur…

This study tests whether using a cold spray or a Buzzy device (a vibrating cold pack) can reduce pain and fear during penicillin injections. Ninety adults receiving intramuscular penicillin will be randomly assigned to one of three groups: cold spray, Buzzy device, or standard ca…

This study tests whether a single session of computer-based cognitive bias modification can reduce social anxiety in 130 Pakistani university students aged 18 to 25. Participants will either receive the active training or a control version, and their anxiety levels will be measur…

This study tests a non-invasive brain stimulation method called cTBS for treating generalized anxiety disorder. 60 adults will receive either real or sham stimulation to two brain areas over 7 days. Researchers will measure changes in anxiety symptoms and brain activity using MRI…

This study tests whether a mindfulness-based nursing program can lower anxiety and help stabilize blood pressure in 60 adults undergoing planned open heart surgery. Participants will receive the mindfulness intervention before and after surgery, and their anxiety levels and vital…

This early-stage study tests a brief couples therapy for 80 Veterans with PTSD and alcohol use disorder. Veterans receive individual treatment while attending 3-4 sessions with their romantic partner. The goal is to see if involving loved ones improves treatment satisfaction and …

This study will test a one-day acceptance and commitment therapy (ACT) program for 50 veterans who have both inflammatory bowel disease (IBD) and a mental health condition like depression, anxiety, or PTSD. The goal is to see if this brief therapy can improve their quality of lif…

This study tests whether listening to music with binaural beats (a type of sound that may influence brain activity) can help professional athletes who are afraid of getting hurt again after a musculoskeletal injury. Sixty-six athletes will listen to either binaural beat music, a …

This study compares a new trauma-focused therapy (MBT-TF) with standard therapy for adults who have both borderline personality disorder and complex PTSD. The goal is to see if the new approach is practical and helpful for reducing symptoms. Forty participants will be followed fo…

This study looks at whether listening to guided meditation audio can reduce stress and anxiety in people having open-heart surgery. About 72 adults will either receive meditation sessions or standard care. Researchers will measure stress hormones, blood sugar, and anxiety levels …

This study compares hypnosis, virtual reality, and standard care to see which best reduces anxiety in adults starting chemotherapy for acute myeloid leukemia. About 99 patients will be randomly assigned to one of three groups. The goal is to find a non-drug way to help patients c…

This study tests whether using RELAX glasses—a device that plays calming videos and sounds—can lower anxiety in ICU patients during invasive procedures like getting an IV or a catheter. About 456 adults in intensive care will either use the glasses or receive standard care. Their…

This study tests whether internet-based group cognitive behavioral therapy (CBT) delivered over Zoom can reduce symptoms of anxiety and depression in international students in Malaysia. About 128 students with moderate to severe symptoms will be randomly assigned to either the th…

This study tests whether individual psychotherapy, group therapy focused on body image, or a mix of both can improve quality of life and reduce anxiety in women with endometriosis. Forty women will be randomly assigned to one of three therapy programs or a control group. The goal…

This study tests a web-based program called TOUCHMinds designed to help teenagers aged 15-17 who have anxiety symptoms or anxiety disorders feel more comfortable seeking help. The program includes six self-guided online modules and three video sessions with a psychologist. Resear…

This study tests whether adding virtual reality (VR) sessions to standard counseling helps university students with public speaking anxiety more than counseling alone. About 72 students will be randomly assigned to either counseling only or counseling plus VR exercises that simul…

This study will follow 120 people with chronic pain, nerve damage from chemotherapy, radiation side effects, or slow-healing wounds who are referred for ozone therapy. Researchers will track changes in quality of life, pain, and other symptoms over several months. The goal is to …

This study looks at whether using a weighted blanket can reduce nighttime leg cramps, improve sleep quality, and lower anxiety and stress in pregnant women. Fifty women in their third trimester will use the blanket for 14 days and compare results to a 14-day period without it. Th…

This study tests whether adding a device that turns body movements into sound can help people with acute stress disorder (ASD) feel more connected to themselves. Thirty adults who recently experienced a traumatic event will receive standard therapy plus this 'movement sonificatio…

