New pill aims to fight excessive daytime sleepiness

NCT ID NCT06843590

Recruiting now Symptom relief Sponsor: Alkermes, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called ALKS 2680 to see if it can safely reduce daytime sleepiness in people with idiopathic hypersomnia, a condition causing excessive sleepiness without clear cause. About 126 participants will receive either the drug or a placebo daily for 8 weeks. Researchers will measure changes in sleepiness using standard questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALKS 2680
What this could lead to: If it works, this could lead to a new treatment option to reduce excessive daytime sleepiness in people with idiopathic hypersomnia.
What could go wrong: This is an early Phase 2 trial with only 126 participants, so results may not confirm effectiveness or safety. The drug may cause side effects or fail to improve sleepiness compared to placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Disorders of Excessive Somnolence idiopathic hypersomnia sleep-wake disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC HYPERSOMNIA

Contacts and locations

Locations

Alkermes Investigational Site
RECRUITING

Boulder, Colorado, 80301, United States
Alkermes Investigational Site
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Boston, Massachusetts, 02215, United States
Alkermes Investigator Site
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Cullman, Alabama, 35055, United States
Alkermes Investigator Site
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Phoenix, Arizona, 85054, United States
Alkermes Investigator Site
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Little Rock, Arkansas, 72211, United States
Alkermes Investigator Site
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Los Angeles, California, 90025, United States
Alkermes Investigator Site
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Redwood City, California, 94063, United States
Alkermes Investigator Site
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San Francisco, California, 94143, United States
Alkermes Investigator Site
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Colorado Springs, Colorado, 80918, United States
Alkermes Investigator Site
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Brandon, Florida, 33511, United States
Alkermes Investigator Site
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Miami, Florida, 33176, United States
Alkermes Investigator Site
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Winter Park, Florida, 32789, United States
Alkermes Investigator Site
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Atlanta, Georgia, 30328, United States
Alkermes Investigator Site
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Macon, Georgia, 31210, United States
Alkermes Investigator Site
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Stockbridge, Georgia, 30281, United States
Alkermes Investigator Site
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Peoria, Illinois, 61637, United States
Alkermes Investigator Site
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Kansas City, Kansas, 66160, United States
Alkermes Investigator Site
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Lansing, Michigan, 48911, United States
Alkermes Investigator Site
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Lincoln, Nebraska, 68506, United States
Alkermes Investigator Site
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Middletown, New Jersey, 07748, United States
Alkermes Investigator Site
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Denver, North Carolina, 28037, United States
Alkermes Investigator Site
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Huntersville, North Carolina, 28078, United States
Alkermes Investigator Site
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Canton, Ohio, 44718, United States
Alkermes Investigator Site
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Cincinnati, Ohio, 45245, United States
Alkermes Investigator Site
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Cleveland, Ohio, 44195, United States
Alkermes Investigator Site
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Danville, Pennsylvania, 17822, United States
Alkermes Investigator Site
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Philadelphia, Pennsylvania, 19107, United States
Alkermes Investigator Site
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Wyomissing, Pennsylvania, 19610, United States
Alkermes Investigator Site
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Columbia, South Carolina, 29201, United States
Alkermes Investigator Site
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Austin, Texas, 78731, United States
Alkermes Investigator Site
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San Antonio, Texas, 78229, United States
Alkermes Investigator Site
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Sugar Land, Texas, 77478, United States
Alkermes Investigator Site
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Sugarland, Texas, 77478, United States
Alkermes Investigator Site
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Madison, Wisconsin, 53792, United States
Alkermes Investigator Site
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Sydney, New South Wales, 2113, Australia
Alkermes Investigator Site
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Bedford Park, South Australia, 5042, Australia
Alkermes Investigator Site
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Clayton, Victoria, 3168, Australia
Alkermes Investigator Site
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Alken, 3570, Belgium
Alkermes Investigator Site
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Namur, 5101, Belgium
Alkermes Investigator Site
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Prague, 128 21, Czechia
Alkermes Investigator Site
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Bordeaux, Gironde, 33000, France
Alkermes Investigator Site
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Montpellier, Herault, 34295, France
Alkermes Investigator Site
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Grenoble, Isere, 38043, France
Alkermes Investigator Site
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Bologna, 40139, Italy
Alkermes Investigator Site
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Milan, 20127, Italy
Alkermes Investigator Site
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Verona, 37134, Italy
Alkermes Investigator Site
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Zwolle, 8025 BV, Netherlands
Alkermes Investigator Site
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Barcelona, 8036, Spain
Alkermes Investigator Site
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Madrid, 28036, Spain
Alkermes Investigator Site
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Madrid, 28043, Spain

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