National University Hospital, Singapore

This study compares two materials used to seal root canals after treatment. Researchers want to see if a newer bioceramic sealer (TotalFill) leads to better healing of the bone around the tooth root compared to a commonly used sealer (AH Plus). They will also track patients' pain…

This study is testing whether adding a drug called lenvatinib to standard hormone therapy (letrozole) can better shrink breast tumors before surgery. It involves post-menopausal women with newly diagnosed, hormone receptor-positive breast cancer. The research first aims to find a…

This study aims to understand how the brain changes after a stroke to predict how well a person's arm will recover. Researchers will use brain scans and tests to track recovery over a year. For some participants, they will also test if a mild, non-invasive brain stimulation treat…

This is the first study to test a new antibody drug called PRL3-ZUMAB in people. The goal is to find a safe dose for patients with advanced solid tumors or blood cancers that have stopped responding to standard treatments. Researchers will give increasing doses to small groups of…

This early-stage study is testing the safety and best dose of a new three-drug combination for people with advanced liver cancer (hepatocellular carcinoma) who haven't had other drug treatments. The combination adds a new experimental RNA drug (MTL-CEBPA) to two existing cancer d…

This small, early-stage study is testing whether adding a common antibiotic called ciprofloxacin to standard chemotherapy can help control advanced pancreatic cancer that has spread. It will involve 10 patients who are about to start their first chemotherapy treatment. The goal i…

This study is testing an oral drug called Lonsurf in people whose breast cancer has spread and worsened despite other treatments. It aims to see if the drug can slow or stop the cancer's growth for a meaningful period. The trial will enroll 86 participants, including those who ha…

This study is testing if the drug pacritinib can help control the growth of advanced solid tumors that have a specific genetic feature called 1q21.3 amplification. It is enrolling up to 74 adults with cancers, mostly breast cancer, that have stopped responding to standard treatme…

This study is testing a new AI tool that scans a patient's face to predict if placing a breathing tube will be difficult before surgery. It aims to help anesthesiologists identify high-risk patients in advance to improve safety. The system analyzes facial structure using a 3D sca…

This study is testing different outreach methods, like mailers and app notifications, to see which ones best encourage women in Singapore to schedule and attend their mammogram appointments. It focuses on two groups: women who have never had a mammogram and women who are overdue …

This study compares two numbing medicines (bupivacaine and prilocaine) given via spinal injection for knee replacement surgery. It aims to see if prilocaine allows patients to regain leg movement faster after surgery, which could help them start rehabilitation sooner and potentia…

This long-term study aims to understand how a mother's health, lifestyle, and environment during pregnancy, combined with a child's early life, influence the risk of developing future health problems like diabetes, obesity, and mental health conditions. Researchers are following …