New sleepiness drug could change lives for narcolepsy and hypersomnia patients

NCT ID NCT06752668

Recruiting now Symptom relief Sponsor: Centessa Pharmaceuticals (UK) Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new drug called ORX750 (cleminorexton) in 248 adults with narcolepsy type 1, type 2, or idiopathic hypersomnia—conditions that cause severe daytime sleepiness. The drug mimics a natural brain protein that helps keep people awake. The main goals are to check safety and see if it reduces sleepiness and improves daily function.

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Conditions

The condition(s) this trial relates to.

idiopathic hypersomnia narcolepsy without cataplexy narcolepsy-cataplexy syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

IDIOPATHIC HYPERSOMNIA NARCOLEPSY TYPE 1 NARCOLEPSY TYPE 2

Contacts and locations

Locations

Atlanta, Georgia
RECRUITING

Atlanta, Georgia, 30281, United States
Atlanta, Georgia
RECRUITING

Atlanta, Georgia, 30328, United States
Auburn, Alabama
RECRUITING

Auburn, Alabama, 36832, United States
Austin, Texas
RECRUITING

Austin, Texas, 78731, United States
Bologna, Italy
RECRUITING

Bologna, 40139, Italy
Brandon, Florida
RECRUITING

Brandon, Florida, 33511, United States
Chandler, Arizona
RECRUITING

Chandler, Arizona, 85224, United States
Cincinnati, Ohio
RECRUITING

Cincinnati, Ohio, 45245, United States
Cleveland, OH
RECRUITING

Cleveland, Ohio, 44106, United States
Columbia, South Carolina
RECRUITING

Columbia, South Carolina, 29201, United States
Denver, North Carolina
RECRUITING

Denver, North Carolina, 28037, United States
Dublin, Ohio
RECRUITING

Dublin, Ohio, 43017, United States
El Paso, TX
RECRUITING

El Paso, Texas, 79912, United States
Henderson, Nevada
RECRUITING

Henderson, Nevada, 89052, United States
Huntersville, North Carolina
RECRUITING

Huntersville, North Carolina, 28078, United States
Leon, France
RECRUITING

Léon, Bordeaux, 33000, France
Long Beach, California
RECRUITING

Long Beach, California, 90805, United States
Madrid, Spain
RECRUITING

Madrid, 28036, Spain
Madrid, Spain
RECRUITING

Madrid, 28043, Spain
Miami, Florida
RECRUITING

Miami, Florida, 33155, United States
Miami, Florida
RECRUITING

Miami, Florida, 33176, United States
New Orleans, Louisiana
RECRUITING

New Orleans, Louisiana, 70127, United States
Newton, Massachusetts
RECRUITING

Newton, Massachusetts, 02459, United States
North Charleston, South Carolina
RECRUITING

North Charleston, South Carolina, 29406, United States
Orlando, FL
RECRUITING

Orlando, Florida, 32807, United States
Pozzilli, Italy
RECRUITING

Pozzilli, 86077, Italy
Riverdale, Georgia
RECRUITING

Riverdale, Georgia, 30274, United States
San Antonio, Texas
RECRUITING

San Antonio, Texas, 78229, United States
Santa Ana, California
RECRUITING

Santa Ana, California, 92705, United States
Scottsdale, Arizona
RECRUITING

Scottsdale, Arizona, 85253, United States
Southfield, Michigan
RECRUITING

Southfield, Michigan, 48075, United States
Sterling Heights, Michigan
RECRUITING

Sterling Heights, Michigan, 48314, United States
Toronto, Ontario
RECRUITING

Toronto, Ontario, M5S 3A3, Canada
Verona, Italy
RECRUITING

Verona, 37134, Italy
Vitoria-Gasteiz, Spain
RECRUITING

Vitoria-Gasteiz, 01009, Spain
Willow Grove, Pennsylvania
RECRUITING

Willow Grove, Pennsylvania, 19090, United States
Winter Park, Florida
RECRUITING

Winter Park, Florida, 32789, United States

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