Could a sleep hormone replace standard sedation for Kids' surgery?

NCT ID NCT07336095

Not yet recruiting Symptom relief Sponsor: Ain Shams University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares melatonin, a natural sleep hormone, to midazolam, a common sedative, for calming children before tonsillectomy. About 195 children will receive either melatonin or midazolam before surgery. The goal is to see if melatonin reduces anxiety and confusion after waking up from anesthesia, with fewer side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: melatonin
What this could lead to: If melatonin works as well as midazolam, it could offer a safer, more natural option to calm children before surgery with fewer side effects.
What could go wrong: This is a single-center trial with 195 children, so results may not apply to all kids. Melatonin may not be as effective as midazolam for some children.

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Conditions

The condition(s) this trial relates to.

anxiety anxiety disorder Emergence Delirium primary interstitial lung disease specific to childhood

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANXIETY CHILD EMERGENCE DELIRIUM, ANESTHESIA MELATONIN BIOAVAILABILITY MIDAZOLAM PREMEDICATION TONSILLECTOMY

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