Magic mushroom compound tested for OCD in small trial
NCT ID NCT05370911
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage study is testing whether repeated doses of psilocybin, the active ingredient in magic mushrooms, can reduce symptoms of obsessive-compulsive disorder (OCD). Twenty-eight adults with moderate-to-severe OCD who have not responded to standard treatments will receive two doses of psilocybin. The study uses a waitlist control group and measures changes in OCD severity using a standard rating scale.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- psilocybin (synthetic magic mushroom ingredient)
- What this could lead to
- If it works, this could point toward a new treatment option for people with obsessive-compulsive disorder who haven't found relief from standard therapies.
- What could go wrong
- This is a very early Phase 1 trial with only 28 participants, so results may not apply to everyone. Psilocybin can cause intense psychological effects and is not yet proven safe or effective for OCD.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Enact Research Collaborative (40 Temple St, 4th Floor)
New Haven, Connecticut, 06510, United States
-
Yale Program for Psychedelic Research
New Haven, Connecticut, 06510, United States
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