Could a Stress-Blocking drug help veterans with PTSD?
NCT ID NCT07187011
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2a trial will test whether PT150, a drug that blocks a stress-related receptor, can safely reduce PTSD symptoms in 120 US veterans. Participants will receive either PT150 or a placebo for several weeks, and researchers will track changes in PTSD severity and side effects. The goal is to see if PT150 is promising enough for larger studies.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
PT150 (a drug that blocks glucocorticoid receptors)
What this could lead to
If successful, this could point toward a new treatment option for PTSD in veterans, potentially easing symptoms like intrusive thoughts and hyperarousal.
What could go wrong
This is an early Phase 2a trial with only 120 participants, so results may not apply broadly. The drug may cause side effects or fail to outperform placebo.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Jennifer Moreno Department of VA Medical Center
San Diego, California, 92161, United States
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Michael E DeBakey VA Medical Center
Houston, Texas, 77030, United States