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Can depression explain extreme daytime sleepiness? a sleep study investigates

NCT ID NCT05850676

Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 22, 2026 · Last updated Aug 07, 2026 · Updated 3 times

Summary

This study looks at the link between depression and hypersomnia—a condition causing excessive sleepiness. Researchers will monitor brain activity during sleep and measure reward function in 45 adults with idiopathic hypersomnia or hypersomnia linked to a psychiatric disorder. The goal is to understand whether mood-related changes in deep sleep contribute to excessive daytime sleepiness.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could clarify whether depression drives hypersomnia or vice versa, potentially pointing toward more targeted treatments.
What could go wrong
This is a small observational study, not a treatment trial. It may not produce clear answers, and results may not apply to all people with hypersomnia.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

54 people

The number who actually took part.

Started

Aug 2023

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adults with Idiopathic Hypersomnia or Hypersomnia Associated with a Psychiatry Disorder

Ages

21 to 55 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Males and females between the age of 21 and 55 * Meet DSM5 criteria for Idiopathic Hypersomnia or Hypersomnia Associated with a Psychiatry Disorder * Ability to read and speak English Exclusion Criteria: * Unable or unwilling to provide informed consent * Untreated obstructive sleep apnea (apnea-hypopnea index /= 15 events/hr) * Meeting diagnostic criteria for narcolepsy * A clinically unstable medical condition as defined by a new diagnosis or change in medical management in the previous 2 months (e.g., pneumonia, thyroid disease, ventricular arrhythmias, cirrhosis, surgery, or recently diagnosed cancer) because these changes could impact daytime hypersomnia and confound results * Substance abuse/dependence, delirium, dementia, amnestic disorder, schizophrenia, and other psychotic disorders * Prominent current suicidal or homicidal ideation. * Unable to perform tests due to inability to communicate verbally, inability to read and write; less than a 5th grade reading level; visal, hearing, or cognitive impairment (e.g. previous head injury) * Use of medications or OTC products that might impact sleep

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Conditions

The condition(s) this trial relates to.

Disorders of Excessive Somnolence hypersomnia idiopathic hypersomnia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypersomnia

Contacts and locations

Locations

  • The University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

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