Idiopathic hypersomnia

This study looks at the long-term safety and tolerability of the drug TAK-360 in people with narcolepsy (type 1 or 2) or idiopathic hypersomnia — conditions that cause severe daytime sleepiness. Participants who completed a previous TAK-360 study can join and will continue taking…

This study is a long-term follow-up for people with narcolepsy or idiopathic hypersomnia who previously took the experimental drug ORX750. Researchers want to see if the drug remains safe and effective over time. About 90 participants will take ORX750 orally and be monitored for …

This study is testing whether simple wearable devices can accurately screen for sleep disorders in children with cerebral palsy. About 140 children aged 6 to 15 will wear the devices at home and then undergo a standard hospital sleep test. The goal is to see if the wearable metho…

This study tests an experimental drug called HBS-301 to see if it can reduce symptoms of idiopathic hypersomnia, a condition causing severe daytime sleepiness, trouble waking up, and fatigue. About 248 adults with moderate to very severe symptoms will receive either the drug or a…

This study tests a new drug called ALKS 2680 to see if it can safely reduce daytime sleepiness in people with idiopathic hypersomnia, a condition causing excessive sleepiness without clear cause. About 126 participants will receive either the drug or a placebo daily for 8 weeks. …

This study looks at how a low-sodium version of the drug oxybate affects total sleep time in adults with idiopathic hypersomnia, a condition causing excessive sleepiness. About 30 participants will use sleep trackers and special earbuds to measure sleep. The goal is to see if the…

This study tests a new drug called ORX750 (cleminorexton) in 248 adults with narcolepsy type 1, type 2, or idiopathic hypersomnia—conditions that cause severe daytime sleepiness. The drug mimics a natural brain protein that helps keep people awake. The main goals are to check saf…

This study follows 1,000 adults in Canada who are authorized to use medical cannabis for pain, sleep issues, anxiety, depression, or epilepsy. Researchers will track changes in symptoms using standard questionnaires over 24 weeks. The goal is to see how well medical cannabis work…

This Phase 2 trial tests TAK-360, a drug that mimics the brain chemical orexin, in 96 adults with idiopathic hypersomnia (IH). IH causes severe daytime sleepiness and trouble waking up, even after long sleep. Participants will receive either TAK-360 or a placebo to see if the dru…

This study is testing the long-term safety and how well ALKS 2680 works over time in people with narcolepsy type 1, type 2, or idiopathic hypersomnia. Participants take a once-daily tablet at different doses. The goal is to see if the drug remains safe and effective for staying a…

This study tests a 4-week online course designed to help adults who experience parasomnias—unwanted sleep events like sleep terrors, sleepwalking, and nightmares. The course teaches safety planning, relaxation, and therapy techniques. Researchers will measure whether it reduces h…

This study tests whether a special memory support program can help people aged 50 and older remember and stick to their sleep treatment. The program uses simple memory strategies alongside standard sleep therapy. Researchers will track sleep quality, daily functioning, and life s…

This study tests whether taking branched chain amino acids (BCAAs) twice a day for three weeks can improve sleep in people with traumatic brain injury. Researchers will also check if the supplement is easy to take and if participants stick with it. The study involves 300 veterans…

This study looks at whether taking a nap during a night shift can improve blood pressure and alertness in healthcare and public safety workers. Researchers will compare naps lasting 0, 15, 30, 45, or 60 minutes taken at 2:00 AM. The goal is to find the nap length that best balanc…

This study looks at how eating affects sleepiness and nighttime sleep in people with type 1 narcolepsy, idiopathic hypersomnia, and healthy volunteers. Over 4 days, participants will log their meals, wear a glucose monitor, and track sleep with a headband and watch. The goal is t…

This study looks at how narcolepsy (types 1 and 2) and idiopathic hypersomnia affect social cognition—skills like recognizing emotions and making decisions. Researchers will give 75 adults several questionnaires to measure attention, impulse control, empathy, and emotion recognit…

This study looks at sleep inertia—the grogginess and poor attention right after waking—in people with major depression. Researchers will test reaction times and monitor sleep in 110 participants, including depressed patients with and without sleep inertia, plus healthy controls. …