Can a weekly shot ease sleep apnea without a CPAP machine?
NCT ID NCT07767942
First seen Aug 17, 2026 · Last updated Aug 17, 2026
Summary
This phase 3 trial is testing whether an investigational drug called UBT251 can reduce the severity of obstructive sleep apnea in people who are obese and do not use positive airway pressure (PAP) therapy. Participants will receive weekly injections of UBT251 or a placebo for 52 weeks. The main goal is to see if UBT251 lowers the Apnea-Hypopnea Index (AHI), a measure of breathing pauses during sleep. The study also tracks safety and changes in body weight.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- UBT251, an investigational drug given as a weekly injection
- What this could lead to
- If effective, UBT251 could offer a drug-based alternative to CPAP for obese individuals with moderate-to-severe sleep apnea, potentially improving breathing during sleep and reducing related health risks.
- What could go wrong
- This is a phase 3 trial, but results are not yet known. The drug may not significantly reduce apnea events, and side effects from the injection or the drug itself are possible. Success in this trial does not guarantee approval or effectiveness for everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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