Centessa Pharmaceuticals (uk) Limited

This study is a long-term follow-up for people with narcolepsy or idiopathic hypersomnia who previously took the experimental drug ORX750. Researchers want to see if the drug remains safe and effective over time. About 90 participants will take ORX750 orally and be monitored for …

This study tests an experimental drug called cleminorexton in 222 adults with narcolepsy type 1 or 2. The drug mimics a natural brain protein that helps keep people awake. The goal is to see if it safely reduces daytime sleepiness and improves daily functioning. Participants must…

This study tests a new drug called ORX750 (cleminorexton) in 248 adults with narcolepsy type 1, type 2, or idiopathic hypersomnia—conditions that cause severe daytime sleepiness. The drug mimics a natural brain protein that helps keep people awake. The main goals are to check saf…

This early-stage trial is testing a new drug called ORX142 in healthy adults and older adults to see if it is safe and how the body processes it. The study also looks at how food affects the drug and whether it can improve alertness in people who are sleep-deprived. About 208 par…

This early-stage study is testing a new drug called ORX489 in 212 healthy adults to see if it is safe and how the body handles it. Participants will receive single or multiple doses, and some will take it with or without food or after sleep deprivation. The goal is to gather safe…