This study tests whether very short (4 or 8 sessions) psychological treatments can reduce symptoms of anxiety, depression, and stress-related physical complaints. About 184 adults with mild to moderate symptoms will be randomly assigned to group or individual therapy, or a relaxa…

This study tests whether using a virtual reality headset during a breast biopsy can lower depression, anxiety, and stress. 80 women will either wear a VR headset showing calming nature scenes or receive standard care. Researchers will measure their mood before and after the proce…

This study tests a program that combines doctor care, digital tools, virtual reality, and school-based support to help teens and adults in Morocco with depression and anxiety. About 146 participants will be split into two groups: one gets the new program, the other gets usual car…

This study tests whether a short, intensive psychological program before lung cancer surgery can lower anxiety and depression. About 138 adults scheduled for lung cancer surgery will be split into three groups: one receiving four weekly therapy sessions, one refusing support, and…

This pilot study will test whether a program called Facing Your Fears can help reduce anxiety in 24 children aged 12-18 who have both autism spectrum disorder and intellectual disability. The program uses cognitive behavioral therapy techniques like gradual exposure to feared sit…

This pilot study tests whether a dietary supplement made from Leonurus cardiaca (motherwort) can reduce anxiety in adults with Generalized Anxiety Disorder. Sixty participants aged 20-50 will take either the supplement or a placebo for 30 days. Researchers will measure changes in…

This study tests a one-week course of brain stimulation (called iTBS) for veterans who have both PTSD and chronic pain. Thirty veterans will receive 5-6 short sessions each day for five days, with no placebo group. Researchers will track changes in PTSD symptoms, pain, mood, and …

This pilot study will test a new type of talk therapy called ACT-SHARE for veterans who have both PTSD and alcohol problems and are struggling with conflict in their romantic relationships. The therapy aims to help veterans manage difficult thoughts and feelings and take actions …

This study tests whether a digital monitoring device called Dalia can improve depression symptoms when added to usual care. About 644 adults with moderate-to-severe depression will use the device for 3 months. The main goal is to see if more people feel significantly better compa…

This study tests a therapy called CFTSI for children aged 7 to 17 who have experienced a traumatic event in the last 3 months. The goal is to see if CFTSI reduces post-traumatic stress symptoms better than standard supportive therapy. 140 children and their families will take par…

This study looks at whether watching a virtual reality (VR) video can help children aged 7 to 12 feel less pain and fear when getting an IV. About 150 kids having day surgery will be randomly placed into one of three groups: watching an aquarium video, a kaleidoscope video, or ge…

This study tests a smartphone app called ZeroOCD that uses augmented reality to help people with contamination OCD face their fears. About 189 adults with OCD symptoms will be randomly assigned to use the app, receive standard therapy by video, or join a waitlist. The goal is to …

This study tests whether an 8-week internet-based cognitive behavioral therapy (ICBT) program can help adults with generalized anxiety disorder or major depressive disorder. Participants in Taiwan will either receive standard care alone or standard care plus the online program, w…

This study compares an AI-powered orientation program to one given by human nurses for patients in the intensive care unit (ICU). The goal is to see if the AI program helps patients have more days without delirium, lowers anxiety and depression, and shortens their hospital stay. …

This study tests whether a 4-week program combining ergonomic training with exercise can reduce pain, improve sleep quality, and lower anxiety in nursing students. Sixty participants will be randomly assigned to either the program or standard curriculum. The goal is to see if the…

Researchers at the National Institute of Mental Health are studying how everyday feelings, like stress or frustration, influence decision-making. They will follow 420 adults aged 18 to 55, including healthy volunteers and people with varying levels of depression, anxiety, or addi…

Researchers at Emile Muller Hospital in Mulhouse, France, want to estimate how many mothers develop post-traumatic stress disorder after giving birth. About 1,000 women who deliver at the hospital are asked to fill out the City Birth Trauma Scale and a short survey about their he…

Researchers at Assiut University Hospitals are studying how often adults with multiple sclerosis also get primary headaches such as migraine and tension-type headache. About 100 patients will complete a single visit that includes a neurological exam, headache history, disability …

Researchers at Shanghai Mental Health Center are following 500 people with obsessive-compulsive disorder to see how symptoms, daily functioning, and treatment responses change over time. The study includes adults aged 18 to 60, including some who have never received OCD treatment…

