Centessa Pharmaceuticals (uk) Limited

This study tests a new drug called ORX750 (cleminorexton) that mimics a natural brain protein (orexin) to help people stay awake. It includes 248 adults with narcolepsy type 1, type 2, or idiopathic hypersomnia. The main goals are to check safety and see if the drug reduces dayti…

This study looks at the long-term safety and effectiveness of a drug called ORX750 in people with narcolepsy (types 1 and 2) or idiopathic hypersomnia who have already completed a previous ORX750 study. About 90 participants will take the drug and be monitored for side effects an…

This early-stage study tests an experimental drug called ORX142 in healthy adults and older adults to see if it is safe and how the body handles it. The study also looks at how the drug affects people who are kept awake overnight. The goal is to find a new treatment for excessive…

This study is an early test of a new drug called ORX489 in 212 healthy adults. The main goal is to check if the drug is safe and how the body handles it. Participants will take single or multiple doses, and some will take it with or without food or after being sleep-deprived. Thi…