Veterans' brain scans could unlock new suicide prevention strategies

NCT ID NCT06355284

Completed Knowledge-focused Sponsor: VA Office of Research and Development Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 08, 2026 · Updated 3 times

Summary

This pilot study uses functional MRI to examine brain activity in trauma-exposed veterans with obsessive-compulsive personality traits, known as overcontrol. Overcontrol can strain relationships and increase suicide risk. The study aims to test whether the brain scanning methods and remote monitoring tools are practical and acceptable for future research. If the methods work, they could help develop new treatments that combine brain stimulation with therapy.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Functional MRI (brain scanning during cognitive tasks)
What this could lead to: If successful, this study could pave the way for new treatments that combine brain stimulation with therapy to improve social skills and reduce suicide risk in veterans.
What could go wrong: This is a very early pilot study with only 59 participants, focused on testing methods, not treatment. The results may not apply to all veterans or lead directly to new therapies.

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Conditions

The condition(s) this trial relates to.

obsessive-compulsive personality disorder post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

COMPULSIVE PERSONALITY DISORDER STRESS DISORDERS, POST-TRAUMATIC

Contacts and locations

Locations

Providence VA Medical Center, Providence, RI

Providence, Rhode Island, 02908-4734, United States

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