This study compares 200 people with alcohol use disorder to healthy volunteers using questionnaires that measure psychological processes and emotional symptoms like depression and anxiety. The goal is to identify differences in how people think and cope. It is purely observationa…

This trial is testing a device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works in people. Participants will be monitored for safety and any effects. The study is still ongoing, and details about who can join are not yet …

This study aims to develop and pilot a program for people with HIV in South Africa who also face depression, trauma, and food insecurity. Researchers will first explore how these problems interact, then create a treatment called CBT-SA that combines therapy, nutrition support, an…

This study looks at whether mindfulness-based stress reduction can help Black teenage girls who have been involved with the justice system and their parents or caregivers. About 90 participants will report on stress, PTSD symptoms, and other outcomes before and after the program.…

This trial tests whether practicing mosaic art for six weeks helps midwifery students improve the fine motor skills needed for episiotomy repair, a common procedure after childbirth. Researchers will compare 106 third-year students who do mosaic art before standard training with …

Researchers at Assiut University are asking whether ADHD symptoms in medical students are linked to depression, anxiety, and lower grades. About 52 undergraduate medical students will fill out questionnaires that screen for adult ADHD, depression, and anxiety. The study also coll…

This trial compares three simulation-based approaches for teaching subcutaneous injections to first-year midwifery students. One group practices on a mannequin, another on a training pad placed on a peer's abdomen, and a third on a pad placed on their own abdomen. Researchers wil…

This study tests a mobile health program called SAMU to help adults in Uganda who have HIV, high blood pressure, and mental health issues like depression or anxiety. About 1,500 participants will use their phones for mental health screening and get connected to care. The goal is …

This study explores whether brain activity and sleep patterns can predict how well people with PTSD respond to Written Exposure Therapy, a brief therapy involving structured writing about a traumatic event. About 200 adults with PTSD will be randomly assigned to either this thera…

This study follows 400 adults with generalized anxiety disorder (GAD) to understand how symptoms and health change over time. Researchers will collect clinical assessments, blood samples, and brain measurements at multiple visits. The goal is to identify factors that may predict …

This study looks at whether the ratio of the second to fourth finger (2D:4D) is linked to anxiety and work stress in anesthesiology residents. Researchers will measure finger lengths and use a questionnaire to assess worry and anxiety in about 116 residents aged 20-35. The goal i…

This study asks whether routine medical data can predict which survivors of an emergency intensive care unit (EICU) stay will develop post-traumatic stress disorder (PTSD) one month after leaving the hospital. Researchers will follow about 800 adult patients, collecting details f…

This study tests whether a non-invasive brain stimulation technique called theta burst stimulation (TBS) can change how people remember the order of emotional movie clips. Researchers will compare active TBS to a sham (fake) version in 120 healthy adults. The goal is to understan…

This trial tests whether a scenario-based simulation training session can reduce anxiety, boost self-confidence, and improve clinical skills in nursing students when counseling pregnant women about nutrition. Half of the participants will take part in a 20-minute simulated counse…

This study explores how financial insecurity—such as trouble paying for housing, food, or healthcare—affects the mental health of university students and whether it keeps them from seeking help. Researchers will conduct in-depth interviews with 30 students from two French univers…

This study investigates how often older adults in China experience anxiety and depression before undergoing major non-cardiac surgery. Researchers will use standard questionnaires to screen 8,000 patients aged 65 and older across multiple hospitals. The goal is to better understa…

This study follows 200 children and teens aged 7-17 who are at higher risk for depression, anxiety, or obsessive-compulsive disorder (OCD) due to family history or early symptoms. Over two years, researchers will use interviews, questionnaires, brain scans (EEG and MRI), and biol…

This study explores whether estrogen influences how the brain processes fear, focusing on postmenopausal women who experience natural declines in the hormone. Participants will take an estradiol tablet and undergo brain scans while viewing shapes that sometimes predict a mild ele…

This study investigates how common depression is among adults who received a liver transplant more than five years ago. Researchers will use questionnaires and interviews to assess mental health and identify factors that may predict depressive symptoms. The goal is to better unde…

