Could surgery after chemo double survival for advanced stomach cancer?

NCT ID NCT07241715

Ongoing Disease control Sponsor: National University Hospital, Singapore Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether surgery to remove stomach cancer that has spread to the abdomen can help people live longer when done after chemotherapy. About 300 adults whose cancer responded well to initial treatment will be randomly assigned to either have surgery plus more therapy or continue therapy alone. The main goal is to see if surgery improves overall survival and quality of life.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Conversion surgery (surgery to remove the stomach tumor and cancer spread) plus systemic therapy (chemotherapy, targeted therapy, immunotherapy) with or without chemotherapy given directly into the abdomen
What this could lead to: If it works, this could show that surgery after chemotherapy helps people with advanced stomach cancer live longer and have a better quality of life.
What could go wrong: This is a mid-stage trial, so results are not yet proven. Surgery in this setting carries risks like infection or complications, and the cancer may still come back.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

gastric cancer gastric neoplasm peritoneal carcinomatosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

GASTRIC CANCER STAGE IV PERITONEAL METASTASIS

Contacts and locations

Locations

National University Hospital

Singapore, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.