Melatonin timing matters: study tests if earlier is better for sleep

NCT ID NCT07514507

Not yet recruiting Knowledge-focused Sponsor: IRCCS Fondazione Stella Maris Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at whether taking melatonin earlier in the evening (3 hours before bed) or at a higher dose (4 mg) helps healthy adults fall asleep faster and sleep better. Fourteen participants will try different combinations of melatonin and placebo while their sleep is measured with brain wave monitoring. The goal is to find the most effective timing and dose for improving sleep.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Melatonin
What this could lead to: If it works, this could point toward better timing and dosing recommendations for melatonin to improve sleep in healthy people.
What could go wrong: This is a very small, early-stage study in healthy adults without sleep problems, so results may not apply to people with sleep disorders. The effects may be subtle or not meaningful in real life.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SLEEP DISORDERS are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

sleep-wake disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SLEEP DISORDERS

Contacts and locations

Locations

University of Pisa, Institute of Physiology, Sonnolab

Pisa, PI, 56126, Italy

More trials for these conditions

Other studies related to the condition(s) this trial covers.