Can depression explain extreme daytime sleepiness? a sleep study investigates

NCT ID NCT05850676

Recruiting now Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jul 22, 2026 · Last updated Jul 23, 2026 · Updated 1 time

Summary

This study looks at the link between depression and hypersomnia—a condition causing excessive sleepiness. Researchers will monitor brain activity during sleep and measure reward function in 45 adults with idiopathic hypersomnia or hypersomnia linked to a psychiatric disorder. The goal is to understand whether mood-related changes in deep sleep contribute to excessive daytime sleepiness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

What this could lead to: If successful, this research could clarify whether depression drives hypersomnia or vice versa, potentially pointing toward more targeted treatments.
What could go wrong: This is a small observational study, not a treatment trial. It may not produce clear answers, and results may not apply to all people with hypersomnia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Disorders of Excessive Somnolence hypersomnia idiopathic hypersomnia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HYPERSOMNIA

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

The University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19104, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

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