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20-Year study to unlock secrets of pregnancy and child health

NCT ID NCT01174875

Knowledge-focused Sponsor: National University Hospital, Singapore Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows about 1,200 mothers from early pregnancy and their children for at least 20 years. Researchers want to learn how genetics, diet, lifestyle, and environment during pregnancy and early childhood affect the risk of metabolic and mental health conditions later in life. The goal is to understand these connections, not to test a treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

1,247 people

The number who actually took part.

Started

Jun 2009

Expected to finish

Jul 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Pregnant women attending their first-trimester antenatal visit at public maternity units in KKH and NUH, along with their children born from the indexed pregnancy.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria of Mother Participants: * Women 18 years and above * Pregnant women attending the first visit (\< 14 weeks GA) at the maternity units of KKH and NUH * Singapore citizens or Singapore Permanent Residents * Currently resident in mainland Singapore * Intention to eventually deliver in KKH or NUH * Intention to reside in Singapore for the next 5 years * Intention to donate cord, cord blood and placenta * The fetus should be racially homogenous with both sets of grandparents of the same ethnicity Exclusion Criteria of Mother Participants: * Women whose pregnancies end in miscarriages will be excluded * Pregnant women on chemotherapy * Exclude women with significant medical conditions e.g. Type 1 diabetes mellitus, psychosis etc. * Exclude women on certain medications - e.g. psychotropic drugs. * Mixed marriages will be excluded Babies born from these mothers will be invited to participate and followed up until the child is at least 20 years of age.

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Conditions

The condition(s) this trial relates to.

Developmental Origins of Health and Disease inherited disease susceptibility metabolic disease Neurologic Manifestations skin disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Environmental exposure Genetic predisposition Metabolic diseases Neurological and mental health conditions Psychology, social Skin condition Socioeconomic factors

Contacts and locations

Locations

  • National University Hospital

    Singapore, Singapore, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.