This study is testing a new online program called Whole Selves, designed specifically for transgender and nonbinary young adults. The program helps them think about their alcohol use and romantic relationships in a way that fits their experiences. About 107 people will try the pr…

This study tests whether a non-invasive finger sensor, called the Nociception Level (NOL) Index, can objectively measure pain, anxiety, and uterine activity in awake women undergoing elective cesarean delivery under spinal anesthesia. Researchers will monitor 100 women and compar…

This study uses an anonymous online questionnaire to examine how medical students, midwifery students, and academic hospital staff use substances like alcohol, tobacco, and stimulants, and how these behaviors relate to mental health, stress, and social factors. The goal is to ide…

This study asks whether post-traumatic stress disorder (PTSD) influences how well epilepsy surgery works. Researchers will follow 42 adults with drug-resistant focal epilepsy for two years after surgery, comparing seizure freedom and quality of life between those with and without…

This observational study asks whether a parent can accurately gauge the pain their child feels during a dental local anaesthetic. Children aged 6 to 15 and their parents each rate the child's pain on a 0-10 scale after the procedure. The goal is to see if parents can serve as rel…

This study follows 500 adults with open limb injuries from drone attacks to understand why some develop severe wound infections. Researchers will collect detailed medical data to link the extent of tissue damage with infection outcomes. The goal is to improve early identification…

This study looks at severely injured adults with multiple traumatic injuries who receive one or more nerve blocks for pain. Researchers want to see if having more blocks improves pain control, reduces opioid use, and helps patients regain mobility faster, or if it increases risks…

This study looks at whether feeling anxious before an ERCP procedure makes the experience more uncomfortable or harder for patients to cooperate. Adults undergoing ERCP with conscious sedation will fill out anxiety questionnaires before and comfort surveys after the procedure. Do…

This study investigates the experiences of healthcare professionals, patients, and families in high-acuity hospital settings like emergency rooms and intensive care units. Researchers aim to understand less visible contributions such as teaching, coordination, and emotional suppo…

This study looks at moral injury—a type of distress that happens when workers cannot act according to their values—among healthcare professionals in psychiatric facilities in the PACA region of France. Researchers will survey about 2,688 workers to understand what causes this suf…

This study looks back at the medical records of 300 people with arrhythmogenic cardiomyopathy who have an implantable cardioverter-defibrillator (ICD) and have had dangerous heart rhythms. Researchers want to count how often ICD-related problems occur, such as lead failure or ina…

This study looks for brain-based markers (biomarkers) of obsessive-compulsive disorder (OCD) in people with severe, hard-to-treat symptoms. Participants complete decision-making tasks and are exposed to personal OCD triggers while their brain activity is recorded with EEG and the…

This study will examine whether certain RNA molecules in the blood are different in people with psychiatric disorders like schizophrenia, depression, bipolar disorder, OCD, and panic disorder. Researchers will compare these molecules in patients who are not currently on medicatio…

This study will follow 45,000 university students over three years to understand how financial struggles, housing issues, and loneliness affect their mental health and whether they seek help. Participants will fill out questionnaires about their well-being and life circumstances.…

This pilot study will examine whether certain genes related to serotonin are linked to gut bacteria that process tryptophan in adults with depression, anxiety, PTSD, or panic disorder. Thirty participants will provide saliva and stool samples from home. The goal is to gather info…

This study looks at brain activity recorded from deep brain stimulation (DBS) devices in 20 people with Parkinson's disease. Researchers want to see if certain brain signals are linked to symptoms like sudden anxiety, impulse control problems, and hallucinations. Participants wil…

This study tests whether a wrist-worn biosensor can detect changes in the body's stress response during ketamine-assisted therapy for PTSD. Five adults will wear the device before, during, and after therapy sessions. The goal is to see if a specific pattern of nervous system acti…

This study looks at whether a type of brain stimulation called transcranial magnetic stimulation can help people with OCD shift their behavior more flexibly. It involves 12 participants who will receive three daily sessions of stimulation. The goal is to see if the procedures are…

This study follows 75 volunteer first responders who are alerted via a smartphone app to help in out-of-hospital cardiac arrests. Researchers want to understand how these stressful events affect the volunteers' mental health and whether a structured follow-up conversation can hel…

