Can a pill stop sleep disorder from turning into Parkinson's?

NCT ID NCT04534023

First seen Jun 27, 2026 ยท Last updated Jun 27, 2026

Summary

This study tests whether the drug idebenone can slow or prevent the progression of a sleep disorder called iRBD into Parkinson's disease or similar brain conditions. About 142 adults aged 40-75 with iRBD will receive either idebenone or a placebo for 5 years. Researchers will track how many people develop Parkinson's or related diseases using questionnaires, blood tests, and brain scans.

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Conditions

The condition(s) this trial relates to.

rapid eye movement sleep disorder REM sleep behavior disorder synucleinopathy prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Department of neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

    Shanghai, Shanghai Municipality, 200025, China