Scientists zap brains to unlock anxiety secrets

NCT ID NCT07415772

Not yet recruiting Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 11, 2026 · Updated 2 times

Summary

This study uses a non-invasive brain stimulation technique called TMS to temporarily change activity in a brain region linked to anxiety. Researchers will use fMRI scans to see how this affects brain connections and anxiety-related startle responses. 140 adults with anxiety will receive either real or sham TMS. The goal is to understand how TMS might work to reduce anxiety, which could lead to better treatments in the future.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Transcranial Magnetic Stimulation (TMS)
What this could lead to: If successful, this could reveal how TMS changes brain activity related to anxiety, pointing toward more effective, non-invasive treatments.
What could go wrong: This is an early mechanistic study, not a treatment trial. It may not lead directly to a therapy, and results may not apply to all anxiety patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY

Contacts and locations

Locations

University of Pennsylvania

Philadelphia, Pennsylvania, 19104-6013, United States

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