Could a common supplement help Treatment-Resistant OCD?

NCT ID NCT06956157

Ongoing Disease control Sponsor: Guangdong Provincial People's Hospital Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tests whether adding N-acetylcysteine (NAC) to standard treatment can help people with obsessive-compulsive disorder (OCD) that hasn't improved with other medications. Researchers will measure brain glutamate levels and symptom changes in 90 participants over 12 weeks. The goal is to understand how NAC affects brain chemistry and whether it can reduce OCD symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: N-acetylcysteine (NAC) tablets
What this could lead to: If it works, this could point toward a new add-on treatment for people with OCD that hasn't responded to standard medications.
What could go wrong: This is a small, early-phase study focused on brain changes, not yet proven to improve symptoms. NAC is generally safe but may cause side effects like nausea or headache.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

neurotic excoriation obsessive-compulsive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OBSESSIVE COMPULSIVE DISORDER (OCD)

Contacts and locations

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Locations

Guangdong Mental Health Center, Guangdong Provincial People's Hospital

GuangDong, Guangdong, 510120, China

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