Idiopathic hypersomnia

This trial tests whether a low-sodium form of oxybate, called XYWAV, can reduce daytime sleepiness and improve daily function in adults aged 18 to 75 with idiopathic hypersomnia or narcolepsy. Participants take the oral solution at night, with doses adjusted to their needs, and r…

This study tests whether clarithromycin, an antibiotic, can reduce excessive daytime sleepiness in people with narcolepsy or idiopathic hypersomnia. Participants receive either clarithromycin or a placebo for 14 days. Researchers will measure changes in sleepiness, brain activity…

This study looks at the long-term safety and effectiveness of pitolisant in adults with idiopathic hypersomnia, a condition causing excessive daytime sleepiness. Participants had already completed a previous study. The goal is to see if pitolisant remains safe and helps control s…

This study explores whether a three-dimensional electronic pulse diagnostic device can accurately identify Traditional Chinese Medicine (TCM) syndromes in people with sleep disorders. Participants undergo pulse measurements and symptom assessments, and the device's results are co…

This study compares a new mass spectrometry technique to the standard radioimmunoassay for measuring orexin-A levels in cerebrospinal fluid. Orexin-A is a key brain chemical that is low in people with type 1 narcolepsy. The study involves 117 people with excessive daytime sleepin…

This study tested a headband called Dreem 3S that people wear at home to monitor sleep and wake patterns. The goal was to see if it can help diagnose narcolepsy, a condition that causes extreme daytime sleepiness. 78 adults took part, and researchers checked how well the device w…

This trial tests whether a nurse-led program of sleep hygiene education and progressive muscle relaxation can improve sleep quality in obese pregnant women. Researchers will enroll 100 women in their third trimester with a BMI of 30 or higher and sleep problems. Half will receive…

This trial tests whether a daily sleep gummy can improve sleep quality and quantity in adults aged 20-50 who have self-reported sleep issues. Participants take one gummy before bed for 7 days while wearing a Fitbit tracker to measure sleep patterns. The study compares sleep metri…

This trial tests whether different combinations of cannabinoids—THC, CBN, CBG, CBD, and melatonin—taken as gummies can improve sleep quality in adults aged 21 to 55 who report poor sleep. Participants will be randomly assigned to receive one of several active gummy formulas or a …

This trial tests whether a set of EMF protection devices—including pads, chips, and bands—can improve sleep quality and energy levels in adults aged 30-60 who have trouble sleeping. Participants use all devices daily for about four weeks while tracking sleep with a wearable ring …

This study tests whether personalized advice on sleep timing, light exposure, meal times, and physical activity can improve sleep quality in adults aged 65 and older who have poor sleep. Participants are randomly assigned to receive either general sleep advice or a customized pla…

This study tests an oral drug called SDX (serdexmethylphenidate) to see if it safely reduces excessive daytime sleepiness in adults with idiopathic hypersomnia, a condition where people feel extremely sleepy during the day despite getting enough sleep at night. Participants will …

This study tested a once-nightly extended-release form of sodium oxybate (FT218) in 157 adults with idiopathic hypersomnia, a condition causing excessive daytime sleepiness despite adequate sleep. Participants were already on stable doses of stimulants or other alerting agents. T…

This study tested a dietary supplement called Speed Sleep in 60 adults aged 18-65 who have trouble sleeping. Participants took either the supplement or a placebo daily for 4 weeks. Sleep quality and quantity were measured using Fitbit trackers and questionnaires.

This study tested whether a daily mix of plant protein and two herbs (ashwagandha and rhodiola) could improve sleep in 100 adults aged 35-70 with sleep troubles. Participants took either the supplement or a placebo for 30 days and reported their sleep quality daily. The goal was …

This early study tested a product called Chenghuang Circadian Rhythm Regulator in 15 adults with ongoing sleep problems. The goal was to see if it could improve sleep quality and immune markers. Results are not yet reported, but the study was small and had no comparison group.

This study tested whether a headband called Muse-S, which senses brain activity, could help midlife women with sleep problems like insomnia. Thirty-one women going through menopause wore the device at home. The goal was to see if it was practical and if it improved sleep quality …

This study tested whether acupressure—a gentle finger-pressure technique on specific body points—could improve sleep in elderly people living in care homes. 75 residents took part, with half receiving 12 acupressure sessions over four weeks. The results showed that those who rece…

This study tested an online program called ALDER that teaches older adults skills to boost positive emotions and reduce anxiety. 33 people aged 65 and older who used benzodiazepines (anti-anxiety or sleep medications) at least twice a week took part. Over 5 weeks, they learned an…

This study tested a sleep and circadian treatment (TranS-C) for people with severe mental illness (SMI) in community mental health centers. The treatment was adapted to better fit these settings. Researchers looked at whether it improved sleep, daily functioning, and symptoms in …

This study tested two versions of a sleep treatment for people with severe mental illness in community mental health centers. One version was the standard treatment, and the other was adapted to better fit patients' needs. The goal was to see if training clinic staff to deliver t…

This study looks at the link between depression and hypersomnia—a condition causing excessive sleepiness. Researchers will monitor brain activity during sleep and measure reward function in 45 adults with idiopathic hypersomnia or hypersomnia linked to a psychiatric disorder. The…

This study tested a computer system designed to help doctors more accurately diagnose and manage complex brain disorders like dementia, epilepsy, and sleep problems. Researchers collected health data from 635 people visiting specialty clinics, including healthy volunteers, to see…

This study tested a website designed to help teenagers with narcolepsy or idiopathic hypersomnia and their families understand and improve social relationships. Twenty-five teens and their parents reviewed the website's content, which included animations, patient stories, and exp…

This study looked at whether a 25-minute or 45-minute nap helps teenage soccer players run faster and feel less tired. Sixteen male players tried both nap lengths and a no-nap day. Results showed that napping improved agility and made exercise feel easier, but did not help them k…