Can a neck injection quiet the Brain's fear response in PTSD?
NCT ID NCT05391971
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether injecting an anesthetic near certain neck nerves (stellate ganglion block) can reduce PTSD symptoms by calming overactive stress responses. About 79 adults with chronic PTSD will receive either the anesthetic or a placebo (saline) injection. Researchers will measure changes in brain activity and skin sweat responses before and after the procedure.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
bupivacaine (anesthetic)
What this could lead to
If it works, this could offer a new, non-drug option to ease PTSD symptoms by temporarily calming the body's stress alarm system.
What could go wrong
This is a small, early-stage trial with only 79 participants, so results may not apply to everyone. The effect may be short-lived or no better than a placebo injection.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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NYU Langone Health
New York, New York, 10016, United States