This study will test a customized online health program for Canadian women Veterans and their families. The program includes health missions, peer support, and social connection to encourage physical activity and healthy habits. Researchers will track how many people complete the…

This study aims to adapt a digital mental health app called Wysa for adolescent girls aged 13-18 in rural Uttar Pradesh, India, who have anxiety or depression. Researchers will work with the girls, their families, and community members to identify what helps or hinders app use an…

This study tests a web-based toolkit that helps healthcare providers screen for intimate partner violence and mental health issues in patients receiving treatment for opioid use disorder. About 792 patients and their providers will use the toolkit during routine care to see if it…

This study will enroll 500 adults with high levels of repetitive negative thinking (like worry or rumination) to understand why cognitive-behavioral therapy helps. Participants will receive one of two digital therapy programs: one focusing on concrete thinking, the other on self-…

This study examines how 180 adolescents aged 14-18 with trauma-related symptoms react to stress and strong emotions. Researchers will measure brain activity, heart rate, and anxiety while teens repeatedly imagine details of their own traumatic event. The goal is to understand whi…

This study looks at how low levels of carbon monoxide (CO) from smoking or the environment affect pain, senses, anxiety, and depression. Researchers will measure CO in the breath of 70 healthy adults and test their pain threshold and mood. The goal is to better understand CO's su…

This study looks at whether giving both food assistance and psychological counseling helps young adults aged 18-25 who face food insecurity and mental health issues. Participants will receive weekly food aid for a year, and half will also get twice-monthly therapy for six months.…

This study looks at whether an 8-week CrossFit program can make kids aged 7 to 11 stronger, fitter, and happier. Thirty children will be split into two groups: one does CrossFit twice a week, the other continues their normal routine. Researchers will measure physical changes like…

This study tests a nursing program that uses motivational interviewing to help rural women feel less afraid of cervical cancer and more willing to get screened. Eighty women aged 30-65 will take part in four weekly one-on-one sessions. Researchers will measure changes in their he…

This study follows 120 people with laryngeal cancer to see how their quality of life, voice, swallowing, pain, and mood change before treatment and at 3, 6, and 12 months after. Researchers will use questionnaires to track these changes. The goal is to better understand recovery …

This study looks at how emotional state influences the course of functional dyspepsia and irritable bowel syndrome in 150 adults. Participants will fill out questionnaires about their quality of life, mood, and anxiety at the start and after treatment. The goal is to better under…

This observational study will test whether a 1-3 minute AI-powered facial scan can accurately measure vital signs like heart rate and blood pressure, as well as estimate blood sugar, cholesterol, and mental health status. Researchers will compare the scan results with standard me…

This study looks at how anxiety and depression influence shared decision-making in patients aged 65 and older with critical limb threatening ischaemia (CLTI), a severe form of leg artery disease. Researchers will interview patients, their carers, and healthcare staff to understan…

This observational study will follow 250 adults treated in the emergency department for major trauma. Researchers want to see if early factors like thinking flexibility, social support, and stress levels can predict who develops PTSD within 6 months. Participants fill out questio…

This study looks at whether a video-supported flipped learning model can lower anxiety and improve skill levels in midwifery students learning episiotomy. About 60 third-year midwifery students will be split into two groups: one gets traditional classroom teaching, the other watc…

This observational study looks at 85 adults with Bell's palsy to see if worse facial muscle function is linked to higher anxiety, depression, and lower self-esteem. Researchers will measure facial movement and muscle activity, then compare those results with participants' answers…

This study follows 300 Ukrainian veterans who lost a limb in combat to see if longer evacuation times or extended tourniquet use increase the risk of developing PTSD. Participants will be monitored for 18 months using PTSD symptom questionnaires. The goal is to identify factors t…

This study tests a short media campaign (about 3-5 minutes) designed to encourage parents and caregivers in Nigeria to vaccinate their children. The campaign aims to reduce vaccine hesitancy, address fears, and improve vaccine access. About 74 participants whose children are not …

This study will survey 160 adults on long-term hemodialysis at Sohag University Hospital to find out how many experience anxiety or depression. Researchers will also look for links to age, gender, and other health factors. The goal is to better understand the mental health needs …

