Could a pill calm brain inflammation in sleep disorder patients?
NCT ID NCT05904717
First seen Jun 07, 2026 · Last updated Jun 16, 2026 · Updated 4 times
Summary
This study tests an oral drug called PXS-4728A in 40 adults aged 50-80 with isolated REM sleep behavior disorder (iRBD), a condition where people act out their dreams. The goal is to see if the drug can reduce brain inflammation (measured by PET scans) and is safe. iRBD often leads to Parkinson's disease, so this research aims to slow or prevent that progression.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Clinical Neuroscience Nuffield Department of Clinical Neurosciences
Oxford, United Kingdom
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Cognitive Neuroscience Brain & Mind Centre
Camperdown, Sydney, 2050, Australia
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Parkinsons Disease Research Clinic - Macquarie University
Macquarie, New South Wales, 2109, Australia
Conditions
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Conditions inferred from the trial description
These were inferred from the trial's summary, not listed by the trial registrant.