New study tests common antidepressant for PTSD in military and civilian groups

NCT ID NCT05422612

Terminated Symptom relief Sponsor: Global Coalition for Adaptive Research Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 2 times

Summary

This phase 2 study is testing whether fluoxetine, a widely used antidepressant, can reduce PTSD symptoms in 800 adults including active-duty service members, veterans, and civilians. Participants receive either fluoxetine or a placebo for 12 weeks, and researchers measure changes in PTSD severity using a standard clinical scale. The study also monitors for side effects like suicidal thoughts.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: fluoxetine (a common antidepressant)
What this could lead to: If successful, this could provide a reliable treatment option to reduce PTSD symptoms in military and civilian populations.
What could go wrong: This is an early phase 2 trial with 800 participants, so results may not confirm effectiveness. Fluoxetine is already used for depression, but its benefit for PTSD is not proven, and side effects like suicidal thoughts are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

post-traumatic stress disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POST-TRAUMATIC STRESS DISORDER

Contacts and locations

Locations

Advanced Discovery Research

Atlanta, Georgia, 30318, United States
Alexander T. Augusta Military Medical Center (ATAMMC):

Fort Belvoir, Virginia, 22060-5285, United States
Cincinnati Veteran's Affairs Medical Center

Fort Thomas, Kentucky, 41075, United States
Homestead Associates in Research, Inc.

Miami, Florida, 33032, United States
Madigan Army Medical Center

Joint Base Lewis McChord, Washington, 98433, United States
Tripler Army Medical Center (TAMC)

Tripler AMC, Hawaii, 96859, United States
Upstate Clinical Research Associates, LLC

Williamsville, New York, 14221, United States
Walter Reed National Military Medical Center (WRNMC)

Bethesda, Maryland, 20889-5632, United States
Wilford Hall Ambulatory Surgical Center (WHASC)

San Antonio, Texas, 78236, United States

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