This study will follow 120 adults receiving a steroid injection for lower back and leg pain caused by a slipped disc. Researchers want to see how factors like anxiety, pain during the procedure, and sedation affect how satisfied patients feel one hour after the injection. The goa…

This study tests whether giving mothers online training about introducing solid foods helps their babies grow and develop better. 132 mothers and their 5-month-old babies will take part. The training covers feeding behaviors, and researchers will measure baby growth, development,…

This study looks at how certain brain circuits cause strange sensory feelings in people with Obsessive-Compulsive Disorder (OCD). It will test if a non-invasive brain stimulation technique called rTMS can reduce these symptoms. The study involves 120 adults with OCD and healthy v…

This study will observe 300 people with long-term jaw and face muscle pain (TMD) to see how psychological factors relate to their physical symptoms. Participants will fill out questionnaires about their pain and other body symptoms. The goal is to better understand the role of me…

This study follows 150 adults with severe arm or leg injuries that required a tourniquet to stop bleeding. Researchers will track how long the tourniquet was used and check for pain, nerve damage, and recovery over 6 months. The goal is to see if longer tourniquet use increases t…

This study looks for biological markers in tumor tissue and blood that may be linked to anxiety and depression in people with solid tumors. Researchers will combine psychological assessments with lab tests to better understand these emotional struggles. The goal is to improve ear…

This study looks back at data from 80 veterans and first responders who completed a 12-week program that combined mental health support, physical therapy, nutrition advice, and occupational therapy. Researchers want to see if the program helped improve sleep, anxiety, depression,…

This early-stage study looks at how the drug buagafuran (AF-5) behaves in people with liver impairment compared to those with normal liver function. Twenty-four adults will receive a single 30 mg dose, and researchers will measure drug levels in the blood and monitor safety. The …

This study looks at how fear of movement (kinesiophobia) affects daily function in people with rheumatoid arthritis. Researchers will compare 200 RA patients with 200 healthy volunteers to understand links between fear, pain, fatigue, mood, and muscle loss. The goal is to find no…

This study tests whether a short educational video, shown alongside standard information, can help first-time heart attack patients better understand their upcoming heart catheterization and feel less anxious. About 140 participants will be randomly assigned to receive either sta…

This study looks at how nomophobia (fear of being without a phone) affects anxiety and academic confidence in university students who have text neck (neck pain from looking down at phones). Researchers will survey 396 students aged 18-35 who use smartphones at least 3 hours daily…

This study looks at how trauma exposure relates to suicidal thoughts and behaviors in teenagers aged 11 to 17 who are in psychiatric hospitals. Researchers will compare teens admitted for suicide attempts with those admitted for other reasons. They will use questionnaires and blo…

This study is creating a decision-support tool called CRAFTT to help therapists tailor mental health treatments to the cultural values and experiences of Latine youth (ages 5-15). The goal is to improve how well these treatments work and reduce mental health disparities. Research…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…

This study will survey 400 adults visiting a urology clinic for the first time. Researchers want to learn if patients who use AI chat tools (like ChatGPT) before their appointment feel more or less anxious, satisfied, and informed compared to those who don't. Participants fill ou…

This study looks at how menopause changes the way the body processes escitalopram, a common antidepressant. Researchers will measure drug levels in the blood of 94 women aged 40-60 who are premenopausal or menopausal and taking the medication for depression or anxiety. The goal i…

This study checks if an AI software can accurately measure depression and anxiety symptoms in 650 adults. Participants will have their symptoms rated by both the AI and human experts to see if the AI works well across different groups. The study does not provide any treatment—it …

This study will test a digital tool called AI-COA® to see how well it measures the severity of depression and anxiety compared to standard clinician ratings. About 150 adults in the U.S. who are starting a new treatment for depression or anxiety will use the tool over 12 weeks. T…

This study looks at whether teaching patients about catheter care can improve their attitudes toward preventing infections and lower their anxiety after urologic surgery. About 70 male patients who go home with a urinary catheter will receive a training booklet based on daily liv…

This study examines how regular blood transfusions (exchange transfusions) affect thinking speed in adults with severe sickle cell disease. Researchers will test 85 participants remotely using a simple symbol-matching task and other cognitive assessments at different points in th…