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New narcolepsy pill mimics Brain's Wake-Up signal in major trial

NCT ID NCT07598708

Recruiting now Symptom relief Sponsor: Centessa Pharmaceuticals (UK) Limited Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 14, 2026 · Updated 4 times

Summary

This study tests an experimental drug called cleminorexton in 222 adults with narcolepsy type 1 or 2. The drug mimics a natural brain protein that helps keep people awake. The goal is to see if it safely reduces daytime sleepiness and improves daily functioning. Participants must stop their current narcolepsy medications during the trial.

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Conditions

The condition(s) this trial relates to.

Cataplexy Disorders of Excessive Somnolence Dyssomnias narcolepsy narcolepsy without cataplexy narcolepsy-cataplexy syndrome nervous system disorder psychiatric disorder sleep-wake disorder Sleepiness

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NARCOLEPSY TYPE 1 NARCOLEPSY TYPE 2

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Cincinnati, Ohio

    RECRUITING

    Cincinnati, Ohio, 45245, United States

  • Columbia, South Carolina

    RECRUITING

    Columbia, South Carolina, 29201, United States

  • Denver, North Carolina

    RECRUITING

    Denver, North Carolina, 28037, United States

  • Huntersville, North Carolina

    RECRUITING

    Huntersville, North Carolina, 28078, United States

  • Miami Lakes, Florida

    RECRUITING

    Miami Lakes, Florida, 33014, United States

  • Miami, Florida

    RECRUITING

    Miami, Florida, 33176, United States

  • Sugar Land, Texas

    RECRUITING

    Sugar Land, Texas, 77478, United States

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