New pill shows promise for keeping people with narcolepsy awake longer

NCT ID NCT06767683

Recruiting now Symptom relief Sponsor: Alkermes, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Aug 07, 2026 · Updated 2 times

Summary

This study is testing the long-term safety and how well ALKS 2680 works over time in people with narcolepsy type 1, type 2, or idiopathic hypersomnia. Participants take a once-daily tablet at different doses. The goal is to see if the drug remains safe and effective for staying awake during the day.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ALKS 2680 (a once-daily tablet)
What this could lead to: If successful, this could provide a long-term treatment option to help people with narcolepsy or idiopathic hypersomnia stay awake during the day.
What could go wrong: This is an extension study, so participants have already completed an earlier trial. It is still testing safety and durability, and side effects or lack of lasting benefit are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Disorders of Excessive Somnolence idiopathic hypersomnia narcolepsy narcolepsy without cataplexy narcolepsy-cataplexy syndrome sleep-wake disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC HYPERSOMNIA NARCOLEPSY TYPE 1 NARCOLEPSY TYPE 2

Contacts and locations

Locations

Alkermes Investigational Site
RECRUITING

Cullman, Alabama, 35055, United States
Alkermes Investigational Site
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Little Rock, Arkansas, 72211, United States
Alkermes Investigational Site
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Los Angeles, California, 90025, United States
Alkermes Investigational Site
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Stanford, California, 94305, United States
Alkermes Investigational Site
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Boulder, Colorado, 80309, United States
Alkermes Investigational Site
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Colorado Springs, Colorado, 80918, United States
Alkermes Investigational Site
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Brandon, Florida, 33511, United States
Alkermes Investigational Site
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Miami, Florida, 33176, United States
Alkermes Investigational Site
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Winter Park, Florida, 32789, United States
Alkermes Investigational Site
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Atlanta, Georgia, 30328, United States
Alkermes Investigational Site
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Macon, Georgia, 31210, United States
Alkermes Investigational Site
RECRUITING

Stockbridge, Georgia, 30281, United States
Alkermes Investigational Site
RECRUITING

Peoria, Illinois, 61637, United States
Alkermes Investigational Site
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Kansas City, Kansas, 66160, United States
Alkermes Investigational Site
RECRUITING

Lansing, Michigan, 48911, United States
Alkermes Investigational Site
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Sterling Heights, Michigan, 48314, United States
Alkermes Investigational Site
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Lincoln, Nebraska, 68506, United States
Alkermes Investigational Site
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Middletown, New Jersey, 07748, United States
Alkermes Investigational Site
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Denver, North Carolina, 28037, United States
Alkermes Investigational Site
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Huntersville, North Carolina, 28708, United States
Alkermes Investigational Site
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Canton, Ohio, 44718, United States
Alkermes Investigational Site
RECRUITING

Cincinnati, Ohio, 45212, United States
Alkermes Investigational Site
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Cincinnati, Ohio, 45245, United States
Alkermes Investigational Site
RECRUITING

Dublin, Ohio, 43017, United States
Alkermes Investigational Site
RECRUITING

Abington, Pennsylvania, 19001, United States
Alkermes Investigational Site
RECRUITING

Wyomissing, Pennsylvania, 19610, United States
Alkermes Investigational Site
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Columbia, South Carolina, 29201, United States
Alkermes Investigational Site
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Austin, Texas, 78731, United States
Alkermes Investigational Site
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San Antonio, Texas, 78229, United States
Alkermes Investigational Site
RECRUITING

Sugar Land, Texas, 77478, United States
Alkermes Investigational Site
RECRUITING

Madison, Wisconsin, 53706, United States
Alkermes Investigational Site
RECRUITING

Sydney, New South Wales, 2113, Australia
Alkermes Investigational Site
RECRUITING

Bedford Park, South Australia, 5042, Australia
Alkermes Investigational Site
RECRUITING

Clayton, Victoria, 3168, Australia
Alkermes Investigational Site
RECRUITING

Bruges, Brugge, 8000, Belgium
Alkermes Investigational Site
RECRUITING

Alken, 3570, Belgium
Alkermes Investigational Site
RECRUITING

Namur, 5101, Belgium
Alkermes Investigational Site
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Prague, 128 21, Czechia
Alkermes Investigational Site
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Montpellier, Herault, 34295, France
Alkermes Investigational Site
RECRUITING

Bordeaux, 33000, France
Alkermes Investigational Site
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Bologna, 40139, Italy
Alkermes Investigational Site
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Milan, 20127, Italy
Alkermes Investigational Site
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Verona, 37134, Italy
Alkermes Investigational Site
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Zwolle, 8025, Netherlands
Alkermes Investigational Site
RECRUITING

Madrid, Madrid, 28036, Spain
Alkermes Investigational Site
RECRUITING

Barcelona, 08036, Spain
Alkermes Investigational Site
RECRUITING

Madrid, 28043, Spain
Alkermes Investigator Site
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Phoenix, Arizona, 85054, United States
Alkermes Investigator Site
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San Francisco, California, 94158, United States

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