Could a common drug stop teeth grinding and protect your heart?
NCT ID NCT03083405
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study examines the links between sleep bruxism (teeth grinding during sleep) and sleep quality, heart health, thyroid function, and mood. Researchers will give some participants opipramol, a drug that may reduce grinding activity, and monitor them with sleep tests. The goal is to better understand bruxism and explore a potential treatment. 100 adults with diagnosed sleep bruxism are being enrolled.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Opipramol
- What this could lead to
- If successful, this could point toward a treatment for sleep bruxism that also improves sleep and reduces related health risks.
- What could go wrong
- This is an early-stage study with only 100 participants, so results may not apply to everyone. Opipramol may cause side effects or not reduce bruxism effectively.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Wroclaw Medical University
Wroclaw, Poland
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