National University Hospital, Singapore

This study compares pulpotomy (removing only the infected part of the tooth's nerve) to root canal treatment for very deep cavities. About 93 people aged 12 and older with a single deeply decayed tooth will be randomly assigned to one of the two treatments. The main goal is to se…

This study tests if dupilumab can help children with severe nephrotic syndrome stay relapse-free longer. About 66 kids aged 6-18 will receive either dupilumab or a placebo injection every 2-4 weeks for 6 months, while slowly reducing their steroid dose. The goal is to see if dupi…

This study tests whether two HIV medications, emtricitabine and Descovy, are safe for people with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Researchers think these drugs might slow memory decline by blocking a process linked to Alzheimer's. Abo…

This study tests a lower dose of the targeted drug osimertinib in 58 adults with advanced EGFR-positive non-small cell lung cancer. The goal is to see if the lower dose is safer while still controlling the disease. Participants take the drug every other day, and researchers monit…

This study tests whether adding the antibiotic doxycycline to standard tuberculosis (TB) treatment can reduce lung damage and improve heart health. About 150 adults with active TB and lung cavities will receive either doxycycline or a placebo for 8 weeks. Researchers will measure…

This study tests whether adding two extra drugs (pembrolizumab and bevacizumab) to standard chemotherapy can improve outcomes for people with advanced nasopharyngeal cancer. About 50 adults with stage III or IVA disease will receive either standard chemo or the four-drug combo. T…

This study looks at whether taking myo-inositol, a natural supplement, during pregnancy can help women with type 2 diabetes have healthier babies. The goal is to see if it reduces risks like early delivery or low birth weight. About 182 pregnant women will take the supplement alo…

This study tests a new CAR T-cell therapy for people with B-cell lymphoma that has come back or not responded to other treatments. About 30 participants will receive specially engineered immune cells targeting CD19 and/or CD22 proteins on their cancer cells. The goal is to find t…

This study is testing whether a blood test can be used as a first step to see who really needs a low-dose CT scan for lung cancer. The goal is to avoid unnecessary scans, radiation, and costs for people at high risk, including smokers and those with a family history of lung cance…

This study tests a special sensor that listens to chest sounds to help doctors find pneumonia sooner in people who have had a stroke or are on dialysis. About 50 adults will take part. The sensor detects abnormal sounds that may mean pneumonia, which is then checked with a chest …

This study tests a special cooling sleeve worn on the arms and legs during chemotherapy to prevent nerve damage, a common side effect. About 80 cancer patients receiving weekly paclitaxel will try the device. Researchers will check for side effects and ask patients about numbness…

This small pilot study is testing whether adding a gentle electrical stimulation to the spinal cord (tSCS) can boost the benefits of robotic arm training for people with chronic tetraplegia (paralysis of arms and legs). Six to eight participants will first receive robotic trainin…

This study compares ready-to-eat very low calorie meals to standard liquid meal replacements for people preparing for bariatric surgery. The goal is to see if the ready-to-eat option improves how well patients stick to their diet, measured by blood ketones and meal logging. About…

This study tests whether a dental mouthpiece or a CPAP machine better improves memory and thinking in people with sleep apnea and mild cognitive issues. About 260 adults aged 45 and older will be randomly assigned to one of the two treatments for one year. The goal is to see whic…

This study tests if a non-invasive brain stimulation technique called TMS can reduce chronic tinnitus (ringing in the ears). 50 adults with tinnitus will receive 10 real TMS sessions and 10 sham (fake) sessions in random order, with a 2-week break in between. An MRI brain scan is…

This study tests whether early occupational therapy—including motivating activities and sleep-promoting routines—can reduce delirium (sudden confusion) in patients after coronary artery bypass surgery. About 300 adults will be randomly assigned to receive either the special thera…

This small pilot study tests whether adding transcutaneous spinal cord stimulation (tSCS) to robotic gait training helps improve trunk control and walking ability in people with chronic spinal cord injury. About 12 participants will first receive robotic training alone, then robo…

This early-phase study tests whether an artificial intelligence platform can personalize cancer treatment for people with solid tumors (like breast or gastrointestinal cancer). Researchers will use a patient's own tumor sample to pick the best drug combination, then an AI system …

This study involves 10 adults with recurrent high-grade astrocytic glioma, a type of brain cancer. Researchers will take a sample of the tumor, grow it in the lab, and test different drug combinations to see which works best. The goal is to see if this personalized approach can h…

This study aims to help older adults in Singapore stay healthy as they age. Researchers will screen 2,500 people aged 60 and older for early signs of decline in areas like memory, mobility, and mood. Those who need help will be offered community programs or doctor referrals. The …

This study looks at whether a special hospital unit called an Acute Medical Unit (AMU) can provide better care for older adults with sudden illnesses like infections, falls, or COPD flare-ups. Researchers will compare patients who go to the AMU with those who get usual hospital c…